grant
Inborn errors of immunity underlying herpes simplex encephalitis
Organization ROCKEFELLER UNIVERSITYLocation NEW YORK, UNITED STATESPosted 6 Apr 2010Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY20260-11 years old21+ years oldAcicloftalAclovirAcycloguanosineAcyclovirAdultAdult HumanAffectAgeAllelesAllelomorphsArchitectureAutoantibodiesAutoimmuneAutophagocytosisBiochemicalBlood PlasmaBlood leukocyteBrainBrain InflammationBrain Nervous SystemBrain StemBrainstemCD40 Receptor-Associated Factor 1CD40bp ProteinCNS Nervous SystemCRAF1 ProteinCRISPRCRISPR/Cas systemCandidate Disease GeneCandidate GeneCargosilCausalityCell BodyCell DeathCellsCentral Nervous SystemCerebrospinal FluidChildChild YouthChildren (0-21)ClinicalClustered Regularly Interspaced Short Palindromic RepeatsCollectionCommunicable DiseasesCountryDNA mutationDataDermalDiseaseDisorderEgypt 101 virusEncephalitisEncephalonEngineering / ArchitectureEtiologyFLJ11330FibroblastsFore-BrainForebrainFoundationsFrequenciesGenesGeneticGenetic ChangeGenetic DeterminismGenetic HeterogeneityGenetic ModelsGenetic defectGenetic mutationGenotypeHSVHSV encephalitisHSV-1HSV1Hereditary DiseaseHerpes SimplexHerpes Simplex EncephalitisHerpes Simplex InfectionsHerpes Simplex Type 1Herpes Simplex VirusHerpes Simplex Virus 1Herpes Simplex Virus Type 1Herpes encephalitisHerpes labialis VirusHerpes simplex diseaseHerpesvirus 1Herpesvirus hominis diseaseHerpetic EncephalitisHeterogeneityHistoryHumanHuman GeneticsIFNIFN-regulatory factor 3IFNARIFNAR1IFNAR1 geneIRF-3 proteinIRF3IRF3 geneISFG-3ImmunityImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImpairmentIn VitroInborn Genetic DiseasesIndividualInfectionInfectious DiseasesInfectious DisorderInherited disorderInterferon Regulatory Factor 3InterferonsInternationalInvestigationLAP-1 ProteinLaboratoriesLesionLeukocytesLeukocytes Reticuloendothelial SystemLifeMarrow leukocyteMediatingModelingModern ManMolecularMutationNF-Kb-Activating Kinase GeneNGS MethodNGS systemNational Institutes of HealthNatureNerve CellsNerve UnitNeural CellNeuraxisNeurocyteNeurologicNeurologicalNeuronsOrganP113ParentsPathogenesisPathway interactionsPatientsPenetrancePersonsPhenotypePhysiologicPhysiologicalPlasmaPlasma SerumPopulationPopulation GeneticsPoviralPrevalencePreventivePrimary ImmunodeficiencyPrivatizationProductionProsencephalonRIP1RIP3RIPK1RIPK1 geneRIPK3RIPK3 geneRNA SeqRNA sequencingRNAseqReceptor ProteinReceptor-Interacting Protein 3Receptor-Interacting Serine/Threonine Kinase 1Receptor-Interacting Serine/Threonine Protein Kinase 3Recording of previous eventsReportingResearchResistanceReticuloendothelial System, Serum, PlasmaRoleSTAT1STAT1 geneSTAT113STAT2STAT2 geneSTAT91SamplingSiblingsSimplexvirusSmall Nucleolar RNASurvivorsT2KTBK1TBK1 geneTLR3TLR3 geneTNF receptor-associated factor 3TRAF-3TRAF3TYK2TestingTherapeuticTick-Borne EncephalitisTick-borne Viral EncephalitisToll-Like Receptor 3United States National Institutes of HealthVaccinesValidationVariantVariationViralViral EncephalitisViral Infectious EncephalomyelitisViroraxVirusWNVWest Nile EncephalitisWest Nile virusWest Nile virus encephalitisWhite Blood CellsWhite CellZoviraxadulthoodagesautoimmune antibodyautophagyautoreactive antibodycandidate selectioncausationcell typecerebral spinal fluidcohortcongenital immune deficiencycongenital immunodeficiencyconsanguineous familyconsanguineous kindredsconsanguineous pedigreedesigndesigningdisease causationexome sequencingexome-seqgene locusgenetic analysisgenetic determinantgenetic etiologygenetic immune defectgenetic immune deficiencygenetic immunodeficiencygenetic locusgenetic mechanism of diseasegenome mutationgenome scalegenome sequencinggenome-widegenomewidegenomic locationgenomic locushereditary disorderheritable disorderherpes simplex iherpes simplex virus 1 encephalitisherpes simplex virus 1 infectionherpes simplex virus encephalitisherpes simplex virus infectionherpes simplex-1hiPSChistorieshuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsinborn errorinborn errors in immunityinborn errors of immunityinborn immunodeficiencyinduced human pluripotent stem cellsinherited diseasesinherited genetic diseaseinherited genetic disorderinherited immune defectinherited immune deficiencyinherited immunodeficiencyinnovateinnovationinnovativekidskindredloss of functionlow-frequency mutationnecrocytosisneuronalnew diagnosticsnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynext gen sequencingnext generation diagnosticsnext generation sequencingnextgen sequencingnovelnovel diagnosticsnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachparentpathwayphysiologic modelprimary immune defectprimary immune deficiencyrare allelerare mutationrare variantreceptorrecruitresistantscreeningscreeningsself reactive antibodysnoRNAsocial rolespinal fluidtraittranscriptome sequencingtranscriptomic sequencingvalidationswhite blood cellwhite blood corpuscleyoungster
Description preview
PROJECT SUMMARY
Herpes simplex virus 1 (HSV-1) encephalitis (HSE) is the most common sporadic viral encephalitis in Western
countries. Its prevalence peaks in individuals < 18 and > 50 yo. While infection with HSV-1 is innocuous in most
people, HSE is devastating. No vaccine against HSV-1 is available, and acyclovir-treated survivors of HSE often…
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