grant
Inter-kingdom interactions of Salmonella Typhimurium and Candida albicans in the gut
Organization UNIVERSITY OF ILLINOIS AT CHICAGOLocation Chicago, UNITED STATESPosted 9 Nov 2023Deadline 31 Oct 2028
NIHUS FederalResearch GrantFY202621+ years old3,7,11-trimethyl-2,6,10-dodecatrien-1-olAdultAdult HumanAntibiotic ResistanceBacteriaBacterial AdhesinsBindingBody Weight decreasedC albicansC. albicansC.albicansCandidaCandida albicansCausalityCecumCell BodyCell surfaceCellsClinical ResearchClinical StudyCo-cultureCocultivationCocultureCoculture TechniquesColonCrohn diseaseCrohn'sCrohn's diseaseCrohn's disorderDataDiseaseDisorderEpithelial CellsEpitheliumEtiologyExhibitsFarnesolFungal ComponentsGI microbiomeGastroenteritisGene ExpressionGenesGlucansGlucose PolymerGnotobioticGnotobioticsGoalsGranulomatous EnteritisHealthHumanHyphaeImmuneImmune infiltratesImmune responseImmunesImmunomodulationIn VitroInfectionInflammatoryInflammatory ResponseInvadedLiverMacrophageMediatingMiceMice MammalsMicrobeMicroscopyModelingModern ManMolecular InteractionMoniliaMurineMusMφParasitesPathogenesisPathogenicityPathway interactionsPatientsPersonsPhagocytosisPolyglucosesProcessProteinsRNA SeqRNA sequencingRNAseqReceptor ProteinResistance to antibioticsResistant to antibioticsRoleS entericaS enterica serovar Paratyphi AS enterica serovar TyphiS enterica serovar TyphimuriumS paratyphiS typhiS typhimuriumS typhosaS. entericaS. enterica TyphimuriumS. enterica serovar Paratyphi AS. enterica serovar TyphiS. enterica serovar TyphimuriumS. paratyphiS. typhiS. typhimuriumS. typhosaSalmonella entericaSalmonella enterica TyphimuriumSalmonella enterica serovar Paratyphi ASalmonella enterica serovar TyphiSalmonella enterica serovar TyphimuriumSalmonella infectionsSalmonella paratyphiSalmonella paratyphi ASalmonella typhiSalmonella typhimuriumSalmonella typhosaSalmonellosisSeverity of illnessSignaling MoleculeSpleenSpleen Reticuloendothelial SystemSystemic infectionTestingToxinVirulenceVirusWeight LossWeight ReductionYeastsadhesinadulthoodantibiotic drug resistanceantibiotic resistantbacteria pathogenbacterial pathogenbiofilm communitybody weight lossbowel inflammationcausationco-infectioncoinfectioncytokinedectin 1digestive tract microbiomedisease causationdisease modeldisease severitydisorder modeleleocolitisenteric microbiomefood-bornfood-bornefoodbornfoodbornefungal microbiotafungusgastrointestinalgastrointestinal microbiomegut inflammationgut microbiomegut-associated microbiomehepatic body systemhepatic organ systemhost responseimmune cell infiltrateimmune modulationimmune regulationimmune system responseimmunologic reactivity controlimmunological statusimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponsein vivoinflamed bowelinflamed gutinflamed intestineintestinal biomeintestinal inflammationintestinal microbiomemicrobialmicrobiome community compositionmicrobiome componentsmicrobiome compositionmicrobiome membersmicrobiome species compositionmicrobiome structuremixed species biofilmmortalitymouse modelmulti-microorganism biofilmmultispecies biofilmmurine modelmycobiotapathogenpathogenic bacteriapathogenicity genepathwaypolymicrobial biofilmquorum sensingreceptorregional enteritisresponsesocial roletranscriptome sequencingtranscriptomic sequencingvirulence genevirulent genewt-loss
Description preview
PROJECT SUMMARY
Polymicrobial infections are a significant health concern to humans. Multi-species biofilms exhibit greatly
increased antibiotic resistance, and systemic infections with more than one etiologic agent are difficult to treat
and often more lethal than infections with a single pathogen. Salmonella enterica serovar Typhimurium (STm)
is…
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