grant
In Vivo Analyses of Kinase Signaling in Learning/Memory Circuitry
Organization VANDERBILT UNIVERSITYLocation Nashville, UNITED STATESPosted 1 Dec 2023Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY2025Adenosine Cyclic Monophosphate-Dependent Protein KinasesAnimalsAssayBehaviorBehavioralBehavioral AssayBioassayBiogenic AminesBiological AssayBiosensorBrainBrain Nervous SystemCaM KIICaM PK IICaM kinase IICaMKIICell BodyCell Communication and SignalingCell Culture TechniquesCell SignalingCellsClostridium tetani ToxinCyclic AMP-Dependent Protein KinasesDataDefectDissectionDrosophilaDrosophila genusDrug TherapyDysfunctionERK MAP KinasesEncephalonEngineeringEpilepsyEpileptic SeizuresEpilepticsEquilibriumExtracellular Signal Regulated KinasesExtracellular Signal-Regulated MAP KinasesFunctional disorderGeneticGoalsHumanImageIn vivo analysisIndividualIntracellular Communication and SignalingKinasesLearningLigandsMAPK ERK KinasesMapsMemoryMemory DeficitMemory impairmentModelingModern ManMushroom BodiesNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeurocyteNeuronal TransmissionNeuronsNeuropeptidesOutputPKAPathway interactionsPerformancePharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePharmacological TreatmentPharmacologyPharmacotherapyPhasePhosphotransferase GenePhosphotransferasesPhysiopathologyPost-Transcriptional Gene SilencingPredispositionProtein Kinase APublishingRNA InterferenceRNA SilencingRNAiReceptor ProteinRegulationReporterRoleSeizure DisorderSeizuresSensitivity and SpecificitySequence-Specific Posttranscriptional Gene SilencingSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSusceptibilitySynapsesSynapticTestingTetanus ToxinThreonine/Tyrosine Protein KinaseTransgenic OrganismsTransphosphorylasesVisualizationWorkaxon signalingaxon-glial signalingaxonal signalingbalancebalance functionbehavioral impairmentbiological sensorbiological signal transductioncAMP-Dependent Protein Kinasescalcium-dependent CaM kinase IIcalmodulin-dependent protein kinase IIcell culturecell culturesdisease modeldisorder modeldrug interventiondrug treatmentepilepsiaepileptogenicexperienceextracellular signal related kinasefruit flygain of functionglia signalingglial signalingimagingimaging in vivoimaging studyimpaired behaviorimprovedin vivoin vivo evaluationin vivo imagingin vivo testingloss of functionmemory consolidationmemory dysfunctionmutantnerve signalingneural controlneural regulationneural signalingneuromodulationneuromodulatoryneuronalneuronal circuitneuronal circuitryneuronal signalingneuroregulationneurotransmissionnoveloptogeneticspathophysiologypathwaypharmaceuticalpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsreceptorsocial rolesynapsesynapse functionsynaptic functiontooltransgenic
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Project Summary
Circuit-localized kinase signaling in the brain modulates local circuit activity and consequent behavioral output.
An enormous roadblock to understanding this core mechanism has been the inability to image kinase signaling
in vivo, but this barrier has finally been overcome with separation of phases-based activity reporter of…
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