grant
Importance of Post-translational modifications in Streptococcus mutans pathophysiology
Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 17 May 2013Deadline 31 May 2030
NIHUS FederalResearch GrantFY20256-deoxy-mannoseATP-protein phosphotransferaseAcetylgalactosamineActive SitesAffectAnabolismAnimal ModelAnimal Models and Related StudiesAssayAutoimmune DiseasesAutoregulationBacteriaBacterial AdhesinsBasic ResearchBasic ScienceBindingBinding ProteinsBioassayBiochemicalBiochemical ReactionBioinformaticsBiologicalBiological AssayBiophysicsCarbohydratesCariesCaries preventionCatalysisCell Surface GlycoproteinsCell WallCell membraneCollagenCommon Rat StrainsCryo-electron MicroscopyCryoelectron MicroscopyCytoplasmic MembraneD-GlucoseDataDedicationsDefectDental DecayDental cariesDeoxymannoseDevelopmentDextroseDigestionDiseaseDisorderDysfunctionEC 2.4Electron CryomicroscopyEnzymatic ReactionEnzyme GeneEnzymesFunctional disorderFundingGene TranscriptionGenesGeneticGenetic TranscriptionGenomeGlucoseGlycansGlycoconjugatesGlycoprotein GP-2GlycoproteinsGlycoside TransferasesGoalsGram-Positive BacteriaHomeostasisIn VitroInfective endocarditisInvadedInvestigationKinase Family GeneKnowledgeL-ThreonineLamininLife StyleLifestyleLigand Binding ProteinLigand Binding Protein GeneLinkLipidsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMembraneMembrane GlycoproteinsMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMetabolic GlycosylationMethodsMicrobial BiofilmsModelingModificationMolecularMolecular InteractionMureinN acetylgalactosamineNamesNatureOperonOralPathway interactionsPeptide Signal SequencesPeptidoglycanPersonsPhenotypePhosphatesPhosphorylationPhysiological HomeostasisPhysiopathologyPlasma MembranePlayPolysaccharidesPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcessProductionProtein BindingProtein ExportProtein Export PathwayProtein GlycosylationProtein KinaseProtein ModificationProtein PhosphorylationProteinsProteomeQualifyingRNA ExpressionRatRats MammalsRattusRegulationRhamnoseRiskRoleS mutansS. mutansSaccharoseSalivaSeriesSignal PeptideSignal SequencesStreptococcusStreptococcus mutansStressStructureSucroseSurfaceSurface GlycoproteinsSurface ProteinsSystemSystemic infectionTeichoic AcidsTestingThreonineTranscriptionVirulenceadhesinautoimmune conditionautoimmune disorderautoimmunity diseasebiofilmbiologicbiophysical foundationbiophysical principlesbiophysical sciencesbiosynthesisbound proteincariogenic biofilmcartilage link proteincell envelopecryo-EMcryoEMcryogenic electron microscopydental biofilmdental caries preventiondevelopmentalfitnessglycogen synthase a kinaseglycosylationglycosyltransferasehydroxyalkyl protein kinaseinfection mouthinnovateinnovationinnovativeinorganic phosphatelink proteinmembrane structuremodel of animalmodel organismmutantnamenamednamingnanodisknoveloral infectionoral infectiousorganic acidparticlepathogenpathophysiologypathwayphosphorylase b kinase kinaseplaque biofilmplasmalemmaprotein signal sequenceproteoliposomessocial rolesortasesrtA gene productsugartooth decaytooth surfacetrait
Description preview
Abstract
Dental caries affects 2.5 billion people worldwide. Streptococcus mutans is an important pathogen in dental
caries due to its biofilm lifestyle, and acidogenic and aciduric nature. In addition, expression of the collagen
binding protein Cnm, present in 20% of the strains, by S. mutans is intimately associated with severe caries,
systemic…
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