grant
Initiation of DNA Replication in Mammalian Cells
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY20253-D3-Dimensional3D53BP1AffectAgingArchitectureAssayBindingBinding ProteinsBioassayBiochemicalBioinformaticsBiological AssayCancersCell BodyCell Communication and SignalingCell CycleCell Division CycleCell Growth in NumberCell MultiplicationCell ProliferationCell SignalingCellsCellular ExpansionCellular GrowthCellular ProliferationChromatinChromatin StructureChromosomesChronologyClinicalCollaborationsCommunicationComplexDNADNA DamageDNA Damage RepairDNA HelicasesDNA InjuryDNA RepairDNA Repair PathwayDNA ReplicationDNA Replication InitiationDNA SynthesisDNA Unwinding ProteinsDNA biosynthesisDNA fiber analysisDNA fiber approachDNA fiber assayDNA fiber combingDNA fiber methodDNA fiber spreadingDNA fiber techniqueDNA unwinding enzymeDeacetylaseDeoxyribonucleic AcidDevelopmental TherapeuticsDevelopmental Therapeutics ProgramDevelopmental TherapyEngineering / ArchitectureEventExhibitsGene TranscriptionGenetic TranscriptionGenomeHumanImageIntracellular Communication and SignalingInvestigatorsKinasesKnowledgeLigand Binding ProteinLigand Binding Protein GeneLocationMaintenanceMalignant CellMalignant NeoplasmsMalignant TumorMammalian CellMapsMediatingMediatorMetabolicModern ManMolecularMolecular InteractionMutateNaturePathway interactionsPatternPhosphorylationPhosphotransferase GenePhosphotransferasesPre-Replication ComplexPredispositionPrevalencePreventionProliferatingProtein BindingProtein PhosphorylationProteinsRNA ExpressionRecoveryRegulationRegulatory PathwayReplication InitiationReplication OriginReplication ProcessReplication-Associated ProcessReportingResearchResearch PersonnelResearchersSIRT1SIRT1 geneSeriesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSirtuin 1SiteSusceptibilitySyndromeTP53BP1Therapeutic InterventionTranscriptionTranslatingTransphosphorylasesUbiquitin Ligase Component GeneUbiquitin Ligase GeneUnscheduled DNA Synthesisaging associatedaging processaging relatedbiological signal transductionbound proteincancer cellcell growthchemotherapeutic agentchemotherapeutic compoundschemotherapeutic drugschemotherapeutic medicationschromatin modificationchromatin proteincohesinentire genomeextrachromosomal DNAfull genomegene locusgenetic locusgenome scalegenome-widegenomewidegenomic locationgenomic locushelicaseimagingintervention therapymalignancyneoplasm/cancernovelori Regionp202p53-binding protein 1p53BP1pathwaypre-RCpreventpreventingprogramsprotein complexrecruitreplication stressresponsetherapeutic targetthree dimensionalubiquitin ligasewhole genome
Description preview
Our studies focus on cellular signaling pathways that regulate cell proliferation, focusing on the location, timing and progression of DNA synthesis in cancer cells. Since many regulatory pathways that affect chromosome duplication are deregulated in cancer, our findings can facilitate understanding the regulation of cancer cell proliferation and…
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