grant
Improving the sensitivity and specificity of diffusion MRI
Organization VANDERBILT UNIVERSITYLocation Nashville, UNITED STATESPosted 1 Apr 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY202521+ years oldAcquired brain injuryAdultAdult HumanAgingAlgorithmic AnalysesAlgorithmic AnalysisAlgorithmsAnalyses of AlgorithmsAnalysis of AlgorithmsAnatomic SitesAnatomic structuresAnatomyAnisotropyApoplexyAtlasesAxonBiophysicsBody TissuesBrainBrain DiseasesBrain DisordersBrain InjuriesBrain Nervous SystemBrain Vascular AccidentCell Communication and SignalingCell SignalingCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeClinicalComplexComputer softwareConfocal MicroscopyDWI (diffusion weighted imaging)DWI-MRIDataDependenceDetectionDevelopmentDiffusionDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDiseaseDisorderEncephalonEncephalon DiseasesEvolutionFascicleFiberFutureGeometryGoalsHistologicHistologicallyHumanHydrogen OxideImageIndividualInjuryIntracellular Communication and SignalingIntracranial CNS DisordersIntracranial Central Nervous System DisordersLeast SquaresLeast-Squares AnalysesLeast-Squares AnalysisLinkMR ImagingMR TomographyMRIMRI biomarkerMRI markerMRIsMagnetic Resonance ImagingMapsMeasurementMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodsMicroscopyModern ManMonitorNMR ImagingNMR TomographyNeural PathwaysNeurosciencesNuclear Magnetic Resonance ImagingOperative ProceduresOperative Surgical ProceduresOpticsPathway interactionsPatientsPopulationProgressive DiseasePropertyRaceRacesRadialRadiusRecoveryReproducibilityResolutionSaimiriSaimirusSample SizeSensitivity and SpecificitySignal TransductionSignal Transduction SystemsSignalingSoftwareSpecificitySquirrel MonkeyStatistical DistributionsStrokeStructureSurgicalSurgical InterventionsSurgical ProcedureSystemTechniquesTestingTimeTissuesValidationWaterZeugmatographyadulthoodbiological signal transductionbiophysical characteristicsbiophysical characterizationbiophysical foundationbiophysical measurementbiophysical parametersbiophysical principlesbiophysical propertiesbiophysical sciencesbrain attackbrain damagebrain tissuebrain-injuredcerebral vascular accidentcerebrovascular accidentdMRIdata acquisitiondata acquisitionsdevelopmentaldiffuseddiffusesdiffusingdiffusion anisotropydiffusion tensor imagingdiffusion weighteddiffusionshuman subjectimage-based methodimagingimaging biomarkerimaging markerimaging methodimaging modalityimaging studyimaging-based biological markerimaging-based biomarkerimaging-based markerimprovedin vivoinjurieslight microscopymagnetic resonance imaging biomarkermagnetic resonance imaging markermillimeterneural imagingneuro-imagingneuroimagingneurological imagingnew approachesnon-human primatenon-invasive imagingnonhuman primatenoninvasive imagingnovel approachesnovel strategiesnovel strategyopen sourceopticalpathwayracialracial backgroundracial originrapid growthresolutionsresponseresponse to therapyresponse to treatmentstrokedstrokessubstantia albasurgerytherapeutic responsetherapy responsetooltractographytreatment responsetreatment responsivenessvalidationswhite matterwhite matter injury
Description preview
PROJECT SUMMARY/ABSTRACT
The ability to detect fiber pathways and assess tissue microstructure in vivo has opened a new window on the
brain, with important applications ranging from brain connectomics to stroke detection and surgical planning.
Diffusion Magnetic Resonance Imaging (DMRI) has the unique ability to reveal anatomical connectivity and…
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