grant
Integrated mechanisms of primary and chronic graft dysfunction following lung transplantation
Organization NORTHWESTERN UNIVERSITYLocation CHICAGO, UNITED STATESPosted 17 Sept 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025Acid RefluxAcidsActive Follow-upAcuteAffectAlloantibodiesAlveolar MacrophagesAssayAttenuatedBioassayBiological AssayBiological MarkersBiopsy SampleBiopsy SpecimenBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood monocyteBronchoalveolar Lavage FluidCD115CD115 GeneCOVID crisisCOVID epidemicCOVID pandemicCOVID-19 crisisCOVID-19 epidemicCOVID-19 eraCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 pandemicCOVID-19 periodCOVID-19 public health crisisCOVID-19 yearsCSF1CSF1 geneCSF1RCSF1R geneCSFMRCell BodyCellsChronicClinicalClinical DataColony Stimulating Factor 1 Receptor GeneCommunitiesComplement ActivationComplexCredentialingDataDetectionDysfunctionEpithelial CellsEsophageal RefluxEsophagusFunctional disorderGERDGastro-oesophageal RefluxGastroesophageal RefluxGastroesophageal reflux diseaseGeneticGoalsHourHumanImmuneImmunesInvestigatorsIsoantibodiesLifeLinkLungLung Alveolar EpitheliaLung DiseasesLung GraftingLung Respiratory SystemLung Tissue FibrosisLung TransplantationLung damageMCSFMGC31930Marrow NeutrophilMarrow monocyteMediatingMedicalMethodsMiceMice MammalsMitochondriaModern ManMolecularMurineMusNatureNeutrophil InfiltrationNeutrophil RecruitmentNeutrophilic GranulocyteNeutrophilic InfiltrateNeutrophilic LeukocyteOrganOutcomePathologicPathway interactionsPatientsPhenotypePhysiologicPhysiologicalPhysiologyPhysiopathologyPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsProceduresPublishingPulmonary DiseasesPulmonary DisorderPulmonary FibrosisPulmonary GraftPulmonary MacrophagesPulmonary TransplantPulmonary TransplantationReagentRefractoryReproducibilityResearch PersonnelResearchersRespiratory EpitheliumRisk FactorsSARS-CoV-2 epidemicSARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 pandemicSARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicSalvage TherapySalvage-TxSevere Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 pandemicSeveritiesSolidStomachStructure of respiratory epitheliumTestingTissue SampleTransplant RecipientsTransplantationUniversitiesactive followupairway epitheliumallograft rejectionalveolar epitheliumaspirateattenuateattenuatesbio-markersbiologic markerbiological adaptation to stressbiomarkerc-FMSc-fms Genesc-fms Proto-Oncogenesclinical phenotypecohortcomplement pathway regulationcoronavirus disease 2019 crisiscoronavirus disease 2019 epidemiccoronavirus disease 2019 global health crisiscoronavirus disease 2019 global pandemiccoronavirus disease 2019 health crisiscoronavirus disease 2019 pandemiccoronavirus disease 2019 public health crisiscoronavirus disease crisiscoronavirus disease epidemiccoronavirus disease pandemiccoronavirus disease-19 global pandemiccoronavirus disease-19 pandemicdisease of the lungdisorder of the lungepithelial repairfibrosis in the lungfollow upfollow-upfollowed upfollowupgastricgraft dysfunctionimprovedinnovateinnovationinnovativelife-threatening COVIDlife-threatening COVID-19life-threatening SARS-CoV-2life-threatening coronavirus diseaselife-threatening coronavirus disease 2019life-threatening severe acute respiratory syndrome coronavirus 2lung allograftlung developmentlung disorderlung fibrosislung injurylung repairlung tissue repairlung transplantmitochondrialmitochondrial dysfunctionmonocytemortalitymouse modelmultiomicsmultiple omicsmurine modelneutrophilpanomicspathophysiologypathwayprogramspulmonary damagepulmonary injurypulmonary repairpulmonary tissue damagepulmonary tissue injuryreaction; crisisrecruitrespiratory tract epitheliumserious COVIDserious COVID-19serious SARS-CoV-2serious coronavirus diseaseserious coronavirus disease 2019serious severe acute respiratory syndrome coronavirus 2severe COVIDsevere COVID-19severe COVID19severe SARS-CoV-2severe acute respiratory syndrome coronavirus 2 global health crisissevere acute respiratory syndrome coronavirus 2 global pandemicsevere coronavirus diseasesevere coronavirus disease 19severe coronavirus disease 2019severe severe acute respiratory syndrome coronavirus 2small molecular inhibitorsmall molecule inhibitorstress responsestress; reactionsynergismtherapeutic targettransplanttransplant patient
Description preview
Lung transplantation is increasingly used to treat an expanding list of end-stage lung diseases, resulting in an
over >50% increase in the number of lung transplant procedures in the US in the last decade. Unfortunately,
survival following lung transplant is the worst amongst solid organs with only 80% and 50% of patients alive at 1
and 5 years,…
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