grant
Impact of Cannabinoid Across the Lifespan (ICAL)
Organization UNIVERSITY OF CALIFORNIA-IRVINELocation IRVINE, UNITED STATESPosted 1 Jul 2018Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY202512-20 years old21+ years old9-ene-TetrahydrocannabinolAdolescenceAdolescentAdolescent YouthAdultAdult HumanAnalytic ChemistryAnalytical ChemistryAnimalsArchitectureAssayBehaviorBehavioralBioassayBiocompatible MaterialsBiological AssayBiomaterialsBody TissuesCNS plasticityCannabinoidsCognitionCommon Rat StrainsD9-tetrahydrocannabinolDelta-9-TetrahydrocannabinolDrug KineticsEndocannabinoidsEndogenous CannabinoidsEngineering / ArchitectureEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEquipmentExposure toFundingGenetic ProcessesHumanLipidsLiquid ChromatographyLong-Term EffectsMacromolecular StructureMaintenanceMethodsMiceMice MammalsModern ManMolecularMolecular StructureMurineMusN arachidonoyl 2 hydroxyethylamideN-arachidonoylethanolamineNIDANational Institute of Drug AbuseNational Institute on Drug AbuseNeuranatomiesNeuranatomyNeuroanatomiesNeuroanatomyNeuronal PlasticityPK/PDPharmacokineticsPostdocPostdoctoral FellowPreparationProcessPropertyPublicationsRatRats MammalsRattusResearch AssociateSamplingScheduleScientific PublicationSeriesSynapsesSynapticSystemTHC co-useTHC useTeenTeenagersTestingTetrahydrocannabinolTetrahydrocannabinol co-useTetrahydrocannabinol useTissuesTrainingTreatment ProtocolsTreatment RegimenTreatment Scheduleadolescence (12-20)adulthoodanandamidearachidonoyl ethanolamidearachidonoylethanolamidearachidonylethanolamidebiological materialcannabinoid drugcannabinoid-based compoundcannabinoid-based drugcannabinoid-based medicationcannabinoid-based pharmaceuticalcannabis usecentral nervous system plasticitydelta(1)-THCdelta(1)-Tetrahydrocannabinoldelta(9)-THCdelta(9)-Tetrahydrocannabinoldrug metabolismeCB systemendocannabinoid systemendogenous cannabinoid systemepigeneticallyexperiencegraduate studentinnovateinnovationinnovativeinstrumentationjuvenilejuvenile humanlife spanlifespanmarijuana usemotivated behaviorneural plasticityneuroplasticneuroplasticitynew approachesnovelnovel approachesnovel strategiesnovel strategypharmacokinetics and pharmacodynamicspost-docpost-doctoralpost-doctoral traineepreparationsresearch associatessexsynapsesynapse functionsynaptic functiontandem mass spectrometryteen yearsteenageΔ(1)-THCΔ(1)-tetrahydrocannabinolΔ(9)-THCΔ(9)-tetrahydrocannabinolΔ-9-tetrahydrocannabinolΔ9-tetrahydrocannabinol
Description preview
ICAL ANALYTICAL CORE: SUMMARY
The NIDA Center of Excellence Impact of Cannabinoids Across the Lifespan (ICAL), whose renewal is
proposed in this revised application, tests the hypothesis that non-physiological activation of the
endocannabinoid system during adolescence – caused by exposure to D9-tetrahydrocannabinol (THC) –
initiates a…
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