grant
Inflammaging and Diabetic Retinopathy
Organization AUGUSTA UNIVERSITYLocation AUGUSTA, UNITED STATESPosted 1 Sept 2024Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY202521+ years old3-PyridinecarboxamideAdultAdult HumanAutocrine SystemsAutoregulationBlindnessBlood VesselsCell AgingCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SenescenceCell SignalingCellsCellular AgingCellular FunctionCellular PhysiologyCellular ProcessCellular SenescenceCellular StressCellular Stress ResponseChronicComplications of Diabetes MellitusD-GlucoseDataDevelopmentDextroseDiabetes ComplicationsDiabetes MellitusDiabetes-Related ComplicationsDiabetic ComplicationsDiabetic RetinopathyDiabetic mouseDown-RegulationDysfunctionEndothelial CellsEndotheliumEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEquilibriumEventFeedbackFunctional disorderGene Action RegulationGene Expression RegulationGene RegulationGene Regulation ProcessGlucoseGoalsHD1HDACHDAC ProteinsHDAC1HDAC1 geneHDAC6HDAC6 geneHSP-90HSP90Heat-Shock Proteins 90Histone DeacetylaseHistone Deacetylase 1HomeostasisHyperglycemiaIn VitroInflammagingInflammationInflammatoryIntracellular Communication and SignalingKIAA0901KnowledgeLinkLiteratureMediatingMiceMice MammalsMicroRNAsMicrovascular DysfunctionMolecularMolecular AnalysisMurineMusNerve DegenerationNeuron DegenerationNeutrophil InfiltrationNeutrophil RecruitmentNeutrophilic InfiltrateNiacinamideNicotinamideNicotinamidumNicotinic acid amideNicotylamideNucleotidesOn-Line SystemsOnline SystemsOutcomePathogenesisPathogenicityPathologicPathologyPellagra-Preventing FactorPhysiologicPhysiologicalPhysiological HomeostasisPhysiopathologyPreventionProcessPropertyRPD3-Like 1RPD3L1Rat model of diabetesReduced Potassium Dependency 3, Yeast, Homolog-Like 1RegulationReplicative SenescenceReportingResearch DesignRetinaRetinal Blood VesselsRetinal VesselsRoleSIRT1SIRT1 geneSTZSightSignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeSirtuin 1SterilityStimulusStreptozocinStreptozotocinStressStudy TypeSubcellular ProcessSupplementationSystemTestingTherapeuticVisionVitamin B 3Vitamin B3Vitamin PPZanosaradulthoodage-related inflammationaging associated inflammationantagonismantagonistautocrinebalancebalance functionbiological signal transductioncell stresscombatdevelopmentaldiabetesdiabetes mouse modeldiabeticdiabetic patientdiabetic ratdiabetic rat modeldiagnostic toolepigeneticallyexosomeextracellular vesicleshistone deacetylase 6hsp90 Familyhyperglycemicin vivoinflamm-ageinginflamm-aginginflammation associated with aginginnovateinnovationinnovativeinsightmiRNAmicrovascular complicationsmicrovascular diseasemitochondrial dysfunctionneural degenerationneuro-vascularneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationneurovascularnew diagnosticsnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation diagnosticsnext generation therapeuticsnon-diabeticnondiabeticnovelnovel diagnosticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyonline computeroverexpressoverexpressionparacrinepathophysiologyprematureprematuritypreservationpreventpreventingreplicative agingresponseretina blood vessel structureretinal vascular networkretinal vascular structureretinal vasculaturesenescencesenescence and its associated secretory phenotypesenescence associated secretomesenescence associated secretory factorssenescence associated secretory pathwaysenescence associated secretory phenotypesenescence associated secretory programsenescence associated secretory proteinssenescentsenescent associated secretomesenescent associated secretory phenotypesenomorphicsenostaticsmall vessel diseasesocial rolesterilestudy designtoolvascularvascular stressvision lossvisual functionvisual lossweb based
Description preview
PROJECT SUMMARY
Diabetic retinopathy (DR) is a neurovascular complication of diabetes mellitus and the leading cause of blindness
in adults. Prevention of hyperglycemia-induced retinal microvascular dysfunction remains one of the therapeutic
goal to preserve vision in diabetic patients. Recent insights from our group and others have shown that…
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