grant
Impact of neurovascular coupling on receptor-mediated transport of proteins into the brain
Organization PENNSYLVANIA STATE UNIVERSITY, THELocation UNIVERSITY PARK, UNITED STATESPosted 3 Sept 2025Deadline 2 Sept 2028
NIHUS FederalResearch GrantFY20252-photon2-photon microscopy22-kD Gene Caveolae Protein22kD Caveolae Protein22kD Gene Caveolin 1 Caveolae ProteinAcetazolamideActive Biologic TransportActive Biological TransportActive TransportAffectAlpha Isoform Gene Caveolin 1AnimalsApoplexyArteriesBBB permeabilizationBBB permeableBeta Isoform Gene Caveolin 1BloodBlood - brain barrier anatomyBlood PlasmaBlood ProteinsBlood Reticuloendothelial SystemBlood VesselsBlood capillariesBlood-Brain BarrierBrainBrain Nervous SystemBrain Vascular AccidentBrain regionCAV GeneCAV1CAV1 geneCarrier ProteinsCaveolaeCaveolasCaveolin 1, Caveolae Protein, 22kDCaveolin ProteinsCaveolin-1 GeneCaveolinsCell BodyCell Communication and SignalingCell SignalingCellsCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeClathrinCommunicationContralateralCoupledDNA Molecular BiologyDREADDsDegenerative Neurologic DisordersDiameterDiseaseDisorderEncephalonEndocytosisEndothelial CellsEndotheliumExposure toFailureFluorescenceFluorescence AgentsFluorescent AgentsFluorescent DyesHealthHemato-Encephalic BarrierHistologicHistologicallyImageIndocinIndometacinIndomethacinIntegral Membrane ProteinIntracellular Communication and SignalingIntrinsic Membrane ProteinInvestigatorsKnowledgeLabelLigandsMediatingMembraneMentorsMiceMice MammalsMolecular BiologyMonitorMovementMurineMusNerve CellsNerve DegenerationNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationNeuronsPathologicPenetrationPhysiologicPhysiologicalPlasmaPlasma ProteinsPlasma SerumPopulationPrincipal InvestigatorProcessProtein TraffickingProteinsProteomePyramidal neuronReceptor ProteinResearchResearch PersonnelResearchersReticuloendothelial System, Serum, PlasmaRoleSensorySignal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling MoleculeSignaling Pathway GeneSignaling ProteinSiteStrokeTestingTrainingTransmembrane ProteinTransmembrane Protein GeneTransport Protein GeneTransport ProteinsTransporter ProteinUphill TransportVIP21VIP21 GeneVIP21 proteinVasodilatationVasodilationVasorelaxationVeinsVibrissaeVisualizationWhiskersWorkarterioleawakebiological signal transductionblood-brain barrier permeabilizationblood-brain barrier permeablebloodbrain barrierbloodbrain barrier permeabilizationbloodbrain barrier permeablebody movementbrain attackcapillarycareercaveolin 1cell typecerebral vascular accidentcerebrovascular accidentconstrictiondegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdesigner receptors exclusively activated by designer drugsexperimentexperimental researchexperimental studyexperimentsfluorescent dye/probehemodynamicshippocampal pyramidal neuronimagingin vivomechanical propertiesmembrane structureneuralneural degenerationneural stimulationneuro-vascular couplingneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneuronalneuronal degenerationneurovascular couplingnovelpharmacologicprotein transportreceptorresponsesmall moleculesocial rolespatial and temporalspatial temporalspatiotemporalstrokedstrokestargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttranscytosistwo photon excitation microscopytwo photon microscopytwo-photonuptakevascularvascular constrictionvascular contributionsvasoconstrictionvesicular integral membrane protein 21 kDa
Description preview
PROJECT SUMMARY
Transport of blood-borne signals into the brain must be tightly controlled to maintain neuronal health. Selective
transport across endothelial cells is achieved by receptor-mediated transcytosis, yet little is known about what
physiological signals stimulate this transport. Transcytosis is affected by alterations in membrane…
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