grant
In vivo targeting of T cells to Enable an HIV Cure
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 8 Jul 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025ABCD-3AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAutologousBasal Transcription FactorBasal transcription factor genesBody TissuesC3XkineCD127CD127 AntigensCD62LCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCDW127CX3CL1CX3CL1 geneCXC3CXC3CCell BodyCell FunctionCell PhysiologyCell ProcessCell Surface ReceptorsCell-Mediated Lympholytic CellsCellsCellular FunctionCellular PhysiologyCellular ProcessChemicalsClinicalCytolytic T-CellCytotoxic T CellCytotoxic T-LymphocytesCytotoxic cellDNA mutationDevelopmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExclusionGeneral Transcription Factor GeneGeneral Transcription FactorsGenetic ChangeGenetic defectGenetic mutationHIVHIV InfectionsHLHRCHTLV-III InfectionsHTLV-III-LAV InfectionsHumanHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsIL-7IL-7 GeneIL-7 ReceptorsIL-7R alpha chainIL-7R-alphaIL-7RalphaIL-7RαIL7IL7 ProteinIL7 ReceptorsIL7 geneIL7RIL7R geneImmuneImmune EvasionImmune mediated therapyImmune responseImmunesImmunologically Directed TherapyImmunologyImmunotherapyIn VitroIn vivo analysisInfectionInterleukin 7 PrecursorInterleukin 7 Precursor GeneInterleukin 7 ReceptorInterleukin 7 Receptor AlphaInterleukin-7Interleukin-7 GeneInterruptionInterventionInvestigatorsJointsK lymphocyteLAM-1 geneLAV-HTLV-IIILECAM1LNHRLSELLYAM-1LYAM1LYT3LigandsLymphadenopathy-Associated VirusLymphatic TissueLymphoid TissueLymphopoietin-1LytotoxicityM mulattaM. mulattaMacaca mulattaMacaca rhesusMediatingMemoryMessenger RNAMiceMice MammalsModern ManModificationMurineMusMutationNK CellsNatural Killer CellsPrimate Immunodeficiency VirusesPrimate LentivirusesPropertyProteinsReceptor ProteinResearch PersonnelResearchersRhesus MacaqueRhesus MonkeySCYD1SELL geneSHIVSIVSecondary toSelectin L GeneSimian Immunodeficiency VirusesSiteSpecificitySubcellular ProcessT cell responseT memory cellT-Cell EpitopesT-CellsT-LymphocyteT-Lymphocyte EpitopesT8 CellsT8 LymphocytesTQ-1TechnologyTestingTherapeuticTissuesTranscription Factor Proto-OncogeneTranscription factor genesTranslatingViralViral LatencyViral reservoirVirus LatencyVirus reservoirVirus-HIVWorkalpha chain interleukin-7 receptorantiretroviral therapyantiretroviral treatmentcell killingchimeric antigen receptorcytokinecytotoxiccytotoxic CD8 T cellscytotoxic CD8 T lymphocytecytotoxicitydeliver mRNAdeliver messenger RNAdelivery system for mRNAdesigndesigningdevelopmentalengineered immune systemepigeneticallyexhaustionexperimentexperimental researchexperimental studyexperimentsgenome mutationhost responseimmune engineeringimmune evasiveimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunoengineeringimmunoresponsein vitro activityin vivoin vivo evaluationin vivo testinginhibitorkiller T celllipid based nanoparticlelipid nanoparticlemRNAmRNA deliverymemory T lymphocytemessenger RNA deliverymigrationnano particle deliverynanoparticle deliverednanoparticle deliverynon-human primatenonhuman primatenovelpathogenperipheral bloodpressurepreventpreventingprogramsreceptorsimian HIVsimian human immunodeficiency virusthymus derived lymphocytetraffickingtranscription factorviral reboundvirus rebound
Description preview
Abstract
CHALLENGE: Autologous cytolytic T cell responses, while effective in killing HIV-infected cells, cannot clear tissue-residing
HIV reservoirs. One hurdle for T cell mediated killing is their restriction to the peripheral blood and absence from secondary
lymphoid tissue (SLT). Recent attempts by investigators in this application to trap…
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