grant
Instructive roles of mesenchymal proteoglycans in hair follicle morphogenesis and maintenance
Organization STATE UNIVERSITY NEW YORK STONY BROOKLocation STONY BROOK, UNITED STATESPosted 3 Sept 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025AdhesionsBasement membraneBindingBiologicalBiological FunctionBiological MarkersBiological ProcessBiologyBody TissuesCUT&RUNCell AggregationCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell LocomotionCell MigrationCell MovementCell SignalingCell-Extracellular MatrixCell-to-Cell InteractionCellsCellular MigrationCellular MotilityCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseCollectionContracting OpportunitiesContractsCre driverDataDepositDepositionDermalECMEmbryo DevelopmentEmbryogenesisEmbryonic DevelopmentEngineeringErinaceidaeExtracellular MatrixFibrosisGene TranscriptionGeneralized GrowthGenesGenetic TranscriptionGoalsGrowthHairHair BulbHair FollicleHair bulb structureHair follicle structureHair shaft structureHedgehog (Hh) signal transduction pathwayHedgehogsImmunoblottingImpairmentIntegrin Signaling PathwayIntegrinsIntegrins Extracellular MatrixIntracellular Communication and SignalingInvestigationKnowledgeLigand BindingLigandsLinkLiteratureMaintenanceMapsMediatingMediatorMesenchymalMolecularMolecular InteractionMolecular Modeling Nucleic Acid BiochemistryMolecular Modeling Protein/Amino Acid BiochemistryMolecular ModelsMorphogenesisNamesNatural regenerationOutcomeParacrine CommunicationParacrine SignalingPlayProductionProliferatingProteinsProteoglycanRNA ExpressionRNA SeqRNA sequencingRNAseqReceptor ProteinRegenerationRegulationRoleSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSkinSurfaceTissue GrowthTissuesTranscriptionTranscriptional ControlTranscriptional RegulationWestern BlottingWestern Immunoblottingbehavior influencebehavioral influencebio-markersbiologicbiologic markerbiological signal transductionbiomarkercancer microenvironmentcell motilitycell typeexperimentexperimental researchexperimental studyexperimentsextracellulargain of functionhair shafthedgehog signalinghedgehog signaling pathwayhh signaling pathwayin vivoin vivo Modelinduced Creinducible Creinhibitorinsightkeratinocytelive cell imagelive cell imaginglive cellular imagelive cellular imagingloss of functionmigrationmolecular modelingmorphogenetic processmouse modelmurine modelnamenamednamingnovelontogenyoverexpressoverexpressionpapillapostnatalprotein blottingreceptorregeneratescaffoldscaffoldingsmoothened signaling pathwaysocial rolesuperresolution imagingtongue papillatooltranscriptome sequencingtranscriptomic sequencingtumor microenvironmentversican
Description preview
PROJECT SUMMARY
Hair is produced in the hair follicles. Hair follicle formation, cycling, and neogenesis relies on extensive cross-
talk between hair follicle keratinocytes and dermal papilla cells. This cross-talk is primarily mediated by
molecular signaling pathways. In classic models of molecular signaling, a ligand binds and activates a…
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