grant
Inter-organellar communication in metabolic reprogramming of colorectal cancer
Organization ROCKEFELLER UNIVERSITYLocation NEW YORK, UNITED STATESPosted 1 Mar 2025Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY2026AnabolismAutomobile DrivingAutoregulationBioenergeticsCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas9 screenCancer CauseCancer EtiologyCancersCell BodyCell DifferentiationCell Differentiation processCell SurvivalCell ViabilityCellsCessation of lifeCoenzyme QCoenzyme Q-Cytochrome-c ReductaseCoenzyme QH2-Cytochrome-c ReductaseCoenzymesColon CancerColon CarcinomaColon NeoplasmsColon TumorColonic MassColonic NeoplasmsColonic TumorColorectal CancerColorectal NeoplasmsColorectal TumorsCommon NeoplasmCommon TumorCommunicationComplex IIICytochrome b-c2 OxidoreductaseDataDeathDevelopmentDihydroubiquinone-Cytochrome-c ReductaseElectron MicroscopyElectron TransportElectron Transport Complex IIIElectronsEndoplasmic ReticulumEnzyme CofactorsEnzyme GeneEnzymesEpitheliumErgastoplasmFellowshipFoundationsGEM modelGEMM modelGeneticGenetic ScreeningGenetically Engineered MouseGoalsHomeostasisHypoxiaHypoxicHypoxic tumorImageIn VitroIntermediary MetabolismIntestinalIntestinesInvestigatorsIonsKnowledgeLarge Bowel TumorLarge Intestine NeoplasmLarge Intestine TumorLipidsMaintenanceMalignant CellMalignant NeoplasmsMalignant TumorMentorshipMetabolicMetabolic PathwayMetabolic ProcessesMetabolismMetaplasiaMetaplastic ChangeMethodsMiceMice MammalsMitochondriaModelingMolecularMonitorMurineMusNegative Beta ParticleNegatronsOrganellesOrganoidsOxidation-ReductionOxidative PhosphorylationOxidative Phosphorylation PathwayOxygen DeficiencyPathway interactionsPatientsPhasePhysiological HomeostasisPostdocPostdoctoral FellowPre-Clinical ModelPreclinical ModelsPrincipal InvestigatorProcessProgenitor CellsProliferatingPyrimidineQH(2)-Cytochrome-c ReductaseQH(2)-Ferricytochrome-c OxidoreductaseReactionRedoxRegulationReporterRepressionResearchResearch AssociateResearch PersonnelResearch ProposalsResearchersRespirationRoleSamplingScanning Electron MicroscopyScienceShapesSiteSterolsStimulusSystemTherapeuticTrainingTumor CellUbihydroquinone-Cytochrome-c ReductaseUbiquinol-Cytochrome-c ReductaseUbiquinol-ferricytochrome-c oxidoreductaseUbiquinoneUbiquinone-Cytochrome b-c2 OxidoreductaseWorkadipogenesisbiosynthesisbowelcancer cellcancer cell metabolismcancer in the coloncancer metabolismcancer microenvironmentcancer progressioncareercareer developmentcellular differentiationclustered regularly interspaced short palindromic repeats screencoenzyme analogcolon cancer cell linecolon cancer patientscolon neoplasiacolorectal cancer cell linecolorectal cancer patientscolorectal cancer progressioncolorectal neoplasiacomplex IVdevelopmentaldrivingelectron transfergenetically engineered mouse modelgenetically engineered murine modelgenome scalegenome-widegenomewidegraduate schoolimagingimproved outcomein vivoin vivo Modelinduced Creinducible Creinnovateinnovationinnovativeknowledge baselarge bowel neoplasmlipid biosynthesislipidomicslipogenesismalignancymetabolic fitnessmetabolism measurementmetabolomicsmetabonomicsmitochondrialmouse modelmurine modelneoplasm progressionneoplasm/cancerneoplastic cellneoplastic progressionnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetoxidationoxidation reduction reactionpathwaypharmacologicpost-docpost-doctoralpost-doctoral traineepressureprogenitor cell expansionprogenitor expansionresearch associatesrespiratory mechanismresponseresponse to therapyresponse to treatmentsocial rolestem and progenitor cell expansionstem cell expansionstem cellsstressortherapeutic responsetherapy responsetreatment responsetreatment responsivenesstumortumor cell metabolismtumor growthtumor hypoxiatumor metabolismtumor microenvironmenttumor progression
Description preview
PROJECT SUMMARY
Colorectal cancers (CRC) are characterized as having a hierarchical organization requiring proliferating and
de-differentiated stem cells to maintain tumor growth and progression. Cellular plasticity underlying colorectal
cancer is essential for a process which occurs following selective pressures of the tumor microenvironment
and…
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