grant
Inhibition of Abeta42 aggregation by helix stabilizing peptidomimetic biomaterials
Organization UNIVERSITY OF SOUTH FLORIDALocation TAMPA, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025A β-42A β42A-beta 42A-beta42AD dementiaAD transgenic miceAbeta-42Abeta42AbscissionAducanumabAdverse effectsAffinityAgreementAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's biomarkerAlzheimer's diagnosisAlzheimer's disease biological markerAlzheimer's disease diagnosisAlzheimer's disease riskAlzheimer's disease transgenic miceAlzheimer's transgenic miceAlzheimers DementiaAlzheimer’s biological markerAlzheimer’s disease biomarkerAmentiaAmyloidAmyloid (Aβ) plaquesAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid PlaquesAmyloid Protein A4Amyloid ProteinsAmyloid SubstanceAmyloid beta-42Amyloid beta-ProteinAmyloid beta42Amyloid βAmyloid β oligomerAmyloid β-42Amyloid β-PeptideAmyloid β-ProteinAmyloid β42AmyloidosisAmyloidβ-42Amyloidβ42AssayAstrocytesAstrocytusAstrogliaAβAβ-42Aβ42AβOBIIB037Behavioral AssayBeta SheetBindingBioassayBiocompatible MaterialsBiological AssayBiomaterialsBrainBrain Nervous SystemCausalityCell BodyCell SurvivalCell ViabilityCellsCellular ExpansionCellular GrowthCellular StressCellular Stress ResponseChemicalsClinical Treatment MoabDLG4DLG4 geneDementiaDepositDepositionDevelopmentDiabetes MellitusDiseaseDisorderEncephalonEnzyme AntagonistEnzyme InhibitorEnzyme Inhibitor AgentEnzyme Inhibitor DrugsEquilibriumEsteroproteasesEtiologyExcisionExtirpationFDA approvedGeneralized GrowthGoalsGrowthHortega cellHuntington ChoreaHuntington DiseaseHuntington'sHuntington's DiseaseHuntingtons DiseaseHybridsImmunoblottingIn VitroInflammationInsulinoma amyloid peptideInterventionKineticsLeadLigand BindingMT-bound tauMemoryMemory DeficitMemory impairmentMiceMice MammalsMicrogliaMitochondriaMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular ProbesMolecular StereochemistryMolecular WeightMonoclonal AntibodiesMurineMusNAC precursorNatureNerve CellsNerve UnitNeural CellNeuritic PlaquesNeurocyteNeuronsOutcomePARK1 proteinPARK4 proteinPSD95Paralysis AgitansParkinsonParkinson DiseasePathogenesisPathogenicityPathologyPathway interactionsPatternPb elementPeptidasesPeptide HydrolasesPeptide LibraryPeptide-based drugPeptidesPerformancePhagocytosisPhysiologicPhysiologicalPlayPredispositionPreventionPrimary ParkinsonismPrimary Senile Degenerative DementiaProcessProductionProtease GeneProteasesProteinasesProteolytic EnzymesRemovalResearchRoleSAP90SNCASNCA proteinSenile PlaquesSideSignal PathwayStructureSurfaceSurgical RemovalSusceptibilitySynaptic Vesicle P38 Membrane ProteinSynaptic Vesicle Protein P38SynaptophysinTestingTherapeuticTherapeutic AgentsTherapeutic antibodiesTissue GrowthToxic effectToxicitiesWestern BlottingWestern ImmunoblottingWorka beta peptidea-syna-synucleinabetaabeta accumulationabeta aggregationabeta oligomeraduhelmalpha synucleinalpha synuclein genealphaSP22alzheimer riskamlintideamylinamyloid betaamyloid beta accumulationamyloid beta aggregationamyloid beta oligomeramyloid beta plaqueamyloid diseaseamyloid pathologyamyloid β accumulationamyloid β aggregationamyloid-b plaqueamyloid-b proteinanalogastrocytic gliaasynaβ accumulationaβ aggregationaβ oligomeraβ plaquesbalancebalance functionbeta amyloid fibrilbeta pleated sheetbiological materialcausationcell growthcell stressconformationconformationalconformational stateconformationallyconformationscored plaquecostdesigndesigningdevelopmentaldiabetesdiabetes associated peptidediffuse plaquedisease causationdisease preventiondisorder preventionfunctional groupgitter cellheavy metal Pbheavy metal leadimprovedin vitro Assayin vivoinnovateinnovationinnovativeinsightinsoluble aggregateinsulinoma amyloid polypeptideislet amyloid polypeptidemAbsmemory dysfunctionmesogliamicroglial cellmicrogliocytemicrotubule bound taumicrotubule-bound taumimeticsmitochondrialmonoclonal Absmonomermouse modelmurine modelneurodegenerative dementianeuron toxicityneuronalneuronal survivalneuronal toxicityneurotoxicneurotoxicitynon A-beta component of AD amyloidnon A4 component of amyloid precursornoveloAβoligomeric amyloid betaoligomeric amyloid-βontogenypancreatic amylinpathwaypeptide drugpeptide mimeticpeptide mimicpeptidomimeticsperivascular glial cellpreventpreventingprimary degenerative dementiaprotein aggregateprotein aggregationprotein blottingrational designresectionsenile dementia of the Alzheimer typeside effectsocial rolesoluble amyloid precursor proteinsystemic inflammationsystemic inflammatory responsetautau Proteinstau factortherapeutic peptideα synuclein geneα-synα-synucleinβ-Sheetβ-pleated sheetτ Proteins
Description preview
Alzheimer’s disease (AD) is the most devastating dementia of global concern. Although the mechanism of AD
pathogenesis is still under debate, it is agreed that Aβ aggregation are prominent hallmarks and the major risk
of AD due to their toxicity to neurons. Therefore, Aβ aggregates, particularly oligomers, are the potential targets
for the…
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