grant
Improving bacterial cancer therapeutics
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 1 Mar 2024Deadline 28 Feb 2028
NIHUS FederalResearch GrantFY2025AffectAnti-Cancer AgentsAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsAwardBacteriaBacterial GenesBacterial InfectionsBar CodesBlood CirculationBloodstreamCancer DrugCancer TreatmentCancersClinicalCommunitiesDNA mutationDataDisciplineDoseDrugsE coliE. coliEnvironmentEscherichiaEscherichia coliFellowshipGenesGenetic ChangeGenetic DeterminismGenetic defectGenetic mutationHomingHumanImmuneImmunesImmunologistInfectionInjectionsInvestigatorsKnock-outKnockoutLibrariesLiteratureMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMediatingMedicationMedicineMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMicrobial BiofilmsModelingModern ManMutationNeoplasm MetastasisNeoplastic Disease Chemotherapeutic AgentsOrganPathway interactionsPatientsPharmaceutical PreparationsPhosphodiesterasesPhysiciansProcessProductionPropertyResearchResearch PersonnelResearchersRoleSTING agonistsSalmonellaScientistSecondary NeoplasmSecondary TumorSignal InductionSiteSpecificityTherapeuticTrainingTumor ImmunityTumor TissueTumor-Specific Treatment AgentsWorkanti-canceranti-cancer druganti-cancer immunotherapyanti-cancer therapyanti-tumor immunityanticancer immunotherapyantitumor immunitybacteria infectionbacterial diseasebarcodebiofilmcancer immunitycancer immunotherapycancer metastasiscancer therapycancer-directed therapycomparativedrug/agentearly clinical trialearly phase clinical trialexperimentexperimental researchexperimental studyexperimentsgenetic determinantgenome mutationimmune-based cancer therapiesimmunotherapy for cancerimmunotherapy of cancerimprovedin vitro Assayin vivointravenous administrationintravenous injectionmalignancymigrationmouse modelmurine modelneoplasm/cancerpathwayphosphoric diester hydrolasepromoterpromotorresponsescale upside effectskillssocial roletumortumor cell metastasistumor specificity
Description preview
PROJECT SUMMARY (ABSTRACT)
Bacterial cancer therapy has existed since Dr. William Coley employed deliberate
bacterial infection of tumors over a century ago in the first known example of cancer
immunotherapy. Bacteria are genetically tractable self-replicating therapeutics which can be
tuned to deliver various payloads, modify specificity, and…
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