grant
Implantable, Degradable Drug Delivery Devices for Non-Opioid Post-Surgical Pain Management
Organization UNIVERSITY OF CONNECTICUT STORRSLocation STORRS-MANSFIELD, UNITED STATESPosted 17 Mar 2026Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY20260-11 years old21+ years oldAbdomenAction PotentialsAddressAdultAdult HumanAmericanAnalgesia TestsAnesthestic DrugsAnesthetic AgentsAnesthetic DrugsAnestheticsAnimal ModelAnimal Models and Related StudiesAutonomic painBindingBiocompatible MaterialsBiomaterialsBlood PlasmaBody TissuesBupivacaineCatheterizationCell SurvivalCell ViabilityChildChild YouthChildren (0-21)ClinicalClinical TrialsCommon Rat StrainsConduction-Blocking AnestheticsDevice DesignsDevicesDiffusionDorsal Root GangliaDoseDrug ControlsDrug DeliveryDrug Delivery SystemsDrug KineticsDrug usageDrugsEffectivenessEnvironmentEvaluationFibroblastsFilmFormulationFoundationsHistologicHistologicallyHumanHuman FigureHuman bodyHydrolysisHydrophobicityImmune responseImplantIn VitroInfantInflammationLegal patentLinkLocal AnestheticsLocationMarket ResearchMeasurementMeasuresMedicationMethodsMiceMice MammalsModelingModern ManMolecular InteractionMurineMusNatureNerveNerve BlockNeural BlockNeural BlockadeNociception TestsOperative ProceduresOperative Surgical ProceduresOpiatesOpioidOtomyOutcomePainPain AssessmentPain ControlPain MeasurementPain TherapyPain managementPain measurePainfulPatentsPatientsPeritoneumPharmaceutical AgentPharmaceutical PreparationsPharmaceuticalsPharmacokineticsPharmacologic SubstancePharmacological SubstancePlasmaPlasma SerumPolymersPost-operative PainPostoperative PainPredispositionProceduresProtein BiosynthesisProteinsPublic HealthRatRats MammalsRattusResearchReticuloendothelial System, Serum, PlasmaRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRiskSafetyScientistSilkSiteSpecific qualifier valueSpecifiedSpinal GangliaSurfaceSurgeonSurgicalSurgical InterventionsSurgical ProcedureSurgical incisionsSurgical suturesSusceptibilitySuturesTechniquesTechnologyTherapeuticTimeTissuesTransmissionVariantVariationVisceral painVisualWorkabdominal walladulthoodanimal efficacybiocompatibilitybiological materialbiomaterial compatibilitychronic painclinical significanceclinically significantcontrolled releasedesigndesigningdiffuseddiffusesdiffusingdiffusionsdorsal root gangliondrug usedrug/agentefficacy testingexperiencefirst in manfirst-in-humanflexibilityflexiblehealinghost responsehydrophilicityimmune system responseimmunoresponseimplantationimprovedin vivoincisioninnovateinnovationinnovativekidsliquid formulationlocal drug deliverymanufacturemeetingmeetingsmodel of animalmultidisciplinarynew approachesnon-narcotic analgesicnon-opiate analgesicnon-opioidnon-opioid analgesicnon-opioid therapeuticsnonnarcotic analgesicsnonopiate analgesicnonopioidnonopioid analgesicsnovelnovel approachesnovel strategiesnovel strategyopiate abuseopiate drug abuseopioid abuseopioid drug abusepain after surgerypain assaypain interventionpain reductionpain scalepain scorepain treatmentpharmaceuticalpharmacokinetic modelpolymerpolymericpost-surgical painpostsurgical painprotein synthesisreduce painresponseropivacainesafety assessmentsuccesssurgerysystemic toxicitytransmission processyoungster
Description preview
One out of every nine Americans has surgery each year and 30-80% experience uncontrolled postoperative
pain. There is a clear need to 1) localize treatment to simplify delivery and avoid systemic toxicity, 2) achieve
long duration release to span the duration of postoperative pain without the need for opioids, and 3) deliver
adequate pain control…
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