grant
Insights into Sickle Cell Trait and Sickle Cell Disease
Organization NATIONAL HUMAN GENOME RESEARCH INSTITUTELocation UNITED STATES
NIHUS FederalResearch GrantFY202521+ years oldAddressAdultAdult HumanAeroseb-HCAffectAfrican ancestryAfrican descentAgreementAlgorithmsAll of Us ProgramAll of Us Research ProgramAll of Us Research ProjectAmericanAnaerobic BacteriaAnemiaAnimalsAoURPApoplexyAttitudeB-globinBibliographyBiological MarkersBlood SerumBrain Vascular AccidentCOVID crisisCOVID epidemicCOVID pandemicCOVID-19 crisisCOVID-19 epidemicCOVID-19 eraCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 infectionCOVID-19 pandemicCOVID-19 pandemic affectedCOVID-19 pandemic consequenceCOVID-19 pandemic effectsCOVID-19 pandemic impactCOVID-19 pandemic impactedCOVID-19 periodCOVID-19 public health crisisCOVID-19 virus infectionCOVID-19 yearsCOVID19 infectionCardiomyopathiesCase SeriesCase StudyCase-Base StudiesCase-Comparison StudiesCase-Compeer StudiesCase-Referent StudiesCase-Referrent StudiesCase/Control StudiesCausalityCell BodyCellsCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCessation of lifeCetacortChildhoodChronicChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureClinicalCodonCodon NucleotidesCohort StudiesCommentCommentaryComplicationConcurrent StudiesCort-DomeCortefCortenemaCorticosteroneCortisolCortisprayCortrilCorynebacteriumCross Sectional AnalysisCross-Sectional AnalysesCross-Sectional StudiesCross-Sectional SurveyDNA mutationDataData BasesData SetDatabasesDeathDeep Vein ThrombosisDeep-Venous ThrombosisDermacortDiabetic Foot UlcerDiseaseDisease Frequency SurveysDisorderEditorial CommentEducational AchievementEducational StatusEldecortElectronic Health RecordEmotional well beingEmploymentErythrocyte CytoskeletonErythrocyte MembraneEtiologyExclusionExertionFearFeels wellFerritinFrequenciesFrightGene variantGenesGeneticGenetic ChangeGenetic defectGenetic mutationGenetic studyGenomic approachGenomicsGenotypeGenus staphylococcusGoalsGuidelinesHairHb SS diseaseHbASHbSS diseaseHealthHealth Care UtilizationHealth behaviorHeart failureHeightHemoglobin SHemoglobin S DiseaseHemoglobin sickle cell diseaseHemoglobin sickle cell disorderHemolysisHemolytic AnemiaHeterozygoteHistoryHospital AdmissionHospitalizationHydrocortisoneHydrocortoneHytoneImpairmentIn VitroIncidenceIndividualInstitutionInternal MedicineJointsLaboratoriesLegLeg UlcerLogistic RegressionsLower Extremity UlcerMarital StatusMedicalMental HealthMental HygieneMutationMyocardial DiseasesMyocardial DisorderMyocardiopathiesNatureNormal mental conditionNormal mental stateNormal psycheNutracortOrganOutcomePainPainfulParticipantPatient Self-ReportPatientsPhenotypePhysical environmentPhysiologicPhysiologicalPoint MutationPopulationPredispositionPrevalence StudyProceduresProcessProctocortProteinuriaPsychological HealthPsychological Well BeingPublic PolicyPublished CommentPublishingPulmonary EmbolismQOLQuality of Life AssessmentQuality of lifeRandom AllocationRandom SelectionRandomizedRecording of previous eventsRecurrenceRecurrentReportingResearchResearch ResourcesResistanceResourcesRhabdomyolysisRiskRoleSARS-CoV-2 epidemicSARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 infectionSARS-CoV-2 pandemicSARS-CoV2 infectionSARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicSamplingSelf-ReportSense of well-beingSerumSevere Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 pandemicSeveritiesSeverity of illnessShapesSickle CellSickle Cell AnemiaSickle Cell TraitSickle HemoglobinSierra LeoneSleep disturbancesSocial EnvironmentSocial FunctioningSocial SciencesStaphylococcusStressStrokeSurvey InstrumentSurveysSusceptibilitySymptomsTestingThromboembolismTimeTransfusionUlcerUlcerationUnited StatesVaccine ResearchVariantVariationViewpointWeightWell in selfaberrant sleepadulthoodallelic