grant
Interactions between Trichuris and the gut microbiota
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Nov 2023Deadline 31 Oct 2028
NIHUS FederalResearch GrantFY202621+ years oldAdultAdult HumanAffectAlimentary CanalAnabolismAnemiaArginineAssayBackBacteriaBacterial Gene ProductsBacterial Gene ProteinsBacterial ProteinsBindingBioassayBiological AssayBloody diarrheaC elegansC. elegansC.elegansCaenorhabditis elegansChitinaseCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalColonCommunitiesDepositDepositionDevelopmentDietDigestive TractDiseaseDisorderDistantDisturbance in cognitionDorsumDrug resistanceDrugsE coliE. coliEnvironmentEscherichia coliFecesFeedsFrequenciesGI TractGI microbiotaGastrointestinal TractGastrointestinal microbiotaGastrointestinal tract structureGnotobioticGnotobioticsHelminthsHemorrhagic colitisHemorrhagic diarrheaHumanImpaired cognitionIn VitroIndividual DifferencesInfectionInflammatory ResponseIngestionIntestinalIntestinesKnock-outKnockoutKnowledgeL-ArginineLarge IntestineLarvaLibrariesLife CycleLife Cycle StagesLinkMalnutritionMammaliaMammalsMediatingMedicationMiceMice MammalsMicrobeModelingModern ManMolecular InteractionMurineMusNematodaNematodesNutritional DeficiencyOutcomeParasitesParasitic WormsParasitic nematodePathway interactionsPersonsPharmaceutical PreparationsPolyamine CompoundPolyaminesProductionReproductionRoleSeverity of illnessSignal InductionSiteSymptomsSystemT trichiuraT trichiura infectionT. trichiuraT. trichiura infectionTechniquesTestingTimeTrichocephaliasisTrichocephalusTrichocephalus trichiuraTrichuriasesTrichuriasisTrichurisTrichuris trichiuraTrichuris trichiura infectionUndernutritionadulthoodalimentary tractbacteria in the gutbacterial communitybiosynthesisbowelcognitive dysfunctioncognitive lossdevelopmentaldietary deficiencydietsdigestive canaldisease severitydrug resistantdrug/agenteggenteric microbial communityenteric microbiotagastrointestinal microbial floragut bacteriagut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiotagut microbioticgut microflorahatchinghost colonizationhuman florahuman microbial communitieshuman microbiotahuman microflorahuman pathogenhuman-associated microbial communitieshuman-associated microbiotaimprovedin vivoingestinnovateinnovationinnovativeintestinal floraintestinal microbiotaintestinal microfloraintestinal tract microfloralarge bowellife coursemalnourishedmicrobialmicrobial based biotherapeuticmicrobial based therapeuticmicrobial based therapymicrobial based treatmentmicrobiota compositionmouse modelmurine modelmutantnovelnutrition deficiencynutrition deficiency disordernutritional deficiency disorderparasitic roundwormpathwayreproductivereproductive fitnessresistance to Drugresistant to Drugroundwormsocial rolestooltherapeutic target
Description preview
PROJECT SUMMARY
Parasitic nematodes colonize over a billion people worldwide and are associated with a range of maladies.
Among these parasites, the whipworm Trichuris trichiura is particularly difficult to manage with existing
medication that target adult worms due to drug resistance and frequency of reinfection. Following ingestion by
the host,…
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