grant
Insula-BNST Circuit Regulation of AUD
Organization WAKE FOREST UNIVERSITY HEALTH SCIENCESLocation WINSTON-SALEM, UNITED STATESPosted 5 Sept 2025Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025Absolute ethanolAbstinenceAddressAffectiveAlcohol Chemical ClassAlcohol DrinkingAlcohol abuseAlcohol consumptionAlcoholsAnteriorAnxietyAutomobile DrivingBed Nucleus of Stria TerminalisBehaviorBehavior DisordersBehavior-Related DisorderBehavior-Related ProblemBehavioralBiological MarkersBrain ConcussionCardiac DiseasesCardiac DisordersCell Communication and SignalingCell SignalingCentral LobeCerebral ConcussionClassificationClinicalCommotio CerebriComplexDecision MakingDependenceDetectionDiabetes MellitusDiagnosisDigital biomarkerDown-RegulationETOHElementsEquilibriumEtOH abuseEtOH drinkingEtOH useEthanolEthyl AlcoholExhibitsExpression SignatureFamilyFutureGene Expression ProfileGene TranscriptionGenesGenetic MarkersGenetic TranscriptionGoalsGrain AlcoholHeart DiseasesHigh PrevalenceHumanIndividualInsulaInsula of ReilInteroceptionInterventionIntracellular Communication and SignalingIsland of ReilLifestyle-Related DisorderLifestyle-Related ProblemLifestyle-related conditionLinkMeasurementMeasuresMediatingMental DepressionMethylcarbinolMiceMice MammalsModelingModern ManMolecularMolecular FingerprintingMolecular ProfilingMolecular TargetMurineMusNerve CellsNerve UnitNeural CellNeurobiologyNeurocyteNeuronsNoisePathway interactionsPatternPeripheralPhysiologicPhysiologicalPhysiologyPre-Clinical ModelPreclinical ModelsPredispositionPreventative measurePreventive measureProbabilistic ModelsProbability ModelsQuinineRNA ExpressionRNA SeqRNA sequencingRNA-seq using translating ribosome affinity purificationRNAseqRegulationResearchResistanceRewardsRiskRisk AssessmentRodentRodentiaRodents MammalsRoleSensorySignal TransductionSignal Transduction SystemsSignalingStatistical ModelsStressStria Terminalis NucleusStructure of terminal stria nuclei of preoptic regionSubstance Use DisorderSusceptibilitySynapsesSynapticSystematicsTRAP RNA sequencingTRAP RNA-seqTRAP-seqTestingTranscriptTranscriptionTranslating Ribosome Affinity Purification followed by RNA sequencingTranslating Ribosome Affinity Purification technology followed by RNA sequencingUpregulationaddictionaddictive disorderalcohol behavioralcohol co-abusealcohol cuealcohol exposedalcohol exposurealcohol induced behavioralcohol ingestionalcohol intakealcohol problemalcohol product usealcohol related behavioralcohol related cuealcohol usealcohol use disorderalcoholic beverage consumptionalcoholic drink intakebalancebalance functionbehavior responsebehavioral disorderbehavioral responsebinge alcohol consumptionbinge drinkingbio-markersbiologic markerbiological adaptation to stressbiological signal transductionbiomarkerclinical diagnosticscognitive assessmentcognitive controlcognitive testingconcussionconcussivedepressiondiabetesdiagnostic tooldigital markerdrinkingdrinking behaviordrivingemotion regulationemotional regulationepisodic drinkingethanol abuseethanol behaviorethanol consumptionethanol cueethanol drinkingethanol exposedethanol exposureethanol induced behaviorethanol ingestionethanol intakeethanol product useethanol related behaviorethanol useethanol use disorderexperienceexposed to alcoholexposed to ethanolexposure to alcoholexposure to ethanolgene biomarkergene expression biomarkergene expression patterngene expression signaturegene markergene signature biomarkergene signaturesgenetic biomarkergenetic signatureglobal gene expressionglobal transcription profilehazardous alcohol useheart disorderimaging biomarkerimaging markerimaging-based biological markerimaging-based biomarkerimaging-based markerimprovedin vivoinnovateinnovationinnovativeknock-downknockdownmedical diagnosticmolecular biomarkermolecular markermolecular profilemolecular signaturemouse modelmurine modelnegative affectnegative affectivityneural adaptationneural circuitneural circuitryneuroadaptationneurobiologicalneurocircuitryneuronalneuronal circuitneuronal circuitrypathwaypre-clinicalpre-clinical researchpreclinicalpreclinical researchpreventpreventingproblem alcohol useproblem drinkingproblematic alcohol consumptionproblematic alcohol usereaction; crisisrecruitresistantresponsereward processingrisk mitigationshRNAshort hairpin RNAsmall hairpin RNAsocial rolestatistical linear mixed modelsstatistical linear modelsstress related disorderstress responsestress; reactionstressorsubstance use and disordersynapsesynaptic circuitsynaptic circuitrytraittranscriptional profiletranscriptional signaturetranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomicstranslating ribosome affinity purification and RNA-sequencingtranslating ribosome affinity purification with RNA sequencing
Description preview
PROJECT SUMMARY
Alcohol use disorder (AUD) afflicts millions of individuals and their families. Current treatment options and
clinical diagnostic tools are limited, necessitating more research on the progression from casual use to AUD in
certain individuals. Identifying pre-AUD biomarkers, as is common practice with heart disease and diabetes,…
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