grant
In-vivo and Ex-vivo Analysis of Tissue S-nitrosothiols in Sepsis
Organization INDIANA UNIVERSITY INDIANAPOLISLocation INDIANAPOLIS, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY20260-11 years old21+ years oldAdmissionAdmission activityAdultAdult HumanAwardBioinformaticsBiologyBloodBlood PlasmaBlood PlateletsBlood Reticuloendothelial SystemBlood VesselsBody TissuesCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCause of DeathCell BodyCell Communication and SignalingCell SignalingCellsCessation of lifeCharacteristicsChemicalsChildChild YouthChildhoodChildren (0-21)Circulatory CollapseClinicalClinical DataDataDeathDevelopmentDevelopment PlansDevelopment and ResearchDevice or Instrument DevelopmentDevicesDiseaseDisorderDysfunctionEducationEducational aspectsEndothelial CellsEndotheliumFoundationsFunctional disorderFundingGoalsHumanImmuneImmunesInterventionIntracellular Communication and SignalingInvestigatorsK-AwardsK-Series Research Career ProgramsLinkMOF syndromeMarrow plateletMeasurementMeasuresMentorsMiceMice MammalsModelingModern ManMonitorMultiple Organ Dysfunction SyndromeMultiple Organ FailureMurineMusNHLBINational Heart, Lung, and Blood InstituteNerve CellsNerve UnitNeural CellNeurocyteNeuronsNitrogen OxidesOutcomePathologicPathway interactionsPeripheralPhotolysesPhysiciansPhysiologicPhysiologicalPhysiologyPhysiopathologyPlasmaPlasma SerumPlateletsPopulationProspective cohortProteinsProteomicsR & DR&DR-Series Research ProjectsR01 MechanismR01 ProgramRefractoryResearchResearch Career ProgramResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearch TechnicsResearch TechniquesResearchersReticuloendothelial System, Serum, PlasmaRoleS-NitrosothiolsSamplingScientistSepsisSeverity of illnessShockSignal TransductionSignal Transduction SystemsSignalingTestingThrombocytesTimeTissuesVascular DiseasesVascular DisorderVascular resistanceWorkadulthoodadverse consequenceadverse outcomeantisepsis treatmentbiological signal transductionblood vessel disordercareercareer developmentchild patientschildren with sepsiscirculatory shockcompound repositioningcompound repurposingdesigndesigningdevelopmentaldevice developmentdifferential expressiondifferentially expresseddisease severitydrug repositioningdrug repurposingextracellular vesiclesin vivoindividuals with sepsisinstrument developmentkidsmortalitymouse modelmultiorgan failuremultiple organ system failuremurine modelneuronalnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeutic uses for existing drugsnew therapeuticsnew therapynew therapy targetnew use of drugnew uses for an approved drugnew uses for existing drugsnext generation therapeuticsnitrosative stressnovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetpathogenpathophysiologypathwaypatients with sepsispediatricpediatric patientspediatric sepsispediatric septicpeople with sepsispersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpharmacological repurposingphotolysispoint of carepredict clinical outcomeprogramsrepositioning approved drugsrepositioning existing drugsrepurpose approved drugsrepurpose approved medicationrepurpose approved therapeuticrepurpose existing drugsrepurpose existing medicationrepurpose existing medicinerepurpose existing therapeuticsrepurpose existing therapiesrepurpose medicinerepurposing a drugrepurposing agentrepurposing candidatesrepurposing established drugsrepurposing established medicationrepurposing existing pharmacological agentsrepurposing medicationrepurposing of already existing drugsrepurposing pharmaceuticalsresearch and developmentrisk stratificationsepsis caresepsis groupssepsis in childrensepsis interventionssepsis managementsepsis patientssepsis populationsepsis subjectssepsis therapeuticssepsis therapysepsis treatmentseptic childrenseptic groupseptic individualsseptic patientsseptic peopleseptic populationseptic subjectseptic therapyseptic treatmentshocksskillssocial rolestratify risksubjects with sepsistherapeutic repositioningtherapeutic repurposingtherapeutic targettherapeutically effectivetranscriptional differencestreat sepsisvascularvascular dysfunctionvasculopathyyoungster
Description preview
PROJECT SUMMARY
Each year there is an estimated eight million deaths globally that are attributed to sepsis. Sepsis is one of the
leading causes of death in the pediatric population. When children die it is often from refractory shock and
development of multi-organ failure. A key driver of this refractory shock is vascular dysfunction. Nitrosative…
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