grant
Improving Diagnostics and Neurocognitive Outcomes in HIV/AIDS-related Meningitis
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 1 Sept 2013Deadline 31 May 2029
NIHUS FederalResearch GrantFY202521+ years old5-FC5-FluorocytosineAIDSAIDS VirusAIDS/HIVAccountingAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency SyndromeAcquired Immunodeficiency Syndrome VirusActive Follow-upAdultAdult HumanAfricaAgeAlcobonAlgorithmsAmBAmBisomeAmphocilAmphotecAmphotercin BAmphotericinAmphotericin BAncobonAncotilAnti-HIV PositivityAntigensAssayAzolesBioassayBiologicalBiological AssayCNS infectionCausalityCentral Nervous System InfectionsCentral Nervous System Infectious DiseaseCentral Nervous System Infectious DisorderCessation of lifeClinicalClinical ResearchClinical StudyClinical TrialsConsolidation TherapyCoupledCryptococcal MeningitisCryptococcosisCryptococcusDeathDevelopmentDiagnosisDiagnosticDiagnostic testsDoseEnrollmentEpidemiologyEtiologyFailureFluconazoleFluconazole resistanceFluconazole resistantFlucytosineFungal MeningitisFungizoneGoalsHIVHIV InfectionsHIV PositiveHIV PositivityHIV SeroconversionHIV SeropositivityHIV anti-retroviralHIV antibody positiveHIV therapyHIV/AIDSHTLV-III InfectionsHTLV-III SeroconversionHTLV-III SeropositivityHTLV-III-LAV InfectionsHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsImmune responseIn VitroIncidenceLAV-HTLV-IIILaboratoriesLiposomalLiposomesLymphadenopathy-Associated VirusM tuberculosis infectionM. tb infectionM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionManuscriptsMeningeal TBMeningeal TuberculosisMeningitisMorbidityMorbidity - disease rateMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionMysteclin-FNeurocognitiveNeurologicNeurologic outcomeNeurologicalNeurological disabilityNeurological outcomeOralOutcomePerformancePersonsPhasePopulationProductivityProphylactic treatmentProphylaxisProspective cohortProspective, cohort studyPublishingRandomizedRelapseResearchResistance to FluconazoleSterilizationTB infectionTB meningitisTestingTetrazolesTherapeuticTherapeutic FungicidesTorulaTorulosisTuberculosisTuberculosis MeningitisTuberculous MeningitisUgandaVirus-HIVWhole BloodYeastsactive followupadulthoodagesanti-fungalanti-fungal agentsanti-fungal drugantiretroviral therapyantiretroviral treatmentbiologiccausationdevelopmentaldiagnostic abilitydiagnostic algorithmdiagnostic assaydiagnostic capabilitydiagnostic powerdiagnostic utilitydiagnostic valuediflucandisease causationdisseminated TBdisseminated tuberculosisenrollepidemiologicepidemiologicalexperiencefluorocytosinefollow upfollow-upfollowed upfollowupgene signaturesgenetic signaturehost responsehypoimmunityimmune deficiencyimmune system responseimmunodeficiencyimmunogenimmunoresponseimprovedin vitro activityin vivoinfection due to Mycobacterium tuberculosislateral flow assaylateral flow testmolecular diagnosticsmortalitynew diagnosticsnext generation diagnosticsnovel diagnosticspoint of careprospectiverandomisationrandomizationrandomly assignedresistant to fluconazolestandard of caresurvival predictiontuberculosis infectiontuberculous spondyloarthropathy
Description preview
ABSTRACT
Central nervous system (CNS) infections are common across all ages in Africa in people with or without
HIV-infection. In people with HIV, cryptococcal meningitis has historically been the second most common
AIDS-defining illness in Africa and the most common cause of adult meningitis in Africa overall. The next most
common cause of…
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