grant
Insights into Cognitive Resilience: Sleep, Physical Activity, and Neuroimaging Biomarkers in Aging and Preclinical Alzheimer's Disease
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 15 Jun 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2025AD dementiaAD pathologyAD related dementiaADRDAddressAgeAgingAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease pathologyAlzheimer's disease related dementiaAlzheimer's pathologyAlzheimers DementiaAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAreaAβAβ burdenBiological MarkersBloodBlood Reticuloendothelial SystemBrainBrain Nervous SystemCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCareer MobilityCerebrospinal FluidClinicalCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive agingCognitive declineCognitive function abnormalDWI (diffusion weighted imaging)DWI-MRIDataDevelopmentDevelopment PlansDiffusionDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDiseaseDisorderDisturbance in cognitionEarly InterventionEncephalonEnrollmentFosteringFunctional MRIFunctional Magnetic Resonance ImagingFutureGoalsImpaired cognitionIndividualIndividual DifferencesInterventionIntervention StrategiesInvestigationInvestigatorsK-AwardsK-Series Research Career ProgramsK23 AwardK23 MechanismK23 ProgramKnowledgeLife StyleLifestyleLinkLongitudinal StudiesMR ImagingMR TomographyMRIMRIsMT-bound tauMagnetic Resonance ImagingMaintenanceMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMentored Patient-Oriented Research Career Development AwardMentored Patient-Oriented Research Career Development Award (K23)MentorsMentorshipMethodsNMR ImagingNMR TomographyNeurocognitiveNuclear Magnetic Resonance ImagingOlder PopulationPETPET ScanPET imagingPETSCANPETTPathologicPathologyPatient Self-ReportPhysical activityPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrimary Senile Degenerative DementiaProspective StudiesPublishingRad.-PETResearchResearch Career ProgramResearch PersonnelResearch TrainingResearchersRestRoleSample SizeSelf-ReportSleepStatistical Data AnalysesStatistical Data AnalysisStatistical Data InterpretationStructureTestingTimeTrainingWorkWristZeugmatographya beta peptidea-beta burdenabetaabeta burdenactigraphactigraphyage associatedage associated alterationsage associated changesage correlatedage correlated alterationsage correlated changesage dependentage dependent alterationsage dependent changesage induced alterationsage induced changesage linkedage relatedage related alterationsage related changesage specificage specific alterationsage specific changesaged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsagesaging associated alterationsaging associated changesaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging populationaging related alterationsaging related changesaging resilienceaging specific alterationsaging specific changesalterations with ageamyloid betaamyloid burdenamyloid-b proteinbeta amyloid burdenbeta amyloid fibrilbio-markersbiologic markerbiomarkerbrain healthcareer advancementcareer developmentcareer transitioncerebral spinal fluidchanges with ageclassroom environmentcognitive assessmentcognitive dysfunctioncognitive enhancementcognitive losscognitive performancecognitive testingcollege atmospherecollegial atmospherecollegiate atmospheredMRIdementia riskdesigndesigningdevelopmentaldiffuseddiffusesdiffusingdiffusion tensor imagingdiffusionseducation atmosphereeducational atmosphereeducational environmentenrollexperiencefMRIindexinginsightintellectual atmosphereinvestigator traininglearning atmospherelearning environmentlong-term studylongitudinal outcome studiesmicrotubule bound taumicrotubule-bound taumid lifemid-lifemiddle agemiddle agedmidlifemodifiable lifestyle factorsmultidisciplinaryneural imagingneuro-imagingneuroimagingneuroimaging biomarkerneuroimaging markerneurological imagingnovelolder adultolder adulthoodolder groupsolder individualsolder personpopulation agingpositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypre-clinicalpreclinicalprimary degenerative dementiaprogramsquality of sleeprate of changeresearch on resilienceresearch on resiliencyresearch studyresilienceresilience during agingresilience in agingresilience in normal agingresilience researchresilience to agingresilience with agingresiliency researchresilientresilient agingresilient to agingresponsible research conductrisk factor for dementiarisk for dementiaschool atmosphereschool climatesenile dementia of the Alzheimer typeskillssleep amountsleep durationsleep episodesleep intervalsleep lengthsleep periodsleep qualitysleep quantitysleep timesocial rolesoluble amyloid precursor proteinspinal fluidstatistical analysistautau Proteinstau factortime asleeptime during sleeptime in sleeptime spent asleeptime spent sleepingtraining atmosphereuniversity atmosphereβ-amyloid burdenβamyloid burdenτ Proteins
Description preview
This Mentored Patient-Oriented Research Career Development Award (K01) application aims to equip the
candidate with the skills to establish an independent research program identifying modifiable lifestyle factors to
enhance cognitive resilience in aging and Alzheimer's disease-related dementias (ADRDs) and develop
neuroimaging measures to quantify…
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