grant
Integrated super-resolution CMR-deep learning to deconvolute passive and active causes of impaired relaxation
Organization TEXAS ENGINEERING EXPERIMENT STATIONLocation COLLEGE STATION, UNITED STATESPosted 6 Mar 2025Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY20264-dimensionalAblationAnimalsArchitectureAsymmetric Septal HypertrophyBehaviorBlood flowBody TissuesCardiacCardiac DiseasesCardiac DisordersCardiac Muscle MyosinsCardiac MyosinsCausalityCharacteristicsClinicalCollagenDataDeteriorationDevelopmentDiabetic mouseDiastolic heart failureDiseaseDisorderDysfunctionEchocardiogramEchocardiographyElementsEngineering / ArchitectureEtiologyEventFiberFour-dimensionalFunctional disorderHF with preserved ejection fractionHFpEFHeartHeart DiseasesHeart failureHereditary ventricular hypertrophyHeterogeneityHumanHypersensitivity skin testingHypertrophic CardiomyopathyHypertrophic Obstructive CardiomyopathyIdiopathic Hypertrophic Subvalvular StenosisIdiopathic hypertrophic subaortic stenosisImageImpairmentKI miceKineticsKnock-inKnock-in MouseLeftLeft VentriclesLeft ventricular structureLinkMeasuresMechanicsMethodist ChurchMethodistsMiceMice MammalsModelingModern ManMotionMurineMusMyBP-C proteinMyocardialMyocardiumOrganPatientsPhenotypePhosphorylationPhysiopathologyPlayPropertyProtein PhosphorylationRelaxationResearch SpecimenRoleSkin TestsSpecimenStressTechnologyTestingTherapeuticTimeTissuesTransthoracic EchocardiographyVentricularamyloid cardiomyopathyamyloid heart diseasecardiac MRIcardiac amyloidosiscardiac failurecardiac imagingcardiac magnetic resonance imagingcardiac motioncardiac musclecardiac scanningcausationcohortcustomized therapycustomized treatmentdeep learningdeep learning based modeldeep learning methoddeep learning modeldeep learning strategydevelopmentaldiabetes mouse modeldiabeticdiabetic cardiomyopathydiabetic cardiopathydiabetic cardiopathy diseasediabetic cardiopathy disorderdiabetic cardiovascular diseasediabetic cardiovascular disorderdisease causationheart disorderheart failure with preserved ejection fractionheart failure with preserved systolic functionheart imagingheart motionheart muscleheart scanningheart sonographyhemodynamicshypersensitivity testhypertensive cardiomyopathyhypertensive heart diseasehypertensive heart disorderhypertrophic myocardiopathyimagingimmunologic skin testimprovedin vivoindexingindividualized medicineindividualized patient treatmentindividualized therapeutic strategyindividualized therapyindividualized treatmentknockinknockin micemechanicmechanicalmicroscope imagingmicroscopic imagingmicroscopy imagingmimeticsmouse modelmurine modelmyosin-binding protein Cpathophysiologypatient specific therapiespatient specific treatmentpreserved ejection fraction heart failuresegregationsocial rolesuper high resolutionsuperresolutiontailored medical treatmenttailored therapytailored treatmentultra high resolutionultra resolutionultrafine resolutionunique treatment
Description preview
SUMMARY
Left ventricular (LV) diastolic dysfunction (LVDD) is a key contributor to the pathophysiology of several cardiac
diseases, including diabetic cardiomyopathy, hypertrophic cardiomyopathy, and heart failure with preserved
ejection fraction. LVDD has two common sequelae: restrictive filling and impaired LV relaxation (ILVR). The
restrictive…
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