grant
Inhibiting CNS resident memory T cells driving neuroinflammation
Organization BENAROYA RESEARCH INST AT VIRGINIA MASONLocation SEATTLE, UNITED STATESPosted 20 Feb 2026Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026AffectAllelesAllelomorphsAnimal ModelAnimal Models and Related StudiesAutoimmuneAutoimmune DiseasesAutoimmune ResponsesAutomobile DrivingAxonB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBioinformaticsBiopsyBloodBlood Reticuloendothelial SystemBody TissuesCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCNS DiseasesCNS Nervous SystemCNS autoimmunityCNS disorderCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas9 screenCell Growth and MaintenanceCell MaintenanceCentral Nervous SystemCentral Nervous System DiseasesCentral Nervous System DisordersChronicCuesDemyelinationsDevelopmentDiseaseDisease ProgressionDisorderDisseminated SclerosisEAEExperimental Allergic EncephalitisExperimental Allergic EncephalomyelitisExperimental Autoimmune EncephalitisExperimental Autoimmune EncephalomyelitisExperimental ModelsGenesHealthHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteIndividualInducer CellsInducer T-LymphocytesInflammatory ResponseInstitutionLymphatic TissueLymphoid TissueMS patientMS treatmentMaintenanceMediatingMolecularMultiple SclerosisNerve TissueNervous TissueNeuraxisPathogenesisPathway interactionsPhenotypePlayPositionPositioning AttributePredispositionRelapseReportingResearchRoleSamplingSignal PathwaySusceptibilityT memory cellT-CellsT-LymphocyteT4 CellsT4 LymphocytesTestingTimeTissue ModelTissuesWorkautoimmune conditionautoimmune disorderautoimmune encephalomyelitisautoimmunity diseaseautoreactive T cellcentral nervous system autoimmunityclustered regularly interspaced short palindromic repeats screendemyelinatedevelopmentaldifferential expressiondifferentially expresseddisabilitydrivingexperiencegene signaturesgenetic signatureimprovedinsular sclerosismemory CD4 T cellmemory CD4 T lymphocytememory T lymphocytemigrationmodel of animalmultiple sclerosis patientmultiple sclerosis therapymultiple sclerosis treatmentneural inflammationneuroinflammationneuroinflammatorynovelpathwaypatients with MSpatients with multiple sclerosispeople with Multiple sclerosisresident memory T cellself-reactive T cellsocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthymus derived lymphocytetissue resident memory T celltooltranscriptional differences
Description preview
Project Summary
Multiple sclerosis (MS) is a chronic, autoimmune-mediated disease of the central nervous system characterized
by demyelination, axonal loss, and progressive disability. Experimental autoimmune encephalomyelitis (EAE) is
an animal model which shares specific particularities with MS, has helped develop current disease modifying…
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