grant
Integrating dynamic cell behaviors to drive cranial morphogenesis
Organization NORTH CAROLINA STATE UNIVERSITY RALEIGHLocation RALEIGH, UNITED STATESPosted 1 Mar 2026Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAdoptedApicalBehaviorBiologic ModelsBiological ModelsBody TissuesCell BodyCell Communication and SignalingCell ShapeCell SignalingCell divisionCellsCephalicComplexCranialDark CellDefectDevelopmentDevelopmental BiologyDisparateHealthHumanHuman DevelopmentIndividualIntercalated CellIntracellular Communication and SignalingLeadMiceMice MammalsModel SystemModelingModern ManMolecularMorphogenesisMorphologyMurineMusOrganOutcomePatternPb elementPerinatal MortalitiesPerinatal lethalityPerinatal mortality demographicsProcessRoleShapesSignal TransductionSignal Transduction SystemsSignalingSystemTissue imagingTissuesantagonismantagonistbiological signal transductioncell behaviorcellular behaviorconstrictiondevelopmentalexperimentexperimental researchexperimental studyexperimentsheavy metal Pbheavy metal leadhuman diseaseimaging approachimaging based approachmorphogenetic processmouse geneticsneural plateperinatal deathspolarized cellsocial rolespatial and temporalspatial temporalspatiotemporalthree dimensionaltranscriptomics
Description preview
Abstract
Functional development of the body plan and organs requires tissues to adopt the specific three-
dimensional morphologies required for function. Defects in tissue shape lead to functional deficits
with impacts ranging from reduced or absent organ function to peri-natal lethality. The complex
tissue shapes required for function are built…
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