grant
Impact of a Dual Function Type VI Secretion System (T6SS) Immunity Protein on Airway Microbiota
NIHUS FederalResearch GrantFY2026AffectAlimentary CanalBacteriaBacterial GenomeBasal Transcription FactorBasal transcription factor genesBindingBiochemicalBiologic ModelsBiological ModelsBionomicsBurkholderiaCF airwayCF airway epitheliaCF lung diseaseCF patientsCell BodyCell ProtectionCell modelCell-Extracellular MatrixCellsCellular modelCystic FibrosisCytoprotectionDNA BindingDNA Binding DomainDNA Binding InteractionDNA boundDNA-Binding Protein MotifsDefectDigestive TractECMEcologyEpithelial CellsEvolutionExtracellular MatrixGI TractGastrointestinal TractGastrointestinal tract structureGene TranscriptionGeneHomologGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenesGeneticGenetic TranscriptionGenomic approachGrowthHealthHomologHomologous GeneHomologueHumanImmunityInfectionIntermediary MetabolismIntoxicationInvadedIonsLong-term infectionMediatingMetabolic ProcessesMetabolismMicrobeMicrobial BiofilmsModel SystemModelingModern ManMolecularMolecular InteractionMorbidityMucous body substanceMucoviscidosisMucusOperonOrganismOutcomeP aeruginosaP. aeruginosaP. aeruginosa infectionPathologicPathway interactionsPersonsPlayPopulationPromoter RegionsPromotor RegionsProteinsPseudomonas aeruginosaPseudomonas aeruginosa infectionPseudomonas pyocyaneaPulmonary Body SystemPulmonary Cystic FibrosisPulmonary Organ SystemRNA ExpressionRegulationReportingRespiratory EpitheliumRespiratory SystemRespiratory TractsRespiratory infectious agentRespiratory tract pathogenRespiratory tract structureRoleSiteStructure of respiratory epitheliumSystemTestingThickThicknessTissue GrowthToxic effectToxicitiesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesUpper respiratory tractWorkairway colonizationairway epitheliumairway microbial communityairway microbiotaalimentary tractbacteria pathogenbacterial pathogenbiofilmbiofilm communitybronchial epitheliumchronic infectioncommunity microbescystic fibrosis airwaycystic fibrosis airway epitheliacystic fibrosis lungcystic fibrosis lung diseasecystic fibrosis patientscytoprotectivedigestive canaldisease modeldisorder modelfitnessgenetic approachgenetic promoter elementgenetic promoter sequencegenetic strategygenomic effortgenomic strategyindividuals with CFindividuals with cystic fibrosisinfected with P. aeruginosainfected with Pseudomonas aeruginosaliving systemmembermicrobe communitymicrobialmicrobial communitymicrobial consortiamicrobial floramicrobiotamicrobiota communitymicrobiota compositionmicrofloramicroorganismmicroorganism communitymixed species biofilmmortalitymucousmulti-microorganism biofilmmultispecies biofilmmultispecies consortiamutantnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetontogenypathogenpathogenic bacteriapathwaypatients with CFpatients with cystic fibrosispersistent infectionpolymicrobial biofilmpolymicrobial communitypromoter sequencequorum sensingrespiratory colonizationrespiratory microbiotarespiratory pathogenrespiratory tract epitheliumsocial roletranscription factorupper airway tract
Description preview
SUMMARY/ABSTRACT
Dense microbial communities known as the microbiota are intimately associated with human health. Invading
pathogens must overcome the microbiota to establish and successfully cause infections. In settings like the
gastrointestinal tract, antagonistic interactions between microbes can strongly influence colonization outcomes.
One…
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