grant

Integrating imaging and multi-omics data to infer single-cell 3D genome structures

Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 15 Mar 2026Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY20263-D3-D modeling3-Dimensional30 nm Chromatin Fiber30 nm Fiber3D3D modelingAddressArchitectureBar CodesBody TissuesBrainBrain Nervous SystemCell BodyCell ComponentsCell FunctionCell NucleusCell PhysiologyCell ProcessCell StructureCellsCellular FunctionCellular PhysiologyCellular ProcessCellular StructuresChromatinChromatin FiberClassificationComplexComputing MethodologiesDataDedicationsDetectionDimensionsEncephalonEngineering / ArchitectureEnhancersEnvironmentFixationFrequenciesGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGenesGenetic TranscriptionGenomeGenomic SegmentGenomicsGoalsGrantImageImaging technologyKnowledgeLocationMapsMethodsMiceMice MammalsModelingMorphologyMouse ES CellMouse ESCMouse Embryonic ProgenitorMouse Embryonic Stem CellsMultiomic DataMurineMusNational Institutes of HealthNerve CellsNerve UnitNeural CellNeurocyteNeuronsNon-Polyadenylated RNANuclearNucleusPlayPolymersPopulationPositionPositioning AttributePropertyRNARNA ExpressionRNA Gene ProductsResolutionRibonucleic AcidRoleShapesStructureStructure-Activity RelationshipSubcellular ProcessSystematicsTechniquesTechnologyTimeTissuesTranscriptionTranscriptional ControlTranscriptional RegulationUnited States National Institutes of HealthVariantVariationbarcodecell imagingcell typecellular imagingchemical structure functioncomputational methodologycomputational methodscomputer based methodcomputer methodscomputing methoddata integrationentire genomeepigenetic memoryexperienceexperimentexperimental researchexperimental studyexperimentsfull genomegene functiongenome scalegenome segmentgenome-widegenomewidegenomic datagenomic datasetgenomic regionhigh definitionhigh-resolutionimagingimaging approachimaging based approachimprovedinsightmESCmembermultiomicsmultiple omic datamultiple omicsmultiplexed imagingmurine ES cellsmurine ESCmurine embryonic progenitormurine embryonic stem cellneuronalpanomicspolymerpolymericpopulation basedpreventpreventingpromoterpromotorresolutionssample fixationsocial rolestructure function relationshipsuperresolution microscopythree dimensionalthree-dimensional modelingtooluser friendly computer softwareuser friendly softwarewhole genome
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PROJECT SUMMARY/ABSTRACT
The three-dimensional organization of eukaryotic genomes plays a crucial role in transcriptional regulation and

cellular functions. However, current genome structure models, primarily derived from genomic data, have

significant limitations. They lack precise physical dimensions, fail to capture nuclear morphologies…

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Integrating imaging and multi-omics data to infer single-cell 3D genome structures — UNIVERSITY OF CALIFORNIA LOS ANGELE | Dev Procure