grant
Infections and the Stability of Transplantation Tolerance
Organization UNIVERSITY OF CHICAGOLocation CHICAGO, UNITED STATESPosted 17 Jul 2012Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026AddressAffinityAlloantigenAnimalsAnti-Rejection TherapyAntigensAvidityBiological MarkersCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCell Communication and SignalingCell SignalingChronicClinicCross ReactionsDown-RegulationDysfunctionExhibitsExposure toFetusFunctional disorderGestationGoalsGraft RejectionHeterogeneityHistocompatibility AntigensImmuneImmunesImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunosuppressive TherapyInfectionInflammatoryInjectionsIntracellular Communication and SignalingLYT3Laboratory miceLifeLinkMaintenanceMediatingMemoryMicrosurgeryModelingMolecularMonitorPaperPatientsPhenotypePhysiopathologyPredispositionPregnancyProcessProductivityPublishingRegimenRegulatory T-LymphocyteResistanceSignal TransductionSignal Transduction SystemsSignalingSplenocyteSusceptibilityT memory cellT-Cell ActivationT-CellsT-LymphocyteT8 CellsT8 LymphocytesTestingTherapeutic immunosuppressionTimeTransplant RecipientsTransplant RejectionTransplantationTransplantation AntigensTransplantation RejectionTransplantation ToleranceTregaccumulated exposureaccumulated long-term exposureactivate T cellsaggregate exposureartificial immunosuppressionbio-markersbiologic markerbiological signal transductionbiomarkerbiomarker identificationcumulative exposurecumulative life exposurecumulative long-term exposurecytokinedesigndesigningepigenomeglobal gene expressionglobal transcription profileidentification of biomarkersidentification of new biomarkersimmune suppressionimmune suppressive activityimmune suppressive functionimmunogenimmunosuppression therapyimmunosuppressive activityimmunosuppressive functionimmunosuppressive responselife-course exposurelifelong exposurelifespan exposurelifetime exposuremarker identificationmeetingmeetingsmemory T lymphocytememory acquisitionmouse modelmurine modelnew approachesnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel approachesnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathophysiologypreventpreventingprogramsregulatory T-cellsresistantsexsynergismthymus derived lymphocytetotality of exposurestranscriptometransplanttransplant patient
Description preview
Overall Summary
Transplantation tolerance, a state of hyporesponsiveness to donor antigens after cessation of therapy, is an
attractive approach for achieving life-long graft acceptance without global immunosuppression. Tolerance is rare
in the clinic, and even when attained can be lost over time, sometimes after infections. Understanding the…
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