grant
Integrative multivariate association and genomic analyses
Organization UNIVERSITY OF CHICAGOLocation CHICAGO, UNITED STATESPosted 1 Aug 2024Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AD dementiaAccountingAddressAffectAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaBody TissuesBrain DiseasesBrain DisordersBrain MappingCardiovascular DiseasesCell BodyCellsComplementComplement ProteinsComplexComputer softwareDNA MethylationDataData AnalysesData AnalysisData SourcesDetectionDevelopmentDiseaseDisorderEncephalon DiseasesEthnic OriginEthnicityExposure toFunctional RNAGTExGWA studyGWASGene ExpressionGene variantGenesGeneticGenetic DiversityGenetic VariationGenetic studyGenomicsGenotypeGenotype-Tissue Expression ProjectHeterogeneityHumanIntracranial CNS DisordersIntracranial Central Nervous System DisordersJointsLinkMapsMeasuresMendelian randomizationMethodsMethylationModelingModern ManNoncoding RNANontranslated RNAPatternPredispositionPrimary Senile Degenerative DementiaQTLQuantitative Trait LociRegulationResearch ResourcesResolutionResourcesRiskRisk FactorsRisk-associated variantSamplingSoftwareSourceSusceptibilityTestingTissuesUntranslated RNAValidationVariantVariationallelic variantcardiovascular disordercell typecomplementationdata interpretationdevelop softwaredeveloping computer softwaredevelopmentaldisease riskdisorder riskgenetic variantgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic variantglobal gene expressionglobal transcription profilehuman tissueimprovedinnovateinnovationinnovativeinsightinstrumentmembermethod developmentmethylomemolecular phenotypemultiomicsmultiple omicsnoncodingpanomicsprimary degenerative dementiaresolutionsrisk allelerisk generisk genotyperisk locirisk locusrisk variantsenile dementia of the Alzheimer typesoftware developmentstatisticssupervised learningsupervised machine learningtraittranscriptomevalidationswhole genome association analysiswhole genome association study
Description preview
Recently, as part of the enhancing Genotype Tissue-Expression (eGTEx) project, methylome data on subsets of GTEx samples (N=987) from nine tissue types of 424 subjects have been generated by co-I Pierce’s lab to complement existing expression quantitative trait locus (eQTL) data. As part of eGTEx, our group conducted the standard methylation QTL…
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