grant
Inflammasomes - a driver of sexual dimorphism to glioma therapies
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAffinotoxinsAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntibody SuppressionAntioncogene Protein p53Antitumor ResponseApoptosis-Related Cysteine Protease Caspase 1AquadiolB-Cell DeficiencyBeta Proprotein Interleukin 1Biological Response ModifiersBiomodulatorsBlood granulocytic cellBlood monocyteBrain CancerCASP-1CASP1CASP1 geneCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCaspase-1Caspase-1 GeneCastrationCell BodyCell Communication and SignalingCell SignalingCellsCellular Tumor Antigen P53ChronicClinicalCo-cultureCocultivationCocultureCoculture TechniquesCombined Modality TherapyCytotoxic ChemotherapyCytotoxic TherapyCytotoxic agentCytotoxic drugCytotoxin-Antibody ConjugatesDataDendritic CellsDimenformonDiogynDiogynetsDiseaseDisorderEGF ReceptorEGFREGFRvIIIERBB ProteinEndocrine Gland SecretionEndothelial CellsEpidermal Growth Factor ReceptorEpidermal Growth Factor Receptor KinaseEpidermal Growth Factor Receptor Protein-Tyrosine KinaseEpidermal Growth Factor-Urogastrone ReceptorsEstraceEstradiolEstradiol-17 betaEstradiol-17betaEstraldineEstrogen ReceptorsEvaluationFemaleFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFour Core GenotypesGenesGeneticGliaGlial Cell TumorsGlial CellsGlial NeoplasmGlial TumorGlioblastomaGliomaGoalsGonadal Steroid HormonesGonosomesGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaGranular LeukocytesGranulocytic cellHER1HormonesHortega cellICE ProteaseIL-1 betaIL-1 beta ConvertaseIL-1 beta-Converting EnzymeIL-1 βIL-1-bIL-1BCIL-1b Converting EnzymeIL-1βIL1-BetaIL1-βIL1B ProteinIL1B-ConvertaseIL1BCIL1BCEIL1F2IL1βImmuneImmune MediatorsImmune Mediators/ModulatorsImmune mediated therapyImmune responseImmunesImmunologically Directed TherapyImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunotherapyImmunotoxinsIndividualInflammasomeInflammationInflammation MediatorsInflammatoryInflammatory ResponseInterleukin 1-B Converting EnzymeInterleukin 1-Beta ConvertaseInterleukin 1betaInterleukin-1 Beta Converting EnzymeInterleukin-1 Converting EnzymeInterleukin-1 betaInterleukin-1βIntracellular Communication and SignalingKolliker's reticulumLymphatic cellLymphocyteLymphocyticMacrophageMalignantMalignant - descriptorMalignant Glial NeoplasmMalignant Glial TumorMalignant GliomaMalignant Neuroglial NeoplasmMalignant Neuroglial TumorMalignant Tumor of the BrainMalignant neoplasm of brainMarrow monocyteMediatingMesenchymalMiceMice MammalsMicrogliaMonoclonal Antibody-Toxin ConjugatesMultimodal TherapyMultimodal TreatmentMurineMusMφNeurogliaNeuroglial CellsNeuroglial NeoplasmNeuroglial TumorNigericinNon-neuronal cellNonneuronal cellOncogenesisOncoprotein p53OophorectomyOutcomeOvariectomyOvocyclinOvocylinP53PBMCPathway interactionsPatientsPeripheral Blood Mononuclear CellPhenotypePhosphoprotein P53Phosphoprotein pp53PopulationPreinterleukin 1 BetaPrimary Brain NeoplasmsPrimary Brain TumorsPrognosisProgynonProliferatingProtein TP53ProteinsRadiationRadiation therapyRadiotherapeuticsRadiotherapyReceptor SignalingRegulationRegulator GenesRelapseResistanceRoleSex ChromosomesSex HormonesSex Steroid HormonesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSurgical CastrationT-Cell ActivationT8 CellsT8 LymphocytesTGF-alpha ReceptorTP53TP53 geneTRP53TestingTherapeutic EstradiolTherapeutic HormoneToxin-Antibody ConjugatesToxin-Antibody HybridsTranscriptional Regulatory ElementsTransforming Growth Factor alpha ReceptorTumor CellTumor Protein p53Tumor Protein p53 GeneUrogastrone ReceptorVariantVariationVeiled CellsX Chromosomeactivate T cellsadulthoodanti-tumor immune therapyanti-tumor immunotherapyanti-tumor responsebiological signal transductionc-erbB-1c-erbB-1 Proteincancer microenvironmentcancer progressioncell typecheck point blockadecheckpoint blockadecombination therapycombined modality treatmentcombined treatmentcytokineeffective therapyeffective treatmentepidermal growth factor receptor VIIIerbB-1erbB-1 Proto-Oncogene ProteinerbBlfemale gonadectomyflow cytophotometrygenetic trans acting elementgitter cellglial-derived tumorglioblastoma multiformegonadal steroidsgranulocytehost responsehumoral immunity deficiencyimmune check point blockadeimmune checkpoint blockadeimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedimproved outcomeinflammatory mediatorinsightlymph cellmalemesogliamicroglial cellmicrogliocytemonocytemulti-modal therapymulti-modal treatmentneoplasm immunotherapyneoplasm progressionneoplastic cellneoplastic progressionnerve cementneuroglia neoplasmneuroglia tumornew approachesnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel approachesnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachp53 Antigenp53 Genesp53 Tumor Suppressorpathwayperivascular glial cellpharmacologicprotein complexprotein p53proto-oncogene protein c-erbB-1radiation treatmentregulatory generesistantresponseresponse to therapyresponse to treatmentscRNA sequencingscRNA-seqsexsex dimorphismsex steroidsexual dimorphismsexually dimorphicsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolespongioblastoma multiformesuccesstherapeutic responsetherapeutic targettherapy responsetrans acting elementtreatment responsetreatment responsivenesstreatment with radiationtumortumor immune therapytumor immunotherapytumor microenvironmenttumor progressiontumorigenesis♀♂
Description preview
ABSTRACT
Malignant gliomas remain lethal with available therapies, including immune checkpoint blockade. Tumor cells
and glioma-associated microglia/macrophages (GAMMs) collectively activate inflammatory responses in the
tumor microenvironment (TME), leading to immune suppression, therapy resistance, tumor progression, and
relapse. Hence,…
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