grant
Integration of Immunologic Phenotyping with Computational Approaches to Predict Clinical Trajectory in Septic Patients
Organization PENNSYLVANIA STATE UNIV HERSHEY MED CTRLocation HERSHEY, UNITED STATESPosted 1 Aug 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025Academic Medical CentersAcuteAdjuvant TherapyAffectApplications GrantsAssayAwardBioassayBiological AssayBody TissuesCancer TreatmentCaringCell BodyCell IsolationCell SegregationCell SeparationCell Separation TechnologyCellsCessation of lifeChronicClinicalClinical ResearchClinical StudyComplexCritical IllnessCritically IllDataDeathDevelopmentDiseaseDisorderDysfunctionEpidemicFunctional disorderGoalsGrantGrant ProposalsHealth Care CostsHealth CostsHumanIatrogenesisImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune ToleranceImmune responseImmunesImmunoactivatorsImmunoadjuvantsImmunochemical ImmunologicImmunologicImmunologic AdjuvantsImmunologic DiseasesImmunologic ToleranceImmunologicalImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImmunologicallyImmunologicsImmunopotentiatorsImmunostimulantsInflammationInvestigatorsLong-term infectionMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMeasurementMedicalMicrofluidicsModern ManMorbidityMorbidity - disease rateMyeloid CellsMyeloid-derived suppressor cellsNIGMSNational Institute of General Medical SciencesOperative ProceduresOperative Surgical ProceduresPBMCPatientsPeripheral Blood Mononuclear CellPhenotypePhysiopathologyPre-Clinical ModelPreclinical ModelsPreclinical TestingResearchResearch PersonnelResearch PriorityResearchersScientistSecondary toSepsisSurgicalSurgical InterventionsSurgical ProcedureSyndromeTechniquesTestingTissuesTranslatingUniversity Medical CentersWhole Bloodadjuvant treatmentanti-cancer therapyantisepsis treatmentburden of diseaseburden of illnesscancer therapycancer-directed therapycell sortingchronic infectionclinical careclinical predictorsclinical riskcytokinedevelopmentaldisease burdenhost responsehuman modeliatrogeniciatrogenicallyiatrogenicityimmune system responseimmune system toleranceimmune unresponsivenessimmunological paralysisimmunoresponseimmunosuppressive myeloid cellsin vitro Modelindividuals with sepsismetabolism measurementmetabolomicsmetabonomicsmodel of humanmortalitymyeloid suppressor cellsmyeloid-derived suppressive cellsnovelparticipant enrollmentpathophysiologypatient enrollmentpatients with sepsispeople with sepsispersistent infectionpoint of care testingpre-clinical testingprognosticprognostic abilityprognostic powerprognostic utilityprognostic valueprospectiverecruitresponsesecondary infectionsepsis caresepsis groupssepsis interventionssepsis managementsepsis patientssepsis populationsepsis subjectssepsis therapeuticssepsis therapysepsis treatmentseptic groupseptic individualsseptic patientsseptic peopleseptic populationseptic subjectseptic therapyseptic treatmentsubjects with sepsissuppressive myeloid cellssurgerytertiary caretheoriestooltranscriptomicstreat sepsistrial enrollmentµfluidic
Description preview
Project Summary/Abstract
Sepsis is a global epidemic with a high patient morbidity and mortality, and it accounts for staggering
healthcare costs both within the US and worldwide. Clinicians caring for septic patients are unable to
distinguish between septic patients who will rapidly recover and those patients who will develop a prolonged
disease…
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