grant
In vivo cell engineering for HIV cure.
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 5 Sept 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAntibody-drug conjugatesAntigenic DeterminantsAntigensAreaB blood cellsB cellB cellsB-Cell DevelopmentB-CellsB-LymphocytesB-cellB220Binding DeterminantsBlood Precursor CellBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemBypassC-C CKR-5C-C CKR-5 GeneC-C Chemokine Receptor Type 5C-C Chemokine Receptor Type 5 GeneCAR T cellsCAR modified T cellsCAR-TCAR-TsCC Chemokine Receptor 5CC-CKR-5CC-CKR-5 GeneCC-CKR5CCCKR5CCCKR5 GeneCCR-5CCR-5 GeneCCR5CCR5 ProteinCCR5 ReceptorsCCR5 geneCD195 AntigenCD195 Antigen GeneCD45CHEMR13CHEMR13 GeneCKR-5CKR-5 GeneCKR5CKR5 GeneCKR5 ReceptorsCMKBR5CMKBR5 GeneCell BodyCell TherapyCellsChemokine (C-C Motif) Receptor 5Chemokine (C-C) Receptor 5Chemokine (C-C) Receptor 5 GeneClinical TrialsCollaborationsDNA TherapyDevelopmentEffector CellEngineered GeneEngineeringEpitopesEvaluationFormulationGP180Gene DeliveryGene ModifiedGene Therapy VectorsGene Transduction AgentGene Transduction VectorsGene Transfer ClinicalGenetic InterventionHIVHIV resistanceHIV resistantHIV-1 Fusion Co-ReceptorHIV-1 Fusion Co-Receptor GeneHematopoietic Progenitor CellsHematopoietic stem cellsHospitalsHuman Immunodeficiency VirusesIn SituInjectionsKnock-outKnockoutLAV-HTLV-IIILMICLY5LentivirinaeLentivirusLightningLymphadenopathy-Associated VirusOrganoidsPTPRCPTPRC genePersonsPopulationPropertyProvirus IntegrationReagentRegimenSHIVSafetySurfaceT cells for CART-CellsT-LymphocyteT200TechnologyTherapeutic StudiesTherapy ResearchTissuesToxic effectToxicitiesVirus-HIVbase editingbase editorblood cell progenitorblood progenitorblood stem cellblood-forming stem cellcell based interventioncell engineeringcell mediated interventioncell mediated therapiescell-based therapeuticcell-based therapycellular engineeringcellular therapeuticcellular therapychallenge in rhesus macaqueschemotherapychimeric antigen T cell receptorchimeric antigen receptor (CAR) T cellschimeric antigen receptor Tchimeric antigen receptor T cellschimeric antigen receptor fusion protein T-cellschimeric antigen receptor modified T cellsconditioningcostcryogeldevelopmentaldirected differentiationexperiencefully-deleted adenoviral vectorfully-deleted adenovirus vectorgene editing platformgene editing systemgene editing technologygene editing toolsgene modificationgene repair therapygene therapygene-based therapygene-editing toolkitgenetic therapygenetically modifiedgenomic therapygutless adenoviral vectorgutless adenovirus vectorgutted adenoviral vectorgutted adenovirus vectorhdAdhelper-dependent adenoviral vectorhelper-dependent adenovirus vectorhematopoietic progenitorhematopoietic stem progenitor cellhemopoietic progenitorhemopoietic stem cellimmunogenin vivoindustrial partnershipindustry partnerindustry partnershipinfected rhesus macaquesinfected rhesus monkeyinfection in rhesus macaquesinfection of rhesus macaquesinhibitorinnovateinnovationinnovativeknockout genelipid based nanoparticlelipid nanoparticlelow and middle-income countriesmemberneutralizing antibodynon-human primatenonhuman primatenovelparticleprogenitor cell poolprogenitor cell populationprogenitor poolprogenitor populationprogramsrecombinaserhesus challengerhesus macaque challengerhesus monkey infectionsimian HIVsimian human immunodeficiency virusstem and progenitor cell populationstem cell poolstem cell populationsupport toolsthymus derived lymphocytevector
Description preview
ABSTRACT
Many innovative gene and cell therapy strategies are being considered for an HIV cure. However, for a cure to
be acceptable to people living with HIV (PLWH), it must not only be effective, but also have a favorable profile
of safety/toxicity, cost, practicality and accessibility. In this Program Project we are focused on developing an
HIV…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click