grant
Impact of Metals on Biological Aging and Cardiometabolic Traits in Adolescents
Organization BOSTON UNIVERSITY MEDICAL CAMPUSLocation BOSTON, UNITED STATESPosted 1 Jun 2022Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY202611 year old11 years of age12-20 years old21+ years oldAddressAdolescenceAdolescentAdolescent YouthAdultAdult HumanAdverse effectsAffectAgeArsenicBMIBMI percentileBMI z-scoreBangladeshBiological AgingBiometricsBiometryBiosensorBiostatisticsBlood PressureBlood leukocyteBody mass indexC-reactive proteinCadmiumCardiovascular DiseasesCd elementChild HealthChildhoodCholesterolClipDNADNA MethylationDataDeoxyribonucleic AcidDevelopmentDisparity populationDysfunctionEnvironmentEnvironmental FactorEnvironmental Risk FactorEpidemiologic ResearchFrequenciesFunctional disorderFutureGeneral PopulationGeneral PublicGoalsHealthHg elementHumulin RIndividualInsulinKnowledgeLaboratoriesLeadLearningLengthLeukocytesLeukocytes Reticuloendothelial SystemLifeLife CycleLife Cycle StagesLiteratureMarrow leukocyteMeasuresMediationMercuryMetal exposureMetalsMethodsMethylationNegotiatingNegotiationNovolin ROutcomePathogenesisPb elementPhenotypePhysiopathologyPoisonPopulation StudyPredispositionProteins, specific or class, C-reactivePublic HealthQuetelet indexRegular InsulinResearchResearch ResourcesResourcesRisk ReductionRuralSamplingSiteSpottingsStructure of nail of toeSusceptibilityTestingTimeToe NailToenailToxic ChemicalToxic SubstanceToxic effectToxicitiesUrineVisitVulnerable PopulationsWhite Blood CellsWhite CellWhole BloodYouthYouth 10-21adolescence (12-20)adulthoodage 11age 11 yearsagesarsenicsbiological process of agebiological sensorcardiometaboliccardiometabolic riskcardiometabolismcardiovascular disordercardiovascular riskcardiovascular risk factorco-exposuresco-occurring exposurecohortcombined exposurecomplex exposureconcurrent exposuredevelopmentaldisadvantaged groupdisadvantaged individualdisadvantaged peopledisadvantaged populationdisadvantaged subgroupdisease preventiondisease registrydisorder preventiondisparities across groupsdisparity across subgroupsdisparity among groupsdisparity among subgroupsdisparity between groupsdisparity between subgroupseleven year oldeleven years of ageenvironmental riskepidemiologic investigationepigenomeexposed human populationexposure mixtureexposure to metalfasting plasma glucosegroup disparitygroup inequalitygroup inequityheavy metal Pbheavy metal leadhigh riskhuman exposureimprovedinequalities among populationsinequalities between populationsinequalities in populationsinequality across populationsinequality among groupsinequality between groupsinequality in groupsinequities among populationsinequities between populationsinequities in populationsinequity across groupsinequity across populationsinequity between groupsinequity in groupsinnovateinnovationinnovativeinsightinvestigate epidemiologyjuvenilejuvenile humanlater in lifelater lifelife coursemixed exposurenovelparticipant enrollmentpathophysiologypatient enrollmentpediatricpopulation inequalitypopulation inequitypopulation research studypopulation surveypopulation-based studypopulation-level studyreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskremediationrisk-reducingsimultaneous exposuresstudy epidemiologysubgroup disparitysurvey epidemiologytelomeretoxic compoundtoxic metaltraitunequal groupunequal populationvulnerable groupvulnerable individualvulnerable peoplewhite blood cellwhite blood corpuscleyouth age
Description preview
ABSTRACT
The ubiquitous presence of toxic metal exposures in the environment is a global public health concern, with
disadvantaged populations disproportionately exposed and susceptible to adverse effects. Lead, arsenic,
cadmium, and mercury are the most commonly occurring toxic environmental metal exposures in the general
population. These metal…
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