variantanaerobebacteria pathogenbacterial pathogenbehavioral healthbeta Globinbio-markersbiologic markerbiomarkerbrain attackcardiac failurecarrier detectioncarrier screeningcarrier statuscarrier testingcase reportcase-controlled studiescausationcerebral vascular accidentcerebrovascular accidentchronic kidney diseaseclinical careco-morbidco-morbiditycohortcommunity microbescomorbiditycoronavirus disease 2019 crisiscoronavirus disease 2019 epidemiccoronavirus disease 2019 global health crisiscoronavirus disease 2019 global pandemiccoronavirus disease 2019 health crisiscoronavirus disease 2019 infectioncoronavirus disease 2019 pandemiccoronavirus disease 2019 pandemic consequencecoronavirus disease 2019 pandemic impactcoronavirus disease 2019 public health crisiscoronavirus disease crisiscoronavirus disease epidemiccoronavirus disease pandemiccoronavirus disease-19 global pandemiccoronavirus disease-19 pandemiccurrent pandemiccutaneous microbiomedata basedermal microbiomedesigndesigningdiabetic foot wounddisease causationdisease severitydisrupted sleepdisturbed sleepeditorialeducational leveleffects following the COVID-19 pandemicelectronic health care recordelectronic health medical recordelectronic health plan recordelectronic health registryelectronic medical health recordemotional distressemotional wellbeingemotional wellnessentire genomeepidermal microbiomeerythrolysisfeeling distressfeeling upsetfull genomefunction sociallyfunctioning socialgenetic variantgenome mutationgenome sequencinggenomic effortgenomic strategygenomic varianthealinghealth assessmenthealth care qualityhealth care servicehealth care service usehealth care service utilizationhealth related behaviorheterozygosityhistoriesimpact of the SARS-CoV-2 pandemicimpaired sleepimprovedinclusion criteriainfected with COVID-19infected with COVID19infected with SARS-CoV-2infected with SARS-CoV2infected with coronavirus disease 2019infected with severe acute respiratory syndrome coronavirus 2insightinterestirregular sleepmeeting abstractsmental well-beingmental wellbeingmental wellnessmicrobe communitymicrobial communitymicrobial signaturemicrobiomemicroorganism communitymyocardium diseasemyocardium disordernon-English languagenonEnglish languageoffspringopportunistic pathogenpandemicpandemic diseasepathogenic bacteriapatient populationpediatricperceived stressperception of stressphysical conditioningphysical healthpolymicrobial communityprematureprematuritypresent pandemicprogramspsychologicpsychologicalpsychological wellbeingpsychological wellnesspsychosocialpsychosocial well-beingpsychosocial wellbeingpsychosocial wellnessrandomisationrandomizationrandomly assignedrecruitresearch studyresilienceresilientresistantscreening programself wellnessself-reported stresssense of wellbeingsevere acute respiratory syndrome coronavirus 2 global health crisissevere acute respiratory syndrome coronavirus 2 global pandemicsickle RBCsickle cell diseasesickle cell disordersickle diseasesickle erythrocytesickle red blood cellsicklemiaskin biomeskin microbiomesleep disruptionsleep dysregulationsleep/wake disruptionsleep/wake disturbancesocialsocial climatesocial contextsocial rolesocioenvironmentsocioenvironmentalstress perceptionstrokedstrokessystematic reviewtraining achievementtraining leveltraining statusvaccine-related researchweightswhole genomework groupworking groupβ-globin
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GOAL: SYSTEMATIC REVIEW OF CLINICAL COMPLICATIONS OF SICKLE CELL TRAIT (SCT)
For Aim 1: A systematic review of published original research articles between January 1970 and June 30, 2018, that reported an association between SCT and clinical outcomes of interest were reviewed by an expert working group. We followed standard procedures for…
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