grant
Integrated Transporter Elucidation Center
Organization RUTGERS BIOMEDICAL AND HEALTH SCIENCESLocation Newark, UNITED STATESPosted 14 Sept 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20253-D Imaging3D imagingABC Transport ProteinABC Transporter ProteinABC TransportersABC transportABC15ABCG2ABCG2 geneABCPATP-Binding Cassette TransportersATP-Binding Cassette, Sub-Family G (WHITE), Member 2 GeneATP-Binding Cassette, Sub-Family G, Member 2ATP-Binding Cassette, Subfamily G, Member 2ATP-binding cassette transportAccelerationActive Biologic TransportActive Biological TransportActive TransportAddressApplications GrantsBCRPBCRP1BindingBiologyBiomedical EngineeringBirthBreast Cancer Resistance ProteinCarrier ProteinsCell BodyCellsCells Placenta-TissueChemicalsChemistryClinicalClinical ResearchClinical StudyComputational BiologyComputer ModelsComputerized ModelsDNA TherapyDataData BasesData SetDatabasesDeveloping fetusDiscipline of obstetricsDiseaseDisorderDrug TherapyDrugsEST157481Endocrine Gland SecretionEndothelial CellsEngineeringEnsureEpidemicEpidemiologyErythrocyte/Hepatoma Glucose TransporterExclusionFetal DevelopmentFetusFibroblastsGLUTGLUT1Gene Transfer ClinicalGeneralized GrowthGeneticGenetic InterventionGestationGlucose Transporter 1GoalsGovernmentGrant ProposalsGrowthHealth CareHealthy People 2020HormonesHumanIVIVEIn VitroInfantInfrastructureInstitutionInvestigatorsMRXMXR1Machine LearningMaternal HealthMaternal Health ServicesMaternal MortalityMaternal-fetal medicineMeasuresMedicationMedicineMitoxantrone Resistance ProteinModelingModern ManMolecular InteractionNormal PlacentomaNutrientNutritionObstetricsOutcomeParturitionPathologicPathologyPerinatalPeripartumPh D studentPh D. studentPh. D. studentPh.D studentPh.D. studentPhD studentPhD. studentPharmaceutical AgentPharmaceutical PreparationsPharmaceuticalsPharmacologic SubstancePharmacological SubstancePharmacological TreatmentPharmacologyPharmacotherapyPlacentaPlacenta Embryonic TissuePlacenta-Specific ATP-Binding Cassette TransporterPlacentomePostdocPostdoctoral FellowPregnancyPregnant WomenPropertyProteinsProteomicsPublic HealthRegulationResearchResearch AssociateResearch PersonnelResearch ResourcesResearchersResourcesRisk AssessmentSLC2A1SLC2A1 geneScientistSolute Carrier Family 2, Facilitated Glucose Transporter, Member 1SystemTestingTherapeuticTherapeutic HormoneTherapeutic InterventionThree-Dimensional ImagingTissue GrowthToxic effectToxicant exposureToxicitiesTrainingTranslational ResearchTranslational ScienceTransport Protein GeneTransport ProteinsTransporter ProteinUphill TransportVascularizationXenobioticsbio-engineeredbio-engineersbioengineeringbiological engineeringcareerchip modelchip systemcohortcomputational modelingcomputational modelscomputer based modelscomputer biologycomputer sciencecomputerized modelingdata basedeep learningdeep learning based neural networkdeep learning methoddeep learning neural networkdeep learning strategydeep neural netdeep neural networkdemographicsdiet supplementdietary supplementsdoctoral studentdrug dispositiondrug efficacydrug interventiondrug treatmentdrug/agentepidemiologicepidemiologicalexpectant motherexpectant womenexpecting motherexpecting womenextracellular vesiclesfetalgene repair therapygene therapygene-based therapygenetic therapygenomic therapyhealth care for mothershealth of the motherimprovedin silicoin vitro in vivo extrapolationin vitro to in vivo extrapolationindividuals who are pregnantinhibitorinnovateinnovationinnovativeinternet portalintervention therapyknowledgebasemachine based learningmaternal deathmaternal health carematernal morbiditymicrophysiologic modelmicrophysiologic platformmicrophysiologic systemmicrophysiology modelmicrophysiology platformmicrophysiology systemmother health carenew approachesnovelnovel approachesnovel strategiesnovel strategynutritional supplementon a chipon chipon-line portalonline portalontogenypeople who are pregnantperinatal healthpharmaceuticalpharmaceutical interventionpharmacokinetic modelpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsplacental transferpost-docpost-doctoralpost-doctoral traineepregnant femalespregnant motherspregnant peoplepregnant populationsresearch associatessexsolutesuccesssynergismthose who are pregnanttoxic exposuretoxicanttraining opportunitytranslation researchtranslational investigationtrophoblastundergradundergraduateundergraduate studentweb portalweb-based portalwomen who are pregnant
Description preview
PROJECT SUMMARY/ABSTRACT
Given their physiochemical properties, medications and dietary supplements often require active transport using
solute carriers (SLC) and ATP-binding cassette (ABC) transporters to cross trophoblast barriers. These same
transporters are also involved in the delivery of nutrients to the fetus and one unintentional…
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