grant
Insulin Misfolding Dynamics and Insulin Signaling Dysfunction
Organization MC LAUGHLIN RESEARCH INSTITUTELocation GREAT FALLS, UNITED STATESPosted 1 Jan 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2026Adult-Onset Diabetes MellitusAffectAgeAgingAmericanAnimal ModelAnimal Models and Related StudiesAreaAssayAutoregulationBeta CellBeta SheetBindingBioassayBiological AssayBloodBlood CirculationBlood Reticuloendothelial SystemBloodstreamBody TissuesBolusBolus InfusionCaringCell BodyCell Communication and SignalingCell Culture TechniquesCell RespirationCell SignalingCellsCellular RespirationChronicClinicalD-GlucoseDataDegenerative Neurologic DisordersDextroseDiabetes MellitusDiabetic mouseDimethylbiguanidineDimethylguanylguanidineDiseaseDisorderDisparateDrugsDysfunctionEconomicsEntropyEnvironmentEnvironmental ExposureEquilibriumFaceFeedbackFosteringFunctional disorderGluconeogenesis InhibitionGlucoseGoalsHealthHealth CareHomeostasisHumanHumulin RHyperinsulinemiaHyperinsulinismImpairmentIn VitroIncidenceIndividualInsulinInsulin CellInsulin ReceptorInsulin Receptor Protein-Tyrosine KinaseInsulin ResistanceInsulin Secreting CellInsulin-Dependent Tyrosine Protein KinaseIntracellular Communication and SignalingKetosis-Resistant Diabetes MellitusKineticsLinkLiverLiver DysfunctionMT-bound tauMaturity-Onset Diabetes MellitusMedicationMetabolicMetabolic dysfunctionMetforminMethodsModelingModern ManMolecularMolecular Biology TechniquesMolecular InteractionMontanaN,N-dimethyl-imidodicarbonimidic diamideNAC precursorNIDDMNatureNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RObesityObservational StudyOutcomeOzempicPARK1 proteinPARK4 proteinPRNPPancreasPancreaticParalysis AgitansParkinsonParkinson DiseasePathway interactionsPatientsPharmaceutical PreparationsPhenotypePhysiological HomeostasisPhysiopathologyPlayPopulationPrPPrP ProteinsPrP genePrimary ParkinsonismPrion ProteinsPrion protein geneProcessProductionProteinsR-Series Research ProjectsR01 MechanismR01 ProgramReceptor ProteinRecombinantsRegular InsulinReporterReportingResearchResearch GrantsResearch InfrastructureResearch InstituteResearch Project GrantsResearch ProjectsRiskRisk FactorsRoleRuralRural CommunityRural HealthRybelsusSNCASNCA proteinSignal TransductionSignal Transduction SystemsSignalingSlow-Onset Diabetes MellitusStable Diabetes MellitusStructureSystemT2 DMT2DT2DMTechniquesTherapeuticThermodynamicThermodynamicsTimeTissue ProcurementsTissuesType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesWegovyWorka-syna-synucleinaberrant protein foldingabnormal protein foldingadiposityadult onset diabetesaerobic metabolismaerobic respirationage associated diseaseage associated disorderage associated impairmentage dependent diseaseage dependent disorderage dependent impairmentage related human diseaseage-related diseaseage-related disorderage-related impairmentagesalpha helixalpha synucleinalpha synuclein genealphaSP22amyloid assemblyamyloid formationamyloid structureasynbalancebalance functionbeta pleated sheetbiological signal transductionblood glucose regulationcareer developmentcell culturecell culturescorpulencedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdetection assaydiabetesdiabetes mouse modeldiabeticdrug/agenteconomicenthalpyexposure to environmental agentsexposure to environmental factorsexposure to environmental stimuliexposure to environmental substancesextracellularfacesfacialglucose controlglucose homeostasisglucose metabolismglucose regulationglucose transportglucose uptakeglycemic controlhepatic body systemhepatic organ systemin vivoinnovateinnovationinnovativeinsulin resistantinsulin secretioninsulin signalinginsulin toleranceketosis resistant diabetesmaturity onset diabetesmicrotubule bound taumicrotubule-bound taumodel of animalmouse modelmurine modelneurodegenerative illnessnon A-beta component of AD amyloidnon A4 component of amyloid precursornovelobservational research studyobservational surveyoxidative metabolismpathologic protein foldingpathophysiologypathwaypre-clinicalpre-clinical studypreclinicalpreclinical studyprotein foldingprotein misfoldingreceptorreceptor bindingreceptor boundresearch studyresponserural arearural locationrural regionsemaglutideside effectsocial rolesubcutaneoussubdermaltautau Proteinstau factortooltype 2 DMtype II DMtype two diabetesurban areaurban locationurban regionα synuclein geneα-helixα-synα-synucleinβ-Sheetβ-cellβ-cellsβ-pleated sheetβCellτ Proteins
Description preview
Type 2 diabetes mellitus (T2DM) is a chronic condition of dysregulation of glucose metabolism that affects millions
of Americans. In normal glucose homeostasis, insulin release acts as the key to enable entry of glucose into a
cell where it can be utilized in aerobic respiration to create ATP, the energy molecule of the cell. In those with…
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