grant
Insulin Misfolding Dynamics and Insulin Signaling Dysfunction
Organization MC LAUGHLIN RESEARCH INSTITUTELocation GREAT FALLS, UNITED STATESPosted 1 Jul 2025Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2025Adult-Onset Diabetes MellitusAffectAgeAgingAmericanAnimal ModelAnimal Models and Related StudiesAreaAssayAutoregulationBeta CellBeta SheetBindingBioassayBiological AssayBloodBlood CirculationBlood Reticuloendothelial SystemBloodstreamBody TissuesBolusBolus InfusionCaringCell BodyCell Communication and SignalingCell Culture TechniquesCell RespirationCell SignalingCellsCellular RespirationChronicClinicalD-GlucoseDataDegenerative Neurologic DisordersDextroseDiabetes MellitusDiabetic mouseDimethylbiguanidineDimethylguanylguanidineDiseaseDisorderDisparateDrugsDysfunctionEconomicsEntropyEnvironmentEnvironmental ExposureEquilibriumFaceFeedbackFosteringFunctional disorderGluconeogenesis InhibitionGlucoseGoalsHealthHealth CareHomeostasisHumanHumulin RHyperinsulinemiaHyperinsulinismImpairmentIn VitroIncidenceIndividualInsulinInsulin CellInsulin ReceptorInsulin Receptor Protein-Tyrosine KinaseInsulin ResistanceInsulin Secreting CellInsulin-Dependent Tyrosine Protein KinaseIntracellular Communication and SignalingKetosis-Resistant Diabetes MellitusKineticsLinkLiverLiver DysfunctionMT-bound tauMaturity-Onset Diabetes MellitusMedicationMetabolicMetabolic dysfunctionMetforminMethodsModelingModern ManMolecularMolecular Biology TechniquesMolecular InteractionMontanaN,N-dimethyl-imidodicarbonimidic diamideNAC precursorNIDDMNatureNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RObesityObservation researchObservation studyObservational StudyObservational researchOutcomePARK1 proteinPARK4 proteinPRNPPancreasPancreaticParalysis AgitansParkinsonParkinson DiseasePathway interactionsPatientsPharmaceutical PreparationsPhenotypePhysiological HomeostasisPhysiopathologyPlayPopulationPrPPrP ProteinsPrP genePrimary ParkinsonismPrion ProteinsPrion protein geneProcessProductionProteinsR-Series Research ProjectsR01 MechanismR01 ProgramReceptor ProteinRecombinantsRegular InsulinReporterReportingResearchResearch GrantsResearch InfrastructureResearch InstituteResearch Project GrantsResearch ProjectsRiskRisk FactorsRoleRuralRural CommunityRural HealthSNCASNCA proteinSignal TransductionSignal Transduction SystemsSignalingSlow-Onset Diabetes MellitusStable Diabetes MellitusStructureSystemT2 DMT2DT2DMTechniquesTherapeuticThermodynamicThermodynamicsTimeTissue ProcurementsTissuesType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesWorka-syna-synucleinaberrant protein foldingabnormal protein foldingadiposityadult onset diabetesaerobic metabolismaerobic respirationage associated diseaseage associated disorderage associated impairmentage dependent diseaseage dependent disorderage dependent impairmentage related human diseaseage-related diseaseage-related disorderage-related impairmentagesalpha helixalpha synucleinalpha synuclein genealphaSP22amyloid assemblyamyloid formationamyloid structureasynbalancebalance functionbeta pleated sheetbiological signal transductionblood glucose regulationcareer developmentcell culturecell culturescorpulencedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdetection assaydiabetesdiabetes mouse modeldiabeticdrug/agenteconomicenthalpyextracellularfacesfacialglucose controlglucose homeostasisglucose metabolismglucose regulationglucose transportglucose uptakeglycemic controlhepatic body systemhepatic organ systemin vivoinnovateinnovationinnovativeinsulin resistantinsulin secretioninsulin signalinginsulin toleranceketosis resistant diabetesmaturity onset diabetesmicrotubule bound taumicrotubule-bound taumodel of animalmouse modelmurine modelneurodegenerative illnessnon A-beta component of AD amyloidnon A4 component of amyloid precursornoveloxidative metabolismpathologic protein foldingpathophysiologypathwaypre-clinicalpre-clinical studypreclinicalpreclinical studyprotein foldingprotein misfoldingreceptorreceptor bindingreceptor boundresearch studyresponserural arearural locationrural regionside effectsocial rolesubcutaneoussubdermaltautau Proteinstau factortooltype 2 DMtype II DMtype two diabetesurban areaurban locationurban regionα synuclein geneα-helixα-synα-synucleinβ-Sheetβ-cellβ-cellsβ-pleated sheetβCellτ Proteins
Description preview
Type 2 diabetes mellitus (T2DM) is a chronic condition of dysregulation of glucose metabolism that affects millions
of Americans. In normal glucose homeostasis, insulin release acts as the key to enable entry of glucose into a
cell where it can be utilized in aerobic respiration to create ATP, the energy molecule of the cell. In those with…
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