grant
Impact of Zika Virus Infection on Fetal Innate and Adaptive Immunity
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 12 Jul 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025(TNF)-α1st trimester21+ years old3rd trimesterACT2AT744.1Act-2AcuteAddressAdultAdult HumanAnimalsAssayAtlasesAutophagocytosisAutopsyB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2BioassayBioinformaticsBiological AssayBloodBlood Reticuloendothelial SystemBody TissuesBrainBrain Nervous SystemBrazilCCL4CCL4 geneCachectinCell BodyCellsCells Placenta-TissueCellular StressCellular Stress ResponseCellular injuryChemokine (C-C Motif) Ligand 4Chemokine, CC Motif, Ligand 4Chronologic Fetal MaturityCollectionCord BloodDataData SetDeveloping fetusELISAEarly Placental PhaseEncephalonEnzyme-Linked Immunosorbent AssayEventFemaleFetal AgeFetal DevelopmentFetal TherapiesFetal TissuesFirst Pregnancy TrimesterFirst TrimesterFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFoundationsFrequenciesGene ExpressionGeneralized GrowthGestationGestational AgeGrowthHPGFHemagglutinating Virus of JapanHepatocyte-Stimulating FactorHourHumanHybridoma Growth FactorIFNIFN-beta 2IFN-regulatory factor 3IFNB2IL-6IL6 ProteinIRF-3 proteinIRF3IRF3 geneImmuneImmune Activation 2Immune Cell ActivationImmune Response GenesImmune signalingImmunesImmunoblottingImmunochemical ImmunologicImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImmunologicImmunologicalImmunologicallyImmunologicsImmunologyImmunomodulationInfectionInflammationInflammatoryInflammatory ResponseInjuryInnate Immune ResponseInnate ImmunityInterferon Regulatory Factor 3InterferonsInterleukin-6Ir GeneKnowledgeLast TrimesterLinkLiquid substanceLytotoxicityMGI-2MIP1BMIP1B1Macrophage Inflammatory Protein 1-BetaMacrophage-Derived TNFMeasuresMetabolicModelingModern ManMonocyte-Derived TNFMyeloid Differentiation-Inducing ProteinNHP modelsNative ImmunityNatural ImmunityNon-Specific ImmunityNonspecific ImmunityNormal PlacentomaOrganPathogenesisPathway interactionsPlacentaPlacenta Embryonic TissuePlacentomePlasmacytoma Growth FactorPredispositionPregnancyPremature BirthPrematurely deliveringPreterm BirthProductionRegulationSCYA4Sendai virusSignal PathwaySmall Inducible Cytokine A4SpleenSpleen Reticuloendothelial SystemStaining methodStainsStimulusSusceptibilitySystemTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTherapeuticThird Pregnancy TrimesterThird TrimesterThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemTissue GrowthTissuesTumor Necrosis FactorTumor Necrosis Factor-alphaUmbilical Cord BloodViralViral DiseasesVirusVirus DiseasesVirus ReplicationWestern BlottingWestern ImmunoblottingWhole BloodZIKVZIKV infectedZIKV infectionZIKV positiveZika VirusZika virus infectionadaptive immune responseadaptive immunityadulthoodautophagybiological adaptation to stresscell damagecell injurycell stresscellular damagecytokinecytotoxicitydamage to cellsenzyme linked immunoassayexperimentexperimental researchexperimental studyexperimentsfetalfetal bloodfetal brain injuryfetal cellfetal cord bloodfetal inflammatory response syndromefetus cellfetus therapyfetus tissueflow cytophotometryfluidfunctional genomicsgene networkhigh dimensional datahuman fetal tissuehuman fetus tissueimmune activationimmune modulationimmune regulationimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryin utero therapyin vivoinfected with ZIKVinfected with zikainjuriesinjury responseinjury to cellsinjury to organsinnate immune pathwaysinnovateinnovationinnovativeinterferon beta 2liquidlymph organlymphatic organlymphoid organmalemultidimensional datamultidimensional datasetsnanostringnecropsyneuroprotectionneuroprotectivenew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnon-human primatenonhuman primatenonhuman primate modelsnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetontogenyorgan injurypathwaypostmortempregnantpremature childbirthpremature deliveryprenatal therapypreterm deliveryprogramsprotein blottingreaction; crisisresponseresponse to injuryscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingstress responsestress; reactionsubcutaneoussubdermaltoolviral infectionviral multiplicationviral replicationvirus infectionvirus multiplicationvirus-induced diseasezika infectedzika infectionzika viral infectionzikav♀♂
Description preview
PROJECT SUMMARY
The objective of this proposal is to define the impact of maternal viral infections and inflammation on immune
programming within the fetal brain and lymphoid organs in a well-defined non-human primate (NHP) model.
Discoveries in fetal human immunology have primarily come from human cord blood with few studies of fetal
blood or the…
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