grant
Immunosuppressive Neutrophils Modulate Alloimmune Responses After Lung Transplantation
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 15 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY20252-photonAcuteAffectAllograftingAnimal ModelAnimal Models and Related StudiesAnti-Rejection TherapyBehaviorBeta Proprotein Interleukin 1BioinformaticsBlood NeutrophilBlood Polymorphonuclear NeutrophilBone MarrowBone Marrow Reticuloendothelial SystemC-C CKR-1C-C Chemokine Receptor Type 1CC chemokine receptor 1CC-CKR-1CCL5CCR-1CCR1CCR1 geneCCR1 receptorsCKR-1CMKBR1CMKR1CMKR1 GeneCSF3CSF3 geneCXCL12CXCL12 geneCXCL12 proteinCause of DeathCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell Migration AssayCell SignalingCellsCellular AssayChemokine (C-C Motif) Ligand 5Chemokine (C-C Motif) Receptor 1Chemokine (C-X-C Motif) Ligand 12Chemokine Receptor GeneChemotactic CytokinesChemotaxisChronicClinicalCytotoxic cellD17S136EDataDevelopmentDevelopment PlansDevelopment and ResearchDysfunctionEmergenciesEmergency SituationExtravasationFailureFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFunctional disorderFundingG-CSFGCSFGoalsGrafting ProcedureHM145HistologyHistopathologyHomingHomologous Chemotactic CytokinesHumanIL-1 betaIL-1 βIL-1-bIL-1βIL1-BetaIL1-βIL1B ProteinIL1F2IL1βImageImaging ProceduresImaging TechnicsImaging TechniquesImmuneImmunesImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunosuppressive TherapyIn VitroIncrease lifespanInflammationInflammatoryInjuryInnate Immune ResponseIntercrinesInterleukin 1betaInterleukin-1 betaInterleukin-1βIntracellular Communication and SignalingInvestigationIschemia-Reperfusion InjuryK lymphocyteKidney GraftingKidney TransplantationKidney TransplantsKnowledgeLD78 ReceptorLeakageLigandsLinkLungLung GraftingLung Respiratory SystemLung TransplantationMGC17164MGC45931MIP-1 Alpha-RMIP-1Alpha-RMIP1aRMacrophage Inflammatory Protein-1 Alpha ReceptorMarrow NeutrophilMediatingMediatorMedicalMentorsMiceMice MammalsMigration AssayModelingModern ManMurineMusMyeloid CellsMyelopoiesisNK CellsNatural Killer CellsNatureNeutrophil InfiltrationNeutrophil RecruitmentNeutrophiliaNeutrophilic GranulocyteNeutrophilic InfiltrateNeutrophilic LeukocyteOperative ProceduresOperative Surgical ProceduresOrganOrgan TransplantationOrgan TransplantsOutcomePBSFPathway interactionsPhenotypePhysiciansPhysiopathologyPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPopulationPre-B Cell Growth Stimulating FactorPreinterleukin 1 BetaPreventionProductionPulmonary GraftPulmonary TransplantPulmonary TransplantationR & DR&DR-Series Research ProjectsR01 MechanismR01 ProgramRANTESRANTES Receptor GeneRANTES-RRecombinant G-CSFRecombinant Granulocyte Colony Stimulating FactorRenal GraftingRenal TransplantationRenal TransplantsReperfusion DamageReperfusion InjuryResearchResearch GrantsResearch Project GrantsResearch ProjectsResearch ResourcesResourcesRisk FactorsRoleSCYA5SCYB12SDF-1SDF-1ASDF-1BSDF-1alphaSDF1SDF1ASDF1BSIS cytokinesSIS deltaSIS-deltaSISdScientistSdf1 proteinShapesSignal InductionSignal TransductionSignal Transduction SystemsSignalingSmall Inducible Cytokine A5SolidSpillageStromal Cell-Derived Factor 1SurgicalSurgical InterventionsSurgical ProcedureT cell responseT-Cell RANTES ProteinT-Cell Specific Protein p288TCP228TLSF-ATLSF-BTPAR1TechniquesTestingTherapeutic immunosuppressionTimeTrainingTransplant RecipientsTransplant immunologyTransplantationTransplantation ImmunologyUniversitiesWaiting ListsWashingtonWorkadaptive immunityallograft rejectionartificial immunosuppressionbiological signal transductionboost longevitycareer developmentcell assaycellular differentiationchemoattractant cytokinechemokinechemokine receptorcytokinedevelopmentalelongating the lifespanenhance longevityextend life spanextend lifespanextend longevityflow cytophotometryfoster longevityhIRHhuman modelimagingimmune suppressionimmune suppressive activityimmune suppressive functionimmunosuppression therapyimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprove lifespanimprove longevityimprovedimproved outcomeinjuriesinsightkidney txlifespan extensionlung allograftlung developmentlung transplantmedical collegemedical schoolsmodel of animalmodel of humanmouse modelmurine modelneutrophilnovelorgan allograftorgan graftorgan xenograftpathophysiologypathwaypreventpreventingprogramsprolong lifespanprolong longevitypromote lifespanpromote longevitypulmonaryresearch and developmentresponsescRNA sequencingscRNA-seqschool of medicinesingle cell RNA-seqsingle cell RNAseqsingle cell analysissingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskillssocial rolestromal cell-derived factor-1alphasupport longevitysurgerytooltraffickingtransplanttransplant modeltransplant patienttumortwo-photonwaitlist
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Project Summary/Abstract
This proposal outlines a 5-year research and career development plan to support Dr. Amit Bery’s transition to
independence as a physician-scientist studying how innate immune cells affect adaptive immunity after lung
transplantation. The proposed research project, which focuses on how interleukin-1β (IL-1β) promotes the…
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