grant
Impact of anti-anaerobic antibiotics on clinical outcomes and the microbiome in hospitalized Veterans
Organization VETERANS HEALTH ADMINISTRATIONLocation ANN ARBOR, UNITED STATESPosted 1 Mar 2024Deadline 28 Feb 2029
VANIHUS FederalResearch GrantFY202516S RNA sequencing16S RNAseq16S gene sequencing16S rDNA amplicon sequencing16S rRNA DNA sequencing16S rRNA amplicon sequencing16S rRNA gene amplicon sequencing16S rRNA gene sequencing16S rRNA genomic profiling16S rRNA sequencing16S ribosomal RNA gene sequencing16S ribosomal RNA sequencing16S seq16S sequencing16s rRNA seqASCVDAccelerationAnaerobic BacteriaAnatomic SitesAnatomic structuresAnatomyAntibiotic AgentsAntibiotic DrugsAntibiotic TherapyAntibiotic TreatmentAntibioticsAtherosclerosisAtherosclerotic Cardiovascular DiseaseB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2BacteriaBig DataBig Data AnalyticsBig Data MethodsBig Data ToolsBigDataBiologicalBiometricsBiometryBiostatisticsBlood SerumCOVID crisisCOVID epidemicCOVID pandemicCOVID-19 crisisCOVID-19 epidemicCOVID-19 eraCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 pandemicCOVID-19 periodCOVID-19 public health crisisCOVID-19 yearsCancersCaringCefepimeCessation of lifeCirculationCirculatory CollapseCirrhosisClinicalClinical DataClinical ManagementClinical ResearchClinical SciencesClinical StudyClinical TreatmentColiform BacilliCommunicable DiseasesCommunitiesComputerized Medical RecordDataData AnalysesData AnalysisDeathDevelopmentDevelopment and ResearchDiseaseDisorderDrugsElectronic Medical RecordEnteric BacteriaEnterobacteriaEnterobacteriaceaeEnterobacteriaceae InfectionsEnterobacteriaceae diseaseEnterobacterial InfectionsEnvironmentFoundationsFutureGI microbiomeGeneralized GrowthGoalsGrowthGut Epithelial PermeabilityGut HyperpermeabilityGut permeabilityHPGFHealthHepatocyte-Stimulating FactorHospital AdmissionHospital InfectionsHospital acquired infectionHospitalizationHybridoma Growth FactorIFN-beta 2IFNB2IL-6IL6 ProteinImmune responseImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsInfectionInfectious DiseasesInfectious DisorderInflammationInterleukin-6InternationalIntestinalIntestinal Epithelial PermeabilityIntestinal HyperpermeabilityIntestinal permeabilityIntestinesInvestigatorsKnowledgeLPS-binding proteinLearningLength of StayMGI-2Malignant NeoplasmsMalignant TumorMaster of ScienceMaster's DegreeMeasuresMedicationMentorsMentorshipMetabolicMethodsMichiganMicrobiomicsMiscellaneous AntibioticModelingMolecularMyeloid Differentiation-Inducing ProteinNatural experimentNosocomial InfectionsNumber of Days in HospitalOrganOutcomePathogenicityPatientsPharmaceutical PreparationsPhysiciansPhysiologicPhysiologicalPhysiologyPiperacillin-TazobactamPlasmacytoma Growth FactorPositionPositioning AttributeProspective StudiesProspective, cohort studyPublishingR & DR&DResearchResearch DesignResearch InfrastructureResearch PersonnelResearch PriorityResearch ResourcesResearchersResourcesRetrospective cohort studySARS-CoV-2 epidemicSARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 pandemicSARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicSamplingSerumSevere Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 pandemicShockSiteSkinStatistical MethodsStudy TypeTazocelTazocinTechniquesTestingTimeTissue GrowthTrainingTraining SupportTranslatingTranslational ResearchTranslational ScienceUniversitiesUpper respiratory tractVeteransWorkZosynanaerobeanti-microbialantimicrobialatheromatosisatherosclerotic diseaseatherosclerotic vascular diseasebacterial disease treatmentbacterial infectious disease treatmentbiologicbiomarker validationbowelcareer developmentcefepimcirculatory shockcirrhoticclinical centerclinical interventionclinical therapycoronavirus disease 2019 crisiscoronavirus disease 2019 epidemiccoronavirus disease 2019 global health crisiscoronavirus disease 2019 global pandemiccoronavirus disease 2019 health crisiscoronavirus disease 2019 pandemiccoronavirus disease 2019 public health crisiscoronavirus disease crisiscoronavirus disease epidemiccoronavirus disease pandemiccoronavirus disease-19 global pandemiccoronavirus disease-19 pandemicdata interpretationdata warehouseddPCRdevelopmentaldigestive tract microbiomedroplet digital PCRdroplet digital Polymerase Chain Reactiondroplet-based digital PCRdrug/agententeric microbiomeexperiencegastrointestinal microbiomegut microbiomegut-associated microbiomehospital dayshospital length of stayhospital stayhost microbiomehost responseimmune system responseimmunoresponseimprovedinstitutional infectioninterferon beta 2intestinal biomeintestinal fatty acid binding proteinintestinal microbiomelipopolysaccharide-binding proteinmalignancymarker validationmicrobial consortiamicrobial floramicrobiomemicrobiome community compositionmicrobiome compositionmicrobiome researchmicrobiome sciencemicrobiome species compositionmicrobiome structuremicrobiome studiesmicrobiotamicrofloramortalitymultispecies consortianeoplasm/cancerontogenypatient centeredpatient orientedprospectiveresearch and developmentsevere acute respiratory syndrome coronavirus 2 global health crisissevere acute respiratory syndrome coronavirus 2 global pandemicshocksskillsstatistic methodsstudy designsystemic inflammationsystemic inflammatory responsetherapy optimizationtranslation researchtranslational investigationtranslational pipelinetranslational spectrumtreatment optimizationtrial regimentrial treatmentupper airway tract
Description preview
Candidate: This is a Career Development proposal for Dr. Rishi Chanderraj, an Infectious Diseases physician
with a Master's degree in Clinical Research Design and Biostatistics and expertise in integrating microbiome
and clinical data for translational research.
Specific aims: This proposal aims to test the hypothesis that depletion of gut…
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