grant
Immunology of aging and immunotherapy of aging-associated diseases
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AccelerationAddressAdenosineAffectAge related pathologiesAgingB blood cellsB cellB cellsB-Cell SubsetsB-CellsB-Lymphocyte SubsetsB-LymphocytesB-cellB16F10BONZOBloodBlood Reticuloendothelial SystemBreast CancerCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCXCR6CXCR6 geneCancer InductionCancersCell BodyCellsCheckpoint inhibitorChemotactic CytokinesClinicalDiseaseDisorderEffector CellHomologous Chemotactic CytokinesHumanImmuneImmune checkpoint inhibitorImmune mediated therapyImmune systemImmunesImmunologically Directed TherapyImmunologyImmunomodulationImmunotherapyInsulin ResistanceIntercrinesLinkMacrophageMalignant Breast NeoplasmMalignant MelanomaMalignant NeoplasmsMalignant TumorMediatingMelanomaMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMiceMice MammalsMinorModern ManMurineMusMφNatureNeoplasm MetastasisOlder PopulationOutcomePathogenicityPatientsPrevalencePublicationsReceptor ProteinReportingRoleSIS cytokinesSTRL33ScienceScientific PublicationSecondary NeoplasmSecondary TumorSurfaceT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsT8 CellsT8 LymphocytesTYMSTRTumor PromotionTumor Tissueage associatedage associated diseaseage associated disorderage associated impairmentage associated pathologiesage correlatedage dependentage dependent diseaseage dependent disorderage dependent impairmentage dependent pathologiesage induced pathologiesage linkedage relatedage related human diseaseage specificage-related diseaseage-related disorderage-related impairmentagedaged miceaged mouseaging associatedaging associated diseaseaging associated disordersaging associated pathologiesaging dependent pathologiesaging induced pathologiesaging pathologiesaging relatedaging related diseaseaging related disordersaging related pathologiescancer metastasiscancer progressioncarcinogenesischemoattractant cytokinechemokinedisease associated with agingdisease of agingdisorder of agingdisorders associated with agingdisorders related to agingelderly miceexhaustextracellularimmune check point inhibitorimmune modulationimmune regulationimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryinsulin resistantinsulin tolerancemalignancymalignant breast tumorneoplasm progressionneoplasm/cancerneoplastic progressionnovelold miceolder groupsolder individualsolder personreceptorrecruitsocial roletherapeutic agent developmenttherapeutic developmentthymus derived lymphocytetumortumor cell metastasistumor growthtumor progression
Description preview
The immune system undergoes significant changes with aging, affecting both the function and subsets of B cells and T cells. These changes, in turn, influence the outcomes of aging-related pathologies and diseases. However, the mechanisms by which aging dysregulates these cells and increases prevalence of age-related diseases remain poorly…
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