grant
Integrating multi-omics data to understand the heterogeneity of preeclampsia and long-termpostpartum hypertension
Organization UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAHLocation SALT LAKE CITY, UNITED STATESPosted 5 Sept 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY20251st trimesterAccountingActive Follow-upAddressAffectApoplexyAsianBlackBlack raceBlood PlasmaBostonBrain Vascular AccidentCardiac healthCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCaucasian FemalesCaucasian WomenCell BodyCellsCells Placenta-TissueCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCessation of lifeClinicalClinical ResearchClinical StudyCohort AnalysesCohort AnalysisCohort StudiesColombiaComplexConcurrent StudiesCord BloodDataData SetDeathDevelopmentDiabetes MellitusDimensionsDiseaseDisorderDysfunctionEPH GestosisEarly Placental PhaseEnvironmental FactorEnvironmental Risk FactorEpidemiologic ResearchEpidemiologic StudiesEpidemiological StudiesEpidemiology ResearchEquityFaceFactor AnalysesFactor AnalysisFemale HealthFirst Pregnancy TrimesterFirst TrimesterFunctional disorderFundingFutureGene ExpressionGene TargetingGene variantGene x Environment InteractionGenesGeneticGenetic MarkersGenomicsGenotypeGestationGoalsGxE interactionHealthHeart VascularHeart failureHeart healthHeterogeneityHypertensionImageIncidenceInterventionInvestigationLong-term Follow-upMachine LearningMaternal MortalityMediatorMendelian randomizationMeta-AnalysisModelingMolecularMonitorMorbidityMorbidity - disease rateMothersMultiomic DataNHLBINational Heart, Lung, and Blood InstituteNormal PlacentomaNulliparasNulliparityNulliparousOnset of illnessOrganOutcomeOutcome StudyParentsPathway interactionsPerinatal MortalitiesPerinatal lethalityPerinatal mortality demographicsPhenotypePhysiopathologyPlacentaPlacenta Embryonic TissuePlacentomePlasmaPlasma SerumPostpartum PeriodPre-EclampsiaPreeclampsiaPregnancyPregnancy OutcomePregnancy ToxemiasProteinsProteinuria-Edema-Hypertension GestosisProteomicsQTLQuantitative Trait LociRNA SeqRNA sequencingRNAseqResearchReticuloendothelial System, Serum, PlasmaRiskRisk FactorsRisk-associated variantRoleSamplingSeveritiesSeverity of illnessSouth AsianStandardizationStressStrokeSurvivorsSyndromeSystemTOPMedTherapeutic StudiesTherapy ResearchTimeTrans-Omics for Precision MedicineUmbilical Cord BloodVariantVariationVascular DiseasesVascular DisorderVascular Hypertensive DiseaseVascular Hypertensive DisorderWhite FemalesWhite WomenWomanWomen's HealthWorkactive followupadverse pregnancy outcomeallelic variantbiobankbiorepositoryblack femaleblack womenblood vessel disorderbrain attackcardiac failurecardiovascular effectscell typecerebral vascular accidentcerebrovascular accidentcirculatory systemclinical predictorscohortcomputer based predictiondata integrationdata resourcedeprivationdevelopmentaldiabetesdifferential expressiondifferentially expresseddisease onsetdisease severitydisorder onsetdisparities in racedisparity due to racedisparity in ethnicentire genomeenvironment effect on geneenvironmental riskepidemiologic investigationepidemiology studyethnic based disparityethnic disadvantageethnic disparityethnic diversityethnic inequalityethnic inequityethnically diverseethnicity disparityfacesfacialfetalfetal cord bloodfollow upfollow-upfollowed upfollowupfull genomegene biomarkergene environment interactiongene expression biomarkergene markergene signature biomarkergenetic architecturegenetic biomarkergenetic variantgenome scalegenome sequencinggenome-widegenomewidegenomic varianthigh blood pressurehigh dimensional datahigh riskhyperpiesiahyperpiesishypertensive diseasehypertensive disorderimagingimprovedinequality due to raceinequity due to raceinnovateinnovationinnovativeinsightinterestlife spanlifespanlong-term followuplow-frequency mutationmachine based learningmaternal adipositymaternal deathmaternal obesitymortalitymultidimensional datamultidimensional datasetsmultiomicsmultiple omic datamultiple omicsnew diagnosticsnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynext generation diagnosticsnovel diagnosticsnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpanomicsparentpathophysiologypathwayperinatal deathsplacental trophoblastspost-partumpre-eclampticpredictive modelingpregnancy toxemia/hypertensionprogramsprospectivepsychosocialpublic health relevancerace based disparityrace based inequalityrace based inequityrace disparityrace related disparityrace related inequalityrace related inequityracial disparityracial diversityracial inequalityracial inequityracially diverseracially unequalrare allelerare mutationrare variantreproductiveresponserisk allelerisk generisk genotyperisk locirisk locusrisk variantsocialsocial rolestrokedstrokestranscriptional differencestranscriptome sequencingtranscriptomic sequencingtrophoblastvascular dysfunctionvasculopathyweb toolweb-based toolwhole genome
Description preview
PROJECT SUMMARY
Preeclampsia (PE) is a pregnancy-specific syndrome of progressive vascular dysfunction that leads to escalating
hypertension and extensive maternal organ damage, which can ultimately result in death. Occurring in 5-8% of
pregnancies worldwide, PE is a leading cause of both maternal and perinatal mortality. Beyond the short-term…
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