grant
Innate immunity and ischemic stroke
Organization VETERANS HEALTH ADMINISTRATIONLocation PITTSBURGH, UNITED STATESPosted 1 Oct 2024Deadline 30 Sept 2028
VANIHUS FederalResearch GrantFY202621+ years oldAcquired brain injuryAdenosineAdultAdult HumanAgonistAnimal ModelAnimal Models and Related StudiesAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntithrombotic AgentsAntithrombotic DrugsApoplexyAttenuatedBehavioralBioinformaticsBrainBrain InjuriesBrain IschemiaBrain Nervous SystemBrain Vascular AccidentCause of DeathCell Communication and SignalingCell SignalingCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeClinicalCytoplasmDNA Transposable ElementsDNA mutationDataDevelopmentDideoxy Chain Termination DNA SequencingDoseDysfunctionEncephalonEnzyme GeneEnzymesEvolutionFibrinolytic AgentsFibrinolytic DrugsFoundationsFunctional disorderGenderGene ExpressionGenesGenetic ChangeGenetic defectGenetic mutationIFNIFN activationImmune Cell ActivationImmune systemImmunomodulationInfarctionInflammationInflammatoryInnate ImmunityInosineInterferon ActivationInterferonsIntracellular Communication and SignalingIschemiaIschemic Brain InjuryIschemic EncephalopathyIschemic StrokeJumping GenesLinkMeasuresMechanicsMediatingMiceMice MammalsMiddle Cerebral Artery OcclusionModalityModelingMolecularMurineMusMutationNative ImmunityNatural ImmunityNervous System DiseasesNervous System DisorderNervous System PhysiologyNeurologic DisordersNeurologic functionNeurological DisordersNeurological functionNon-Polyadenylated RNANon-Specific ImmunityNonspecific ImmunityPathogenesisPhysiopathologyPlayPost-Transcriptional RNA ModificationPost-Transcriptional RNA ProcessingProductionRNARNA EditingRNA Gene ProductsRNA SeqRNA SequencesRNA sequencingRNA, Messenger, EditingRNAseqReactionResearchRibonucleic AcidRoleSanger SequencingSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStaining methodStainsStrokeTestingThrombectomyThrombolytic AgentsThrombolytic DrugsTimeTranscriptTranslatingTransposable ElementsUnited Statesadenosine deaminase that acts on RNAadulthoodage associatedage correlatedage dependentage linkedage relatedage specificagedaged miceaged mouseantithrombotic medicationantithromboticsattenuateattenuatesbehavior outcomebehavioral outcomebiological signal transductionbrain attackbrain damagebrain tissuebrain-injuredcerebral ischemic damagecerebral ischemic injurycerebral vascular accidentcerebrovascular accidentcytokinedADARdevelopmentaldisabilitydouble-stranded RNA-specific adenosine deaminasedsRNA adenosine deaminasedsRNA-specific adenosine deaminaseelderly micegenome mutationimmune activationimmune modulationimmune regulationimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryinfarctinnate immune pathwaysinsightischemic brain damageloss of function mutationmechanicmechanicalmobile DNAmodel of animalnervous system functionneural inflammationneuroinflammationneuroinflammatoryneurological diseasenew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetold miceoverexpressoverexpressionpathophysiologypreventpreventingresponsesocial rolestroke therapystroke treatmentstrokedstrokestargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttissue repairtranscriptome sequencingtranscriptomic sequencingtranslational opportunitiestranslational potentialtransposon/insertion elementtreating stroke
Description preview
Abstract
The immune system is closely involved in all stages of ischemic stroke-induced brain damage
and tissue repair. However, treatments aimed at modulating inflammation have not been
successfully translated into the clinical settings yet. Therefore, the development of new anti‐
inflammatory therapies, especially those targeting upstream…
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