grant
Influence of neuromelanin on single dopaminergic neurons in Parkinson's disease.
Organization OKLAHOMA MEDICAL RESEARCH FOUNDATIONLocation OKLAHOMA CITY, UNITED STATESPosted 1 Feb 2025Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY2026Adeno-Associated VirusesAgeAnatomic SitesAnatomic structuresAnatomyAnimal ModelAnimal Models and Related StudiesAssayAstrocytesAstrocytusAstrogliaAutopsyBehaviorBehavioralBilateralBioassayBiological AssayBiological FunctionBiological ProcessBrainBrain Nervous SystemBrain regionCalciumCell BodyCell DeathCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessCommon Rat StrainsCommunicationCorpus StriatumCorpus striatum structureCresolaseD2 receptorDA NeuronDAT dopamine transporterDRD2 ReceptorDarknessDataData SetDegenerative Neurologic DisordersDependoparvovirusDependovirusDevelopmentDiathesisDiseaseDisease ProgressionDisease susceptibilityDisorderDopa OxidaseDopamine D2 ReceptorDopamine neuronElectrophysiologyElectrophysiology (science)EncephalonEnzyme GeneEnzymesExhibitsExposure toFemaleFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFutureGaitGene AlterationGene MutationGenesGeneticGenetic studyHortega cellHumanHuman GeneticsImpairmentInflammationInflammatoryInjectionsIntervention StudiesIon ChannelIonic ChannelsK elementKnowledgeLocomotionMeasuresMediatingMelaninsMembrane ChannelsMesencephalonMethodsMiceMice MammalsMicrogliaMid-brainMidbrainMidbrain structureModelingModern ManMonophenol MonooxygenaseMorphologyMurineMusNerve CellsNerve DegenerationNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeuritesNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationNeuronsNeurophysiology / ElectrophysiologyOxidantsOxidizing AgentsPace StimulatorsPacemakersParalysis AgitansParkinsonParkinson DiseasePathogenesisPathologyPatientsPatternPhenocopyPhenol OxidasePhenoloxidasePhenotypePhysiologicPhysiologicalPigmentsPopulationPotassiumPreclinical dataPredispositionPrimary ParkinsonismProceduresProcessRatRats MammalsRattusResearchRisk FactorsRodentRodent ModelRodentiaRodents MammalsRoleStriate BodyStriatumSubcellular ProcessSubstantia NigraSubstantia nigra structureSusceptibilitySymptomsTechniquesTestingTherapeutic AgentsTimeToxinTranslatingTyrosinaseVentral Tegmental AreaViralVirusadeno associated virus groupagesastrocytic gliabrain cellcell preparationcell typedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdesigndesigningdevelopmentaldisease modeldisorder modeldopamine transporterdopaminergic neuronelectron acceptorelectrophysiologicalexperienceexperimentexperimental researchexperimental studyexperimentsflow cytophotometrygene defectgitter cellintervention researchinterventional researchinterventional studyinterventions researchjuvenile animalliability to diseasemalemesogliamicroglial cellmicrogliocytemid lifemid-lifemiddle agemiddle agedmidlifemodel of animalmolecular phenotypemonophenol oxidasemotor deficitmotor impairmentmotor symptommouse modelmovement impairmentmovement limitationmurine modelmutant allelenecrocytosisnecropsynerve cell deathnerve cell lossneural degenerationneural inflammationneurodegenerationneurodegenerativeneurodegenerative illnessneuroinflammationneuroinflammatoryneurological degenerationneuromelaninneuron cell deathneuron cell lossneuron deathneuron lossneuronalneuronal cell deathneuronal cell lossneuronal deathneuronal degenerationneuronal excitabilityneuronal lossnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetoverexpressoverexpressionpars compactapatch clamppatch sequencingpatch-seqpatchseqperivascular glial cellpigmentpostmortempostsynapticpre-clinicalpre-clinical studypreclinicalpreclinical findingspreclinical informationpreclinical studyscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestriatalsymptom treatmentsymptomatic treatmenttransduction efficiencytreat symptomventral tegmentumyoung animal♀♂
Description preview
Dopamine neurons in the substantia nigra pars compacta (SNc) are exquisitely susceptible to degeneration
and are responsible for the cardinal motor symptoms of Parkinson’s disease (PD). All currently available
treatments for PD such as L-DOPA focus on symptoms, and none of the promising results from preclinical
studies have translated to a single…
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