grant
Inflammatory Signaling in the Leptomeninges
Organization SLOAN-KETTERING INST CAN RESEARCHLocation NEW YORK, UNITED STATESPosted 11 Mar 2025Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY2026AccelerationAcute-Phase ProteinsAcute-Phase ReactantsAssayBioassayBiochemicalBiological AssayBlocking AntibodiesBody TissuesBrainBrain Nervous SystemCDw128bCMKAR2CNS Nervous SystemCRISPR interferenceCRISPR-dCas9-mediated repressionCRISPR/dCas9 interferenceCRISPR/dCas9-mediated transcriptional inhibitionCRISPRiCXCL1CXCL1 geneCXCR2Cancer Cell GrowthCancer ControlCancer Control ScienceCancersCell Communication and SignalingCell SignalingCentral Nervous SystemCephalicCerebrospinal FluidCerebrospinal Fluid ProteinsCessation of lifeCharacteristicsChemical FractionationClinicalClinical TrialsClustered Regularly Interspaced Short Palindromic Repeats interferenceCo-cultureCocultivationCocultureCoculture TechniquesCollectionColorComplicationCranialDataDeathDissectionDropsDysfunctionEncephalonEnvironmentFRACNFeedbackFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFractionationFractionation RadiotherapyFunctional disorderGRO1GROAGeneralized GrowthGenerationsGenesGrowthH+ elementHumanHydrogen IonsIL8R2IL8RBIL8RB geneImmune systemImmunocompetentImmunofluorescenceImmunofluorescence ImmunologicIn VitroInflammationInflammatoryInflammatory ResponseInterruptionIntracellular Communication and SignalingInvadedKnock-outKnockoutLaboratory StudyLeptomeningeal MetastasisLeptomeningesLeucocytic infiltrateMGSAMalignant CellMalignant NeoplasmsMalignant TumorMedulla SpinalisMeningeal CarcinomatosisMeningitisMetastasis to the LeptomeningesMetastatic Neoplasm to the LeptomeningesMetastatic Tumor to the LeptomeningesModern ManMolecularNeuraxisNeurological disabilityPatientsPhysiopathologyPopulationPre-Clinical ModelPreclinical ModelsPrevalenceProteomicsProtonsRadiation therapyRadiotherapeuticsRadiotherapyRecombinant ProteinsSCYB1SamplingSecondary toSignal TransductionSignal Transduction SystemsSignalingSolid NeoplasmSolid TumorSourceSpinal CordSystemTechniquesTissue GrowthTissuesbiological signal transductioncancer cellcancer complicationcerebral spinal fluidclinical relevanceclinically relevantcytokineflow cytophotometryhuman diseaseimmune competentin vivoinhibitorinnovateinnovationinnovativeirradiationirritationmalignancymeningeal metastasesmouse modelmurine modelneoplasm/cancerneoplastic meningitisontogenyoverexpressoverexpressionpathophysiologypharmacologicpre-clinicalpreclinicalradiation treatmentrepressing CRISPR-dCas9 systemresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingspinal fluidtreatment with radiationtumor
Description preview
PROJECT SUMMARY
Leptomeningeal metastasis (LM) or spread of tumors into the spinal fluid-filled spaces that surround the brain
and spinal cord represents an increasingly common, lethal complication of malignancy. A hallmark of LM is the
robust inflammation that accompanies cancer cell growth in this space. Despite this inflammatory response to…
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