grant
Integrated Therapies for Alcohol use in Alcohol-associated Liver Disease (ITAALD) - Virginia Commonwealth University
Organization VIRGINIA COMMONWEALTH UNIVERSITYLocation RICHMOND, UNITED STATESPosted 1 Aug 2018Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20251, 2-DehydrocortisoneAddressAffectAlcohol DrinkingAlcohol associated hepatitisAlcohol consumptionAlcohol hepatitisAlcohol induced hepatitisAlcohol related hepatitisAlcoholic HepatitisAlcoholic Liver DiseasesAncillary StudyAntimicrobial EffectAntioxidantsApoptoticBehavior Conditioning TherapyBehavior ModificationBehavior TherapyBehavior TreatmentBehavioralBehavioral Conditioning TherapyBehavioral ModificationBehavioral TherapyBehavioral TreatmentBiological Specimen BanksBiological Substance BanksCaringCephalinsChimera ProteinChimeric ProteinsClinicalClinical DataClinical TrialsCollaborationsCollectionCombined Modality TherapyCompensationConditioning TherapyDataData BanksData BasesDatabanksDatabasesDehydrocortisoneDelta(1)-CortisoneDeltacortisoneDeltadehydrocortisoneDiagnosisDrug TherapyEligibilityEligibility DeterminationEtOH drinkingEtOH useEthanol-induced hepatitisEthanolamine PhosphoglyceridesEthanolamineglycerophospholipidsEvaluationFDA approvedFundingFusion ProteinGlucocorticoidsGuidelinesHeavy DrinkingHepatic DisorderHepatitisIL-1 ReceptorsIL-1raIL-22IL1 ReceptorsIL1 febrile inhibitorIL1RNIndividualInformaticsInterleukin-1 Receptor AntagonistInterleukin-1 ReceptorsInterventionInvestigatorsKnowledgeLiverLiver diseasesMeasuresMetacortandracinMorbidityMorbidity - disease rateMultimodal TherapyMultimodal TreatmentN-acetylhomotaurineO-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)-ethanolamineObservation researchObservation studyObservational StudyObservational researchOutcomePatient PreferencesPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPatternPharmacological TreatmentPharmacotherapyPhasePhosphatidylethanolaminePhysiciansPrednisonePrednisonumProtocol ScreeningQOCQOLQuality of CareQuality of lifeRandomizedRandomized, Controlled TrialsRegression AnalysesRegression AnalysisRegression DiagnosticsReportingResearch DesignResearch PersonnelResearch ResourcesResearchersResourcesSequential Multiple Assignment Randomized TrialSiteStatistical RegressionSteroid CompoundSteroidsStudy TypeSurvivorsSystems BiologyTestingTherapeuticTranslational ResearchTranslational ScienceTransplantationUniversitiesVirginiaZincZn elementabstaining from alcoholabstaining from ethanolabstinence from alcoholabstinence from ethanolacamprosateacamprostatealcohol abstinencealcohol abuse therapyalcohol abuse treatmentalcohol induced hepatic injuryalcohol induced liver disorderalcohol induced liver injuryalcohol ingestionalcohol intakealcohol misusealcohol product usealcohol related liver diseasealcohol treatmentalcohol usealcohol use disorderalcohol-associated liver diseasealcohol-induced hepatic dysfunctionalcohol-induced liver diseasealcohol-induced liver dysfunctionalcohol-mediated liver dysfunctionalcohol-mediated liver injuryalcohol-related liver diseasealcoholic beverage consumptionalcoholic drink intakealcoholic liver injuryanakinraantagonismantagonistanti-microbial effectbehavior interventionbehavioral interventionbiological specimen repositorybiosample repositorybiospecimen bankbiospecimen repositorycare as usualcare outcomescatalystcohortcombination therapycombined modality treatmentcombined treatmentdata basedata depositorydata repositorydata set repositorydataset repositorydelta-Cortisonedrink heavilydrinkingdrug interventiondrug treatmentefficacy testingethanol abstinenceethanol consumptionethanol drinkingethanol induced hepatic injuryethanol induced liver disorderethanol induced liver injuryethanol ingestionethanol intakeethanol liver diseaseethanol misuseethanol product useethanol useethanol use disorderethanol-induced hepatic dysfunctionethanol-induced liver diseaseethanol-induced liver dysfunctionethanol-mediated liver dysfunctionethanol-mediated liver injuryevidence baseexcessive alcohol consumptionexcessive alcohol ingestionexcessive alcohol intakeexcessive drinkingexcessive ethanol ingestionextreme drinkinggroup counselinghealth care outcomeshealthy volunteerheavy alcohol usehepatic body systemhepatic diseasehepatic organ systemhepatopathyimprovedinterleukin 1 receptor antagonist proteininterleukin-22liver disorderlongitudinal databasemeetingmeetingsmortalitymotivational enhancement therapymotivational interviewmulti-modal therapymulti-modal treatmentnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetopen labelopen label studyoptimal therapiesoptimal treatmentspatient oriented outcomespatient populationpatient registrypharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsprimary end pointprimary endpointprospectiverandomisationrandomizationrandomized control trialrandomly assignedsafety assessmentsocial stigmaspecimen bankspecimen repositorystandard of carestigmastudy designtranslation researchtranslational investigationtransplanttreatment as usualtrial comparingunhealthy alcohol useurine IL-1 inhibitorurine interleukin 1 inhibitorurine-derived IL1 inhibitorusual care
Description preview
Severe alcohol-associated hepatitis (sAH) has high short-term mortality, yet it currently has no FDA-approved therapy. Although return to drinking impacts quality of life and mortality in these patients, available pharmacological treatments and behavioral therapies have not been widely utilized in the care of this patient population. An optimal…
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