grant
Integrating Multi-Modal Data and Biomechanics in COPD: Toward Robust and Interpretable Biomarkers for Disease Subtyping and Progression
Organization BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)Location BOSTON, UNITED STATESPosted 1 May 2018Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY2025ARDSAcute Respiratory DistressAcute Respiratory Distress SyndromeAdult ARDSAdult RDSAdult Respiratory Distress SyndromeAffectAlveolar wallAmericanAreaBehaviorBehavioralBiologicalBiological MarkersBiomechanicsBiopsyBloodBlood Reticuloendothelial SystemBody TissuesCAT scanCOPDCT Lung ScreeningCT X RayCT XrayCT imagingCT scanCell BodyCell-Extracellular MatrixCellsChronic Obstruction Pulmonary DiseaseChronic Obstructive Lung DiseaseChronic Obstructive Pulmonary DiseaseCollagen FiberComputed TomographyComputing MethodologiesDa Nang LungDataData SetDevelopmentDiagnosisDiseaseDisease PathwayDisease ProgressionDisease VectorsDisorderDoseECMEconomic BurdenElastic TissueEmphysemaExtracellular MatrixFEVtForced Expiratory VolumeForced Vital CapacityForced expiratory volume functionGeneticGenetic PredispositionGenetic Predisposition to DiseaseGenetic SusceptibilityGenetic propensityGenomicsGenotypeGoalsHigh Resolution Computed TomographyIllness impactImageIndividualInherited PredispositionInherited SusceptibilityJointsLinkLungLung CAT ScanLung CTLung CT scanLung DiseasesLung Function TestsLung ParenchymaLung Respiratory SystemLung TissueMeasurementMeasuresMediationMethodsModalityModelingModernizationMonitorMultiomic DataNegotiatingNegotiationOnset of illnessOrganPaintPathway interactionsPatientsPatternPlayProcessProgressive DiseasePropertyProtocolProtocols documentationPulmonary DiseasesPulmonary DisorderPulmonary EmphysemaPulmonary function testsRNA SeqRNA sequencingRNAseqRadiographyResolutionRibsRiskRoentgenographyRoleRuptureSeveritiesSeverity of illnessShock LungSmokingSpirometryStiff lungStructureStructure of parenchyma of lungTechniquesTechnologyTimed Forced Vital CapacityTimed Vital CapacityTissuesTomodensitometryTrainingTreatment EfficacyVital capacityX-Ray CAT ScanX-Ray Computed TomographyX-Ray Computerized TomographyXray CAT scanXray Computed TomographyXray computerized tomographyairflow limitationairflow obstructionairway epithelium inflammationairway inflammationairway limitationairway obstructionattenuationbio-markersbiologicbiologic markerbiomarkerbiomechanic modelingbiomechanic simulationbiomechanicalbiomechanical modelbiomechanical modelingbiomechanical simulationcatscanchronic obstructive pulmonary disorderclinical diagnosisclinical predictorscomputational methodologycomputational methodscomputed axial tomographycomputer based methodcomputer based predictioncomputer methodscomputer tomographycomputerized axial tomographycomputerized tomographycomputerized tomography lung screeningcomputing methoddata acquisitiondata acquisitionsdata diversitydata modelingdeep learningdeep learning based modeldeep learning methoddeep learning modeldeep learning strategydevelopmentaldisease of the lungdisease onsetdisease phenotypedisease severitydisease subgroupsdisease subtypedisorder of the lungdisorder onsetdisorder subtypediverse datadrug developmentemphysematousendophenotypeexplainable AIexplainable artificial intelligencegenetic etiologygenetic mechanism of diseasegenetic vulnerabilitygenetically predisposedgenomic datagenomic datasethigh dimensionalityhigh resolution CTimagingimaging biomarkerimaging markerimaging-based biological markerimaging-based biomarkerimaging-based markerimprovedin silicoindexinginsightinterpretable AIinterpretable artificial intelligenceintervention efficacylung computerized axial tomography scanlung computerized tomographylung computerized tomography scanlung disorderlung functionlung function declinemechanical forcemodel of datamodel the datamodeling of the datamulti-modal datamulti-modal datasetsmulti-modalitymultimodal datamultimodal datasetsmultimodalitymultiple omic dataneural networknon-contrast CTnon-invasive imagingnoncontrast CTnoncontrast computed tomographynoninvasive imagingnovelobstructed airflowobstructed airwayoptic imagingoptical imagingpathwaypredictive modelingpulmonary functionpulmonary function declineradiological imagingradiologistradiomicsresolutionsrespiratory airway obstructionrespiratory inflammationrespiratory tract inflammationrib bone structureself supervisedself supervised learningself supervisionsmall airways diseasesocial rolesystemic inflammationsystemic inflammatory responsetherapeutic efficacytherapy efficacytooltranscriptome sequencingtranscriptomic sequencingtranscriptomicswet lung
Description preview
Abstract
Chronic Obstructive pulmonary disease (COPD) is a devastating, progressive disease affecting 13
million Americans and 300 million globally. The disease is highly heterogeneous, with both behavioral
risk (e.g., smoking) and genetic predisposition. Patient-specific biomechanics also play a crucial role
in determining the progression of the…
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