grant
Inhibition of Radiation-Induced Salivary Gland Fibrosis by Targeting Copper Metabolism
Organization UNIVERSITY OF MISSOURI-COLUMBIALocation COLUMBIA, UNITED STATESPosted 1 Aug 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2026AQP1 geneAffectAgonistAmerican Cancer SocietyAsialiaAutoregulationBinding SitesBiomedical EngineeringBody TissuesBuccal MucosaC10Cancer CauseCancer EtiologyCatalytic CoreCatalytic DomainCatalytic RegionCatalytic SiteCatalytic SubunitCell BodyCell membraneCell-Extracellular MatrixCellsChelating AgentsChelatorsChronicClinicalClinical Treatment MoabClinical TrialsCollagenCollagen Lysyl OxidaseCombining SiteCommon Rat StrainsComplexonsComputersConnective TissueCopperCu elementCytoplasmic MembraneDNA TherapyDepositDepositionDiseaseDisorderDrug DesignEC 1.4.3.13ECMEnzyme GeneEnzymesEventExtracellular MatrixEyeEyeballFamilyFamily memberFibrosing AlveolitisFibrosisGene InactivationGene SilencingGene Transfer ClinicalGenetic InterventionGenetic studyGolgiGolgi ApparatusGolgi ComplexHead and Neck CancerHead and Neck CarcinomaHeartHomeostasisHyposalivationIn VitroIndividualInjectionsIntermediary MetabolismIonizing Electromagnetic RadiationIonizing radiationKidneyKidney Urinary SystemLiverLiver FibrosisLungLung Respiratory SystemLysyl OxidaseMalignant CellMalignant Head and Neck NeoplasmMetabolic ProcessesMetabolismMiceMice MammalsMolecularMonoclonal AntibodiesMouth DrynessMouth MucosaMurineMusNuclearOralOral MucosaOral healthOral mucous membrane structureOrganParotidParotid GlandPathologicPatientsPersonsPhase 2 Clinical TrialsPhase II Clinical TrialsPhysiological HomeostasisPlasma MembraneProcessProduce salivaProgenitor Cell TransplantationProtein-Lysine 6-OxidaseRadiationRadiation FibrosisRadiation therapyRadiation-Ionizing TotalRadiotherapeuticsRadiotherapyRatRats MammalsRattusReactive SiteResidualResidual stateRoleSalivaSaliva productionSalivary Gland TissueSalivary GlandsSalivary excretionSalivary hypofunctionSalivationSkinStem Cell TransplantationStem cell transplantSubmandibular glandSubmaxillary GlandTTM cpdTestingTherapeuticTherapeutic EffectTissuesUnited StatesVesicleXerostomiaXerostomicantifibrotic agentantifibrotic medicationantifibrotic therapyantifibrotic treatmentaptyalismaquaporin 1bio-engineeredbio-engineersbioengineeringbiological engineeringcancer cellclinical applicabilityclinical applicationclinical relevanceclinically relevantcofactorcrosslinkdental healthdiffuse interstitial pulmonary fibrosisdry mouthfibrotic livergene repair therapygene therapygene-based therapygenetic therapygenomic therapyhead/neck cancerhepatic body systemhepatic fibrosishepatic organ systemidiopathic pulmonary fibrosisin vivoin vivo Modelinhibitorionizing outputmAbsmalignant head and neck tumormembermetalloenzymemonoclonal Absmouse modelmurine modelnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachoral drynessoral mucosaeoral mucosalpharmacologicphase II protocolplasmalemmaprimary sclerosing cholangitisprogenitor transplantationradiation induced fibrosisradiation treatmentrenalsaliva secretionsalivary gland hypofunctionsalivary productionsalivary secretionside effectsocial rolestandard carestandard treatmentstem and progenitor cell transplantationstetrathiomolybdatetraffickingtranscriptional silencingtreatment with radiation
Description preview
ABSTRACT
A first-line treatment for head and neck cancer is radiation therapy, but ionizing radiation can lead to chronic oral
complications such as fibrosis of the salivary glands (SG) and xerostomia. Therapeutic strategies to restore SG
function include gene therapy, stem cell transplantation and various bioengineering approaches; however, they…
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