grant
Influence of Maternal IgA on Neonatal iNKT Cell Development and Gluten Sensitive Enteropathy.
Organization UNIVERSITY OF SOUTH CAROLINA AT COLUMBIALocation COLUMBIA, UNITED STATESPosted 15 May 2025Deadline 14 May 2028
NIHUS FederalResearch GrantFY202516S RNA sequencing16S RNAseq16S gene sequencing16S rDNA amplicon sequencing16S rRNA DNA sequencing16S rRNA amplicon sequencing16S rRNA gene amplicon sequencing16S rRNA gene sequencing16S rRNA genomic profiling16S rRNA sequencing16S ribosomal RNA gene sequencing16S ribosomal RNA sequencing16S seq16S sequencing16s rRNA seq21+ years oldATACAbdominal PainAddressAdultAdult ChildrenAdult DaughtersAdult HumanAdult OffspringAdult SonsAnemiaAnimalsAntigensAtaxiaAtaxyBarleyBionomicsBreast MilkBreastmilkBreedingCD19CD19 geneCeliac DiseaseCeliac SprueCell BodyCellsChronicCoeliac DiseaseComplexComplicationCoordination ImpairmentCorrelative StudyDataDefectDevelopmentDiarrheaDietDiseaseDisorderDyssynergiaEcologyElasticityEnvironmentEnvironmental FactorEnvironmental Risk FactorExposure toFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFoodFosteringGeneticGerm-FreeGlutelinGlutenGluten EnteropathyGluten-Sensitive EnteropathyGluten-free dietHealthHistologicHistologicallyHordeum vulgareHuman MilkHuman Mother's MilkIgAIgA DeficiencyImmuneImmune ToleranceImmune systemImmunesImmunoglobulin AImmunologic ToleranceIndividualInflammationInflammatory Bowel DiseasesInflammatory Bowel DisorderInflammatory ResponseIngestionKnowledgeLPTNLifeMalabsorption SyndromesMammary Gland MilkMaternal antibodyMental DepressionMetabolicMiceMice MammalsMilkModelingMother's MilkMucosal Immune ResponsesMucosal ImmunityMurineMusNeonatalNeurologic EffectNon-tropical SprueNontropical SprueNutrientNutritionalPathogenesisPathologicPatientsPeptidesPhenotypePhysiologicPhysiologicalPopulationPredispositionPrevalencePreventionProductionPropertyRNA SeqRNA sequencingRNAseqRoleRyeRye cerealSCM-1SCM-1aSCM1SCYC1SeriesShapesSmall IntestinesStreptococcusSusceptibilityT-Cell DevelopmentT-Cell OntogenyT-CellsT-LymphocyteT-Lymphocyte DevelopmentTestingTimeVertical TransmissionWeaningWheatXCL1XCL1 geneadulthoodbowel inflammationbrain fogcommensal bacteriacommensal bacterial speciescommensal floracommensal microbescommensal microbiotacommensal microfloradepressiondevelopmentaldietarydietsearly life exposureenvironmental riskexperienceexperimentexperimental researchexperimental studyexperimentsfeedingflow cytophotometryfood antigengastrointestinalgastrointestinal absorption disordergut homeostasisgut inflammationhigh riskidiopathic steatorrheaimmune system toleranceimmune unresponsivenessimmunogenimmunogenicimmunoglobulin A deficiencyimmunological paralysisinflamed bowelinflamed gutinflamed intestineinflammatory disease of the intestineinflammatory disorder of the intestineingestintestinal autoinflammationintestinal inflammationintestinal malabsorptionlater in lifelater lifemalabsorptionmaternal floramaternal microbiomematernal microbiotamaternal milkmetatranscriptomicsmicrobialmicrobial colonizationmicrobial consortiamicrobial floramicrobiotamicrobiota compositionmicrofloramouse modelmucosa-associated microbesmucosa-associated microbial communitymucosa-associated microbiotamucosal floramucosal microbesmucosal microbiotamucosal microfloramultispecies consortiamurine modelneonatal exposureneonatal periodneonatenew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targetnutritiousoffspringpathobiontpostnatalpregnantprenatalpreventpreventingprogramsprotein complexpupresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsmall bowelsocial rolethymus derived lymphocytetranscriptome sequencingtranscriptomic sequencingunborn
Description preview
PROJECT SUMMARY______________________________________________________________________
Early maternal-offspring interactions, such as the transfer of IgA through breast milk, are key in shaping mucosal
immunity and microbiota composition. Correlative studies suggest that individuals who were formula-fed are at
a higher risk of gluten sensitivities,…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click