grant
Impact of circulating and tissue-specific lipids on vascular function and insulin sensitivity in chronic night shift workers
Organization COLORADO STATE UNIVERSITYLocation FORT COLLINS, UNITED STATESPosted 5 Feb 2024Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY20251,2-diacylglycerol21+ years oldAKTAcuteAdultAdult HumanAdult-Onset Diabetes MellitusAkt proteinArmed Forces PersonnelBP reductionBehaviorBiologicalBiologyBiopsyBlood PlasmaBlood PressureBlood SampleBlood VesselsBlood specimenBody TissuesCalcium Phospholipid-Dependent Protein KinaseCalcium-Activated Phospholipid-Dependent KinaseCaloric IntakeCardiometabolic DiseaseCardiometabolic DisorderCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCeramidesChronicCircadian DysregulationCircadian desynchronyCirculationContinuous Glucose MonitorCross-Over StudiesCrossover StudiesD-GlucoseDataDevelopmentDextroseDiacylglycerolsDiastolic PressureDiastolic blood pressureDiglyceridesDiseaseDisorderEDN1ET-1EatingEmergency medical serviceEndothelin Type 1Endothelin-1EndotheliumEnergy IntakeEuglycemic ClampingEuglycemic-hyperinsulinemic ClampEventFood IntakeFree Fatty AcidsFutureGlucoseGlucose ClampGoalsHealthHealth CareHeart VascularHospitalsHourHumanHumulin RHyperinsulinemic ClampImmunoblottingImpaired DrivingImpairmentIndividualInpatientsInsulinInsulin ResistanceIsoformsKetosis-Resistant Diabetes MellitusKnowledgeLeannessLipidsMaturity-Onset Diabetes MellitusMediatingMetabolicMilitaryMilitary PersonnelModelingModern ManMuscleMuscle TissueNIDDMNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNonesterified Fatty AcidsNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RNursesObesityOut-patientsOutcomeOutpatientsOver weightOverweightPAI-1PAI1PLANH1ParamedicParamedical PersonnelParticipantPersonsPhospholipid-Sensitive Calcium-Dependent Protein KinasePhysical activityPlasmaPlasma SerumPlasminogen Activator Inhibitor 1PolicePolysomnographyPopulationProtein AnalysisProtein IsoformsProtein Kinase BProtein Kinase CProto-Oncogene Proteins c-aktProtocolProtocols documentationPublishingRAC-PK proteinRandomizedRegular InsulinReticuloendothelial System, Serum, PlasmaRiskRisk FactorsSecuritySerine or Cysteine Proteinase Inhibitor Clade E Member 1SleepSleep MonitoringSleep disturbancesSlow-Onset Diabetes MellitusSomnographyStable Diabetes MellitusT2 DMT2DT2DMTestingThinnessTimeTime-restricted eatingTime-restricted feedingTissuesTranslatingTransportationTriacylglycerolTriglyceridesType 1 Plasminogen Activator InhibitorType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesVEGFVEGFsVascular Endothelial Growth FactorsVascular EndotheliumWestern BlottingWestern ImmunoblottingWorkaberrant sleepadiposityadult onset diabetesadulthoodawakebiologicblood glucose regulationblood pressure elevationblood pressure reductionc-akt proteincaloric dietary contentcardiometaboliccardiometabolismcardiovascular disease riskcardiovascular disordercardiovascular disorder riskcardiovascular healthcircadiancircadian abnormalitycircadian desynchronizationcircadian disruptioncircadian disturbancecircadian dysfunctioncircadian impairmentcircadian misalignmentcirculating biomarkerscirculating markerscirculatory systemcontinuous blood glucose monitorcontinuous blood sugar monitorcontinuous glucose measurementcontinuous monitoringcontinuous sugar monitorcorpulencecost effectiveday shiftdevelopmentaldiacylglyceroldietarydiglyceridedisease riskdisorder riskdisrupted sleepdisturbed sleepdriving while impairedeat lesselevated blood pressureemergency serviceendothelial dysfunctionenergy balanceexperienceexposure to lightexposure to visible lightfire fighterfire servicesfirefighterglucose controlglucose homeostasisglucose regulationhigh riskimpaired driving performanceimpaired sleepimprovedincrease in blood pressureincreased blood pressureinsulin resistantinsulin sensitivityinsulin signalinginsulin toleranceinterstitialirregular sleepketosis resistant diabeteslight exposurelight pollution exposurelipidomicslower BPlower blood pressurelowers blood pressuremanufacturematurity onset diabetesmilitary populationmuscularnight shiftnight worknurseprogramsprotein blottingproto-oncogene protein RACproto-oncogene protein aktrac protein kinaserandomisationrandomizationrandomly assignedreduce BPreduce blood pressurereduced eatingreduced food intakereduction in BPreduction in blood pressurerelated to A and C-proteinshift workshiftworksleep disruptionsleep dysregulationsleep measurementsleep polysomnographysleep/wake disruptionsleep/wake disturbancetime usetype 2 DMtype II DMtype two diabetesvascular
Description preview
PROJECT SUMMARY/ABSTRACT
There is growing recognition that timing of behaviors, such as eating, sleeping, and physical activity, have a
significant impact on human health and disease risk. For example, when people are awake at the “wrong” time of the day
(i.e. during the biological night), a mismatch occurs between behavior and biology, termed…
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