grant
Immunological and Microbial Mechanisms in Food Allergy
Organization BOSTON CHILDREN'S HOSPITALLocation BOSTON, UNITED STATESPosted 21 Nov 2016Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY20260-11 years old2,3,7,8-Tetrachlorodibenzo-p-dioxin Receptors21+ years oldAH ReceptorsAcuteAdultAdult HumanAffectAllergensAllergic to foodAllergy to foodAnaphylactic ReactionAnaphylactic ShockAnaphylaxisAryl Hydrocarbon ReceptorB cell growth factorB-Cell Differentiation Factor-1B-Cell Growth Factor-1B-Cell Growth Factor-IB-Cell Proliferating FactorB-Cell Stimulating FactorB-Cell Stimulating Factor-1B-Cell Stimulation Factor-1B-Cell Stimulatory Factor-1BCDF-1BCGFBCGF-1BCSF 1BSF-1BSF1BinetrakinBlood SerumCell BodyCell DifferentiationCell Differentiation processCellsChildChild YouthChildren (0-21)Clinical Treatment MoabDedicationsDevelopmentDioxin ReceptorsDiseaseDisorderEnhancer-Binding Protein GATA3Epithelial CellsEpitheliumEvolutionExhibitsFIZZ3FoodFood AllergyFood HypersensitivityFound in Inflammatory Zone 3FrequenciesGATA-3 factorsGATA-3 proteinGATA-Binding Protein 3GATA3GATA3 geneGATA3 proteinGATA3 transcription factorGI commensalGI microbiotaGastrointestinal microbiotaGene TranscriptionGenesGeneticGenetic TranscriptionGoblet CellsGut EpitheliumHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHigh PrevalenceIL-13IL-4IL13IL4 ProteinIgEImmuneImmune ToleranceImmune responseImmune systemImmunesImmunochemical ImmunologicImmunoglobulin EImmunologicImmunologic ToleranceImmunologicalImmunologicallyImmunologicsIndolesInducer CellsInducer T-LymphocytesInnate Immune ResponseInterleukin-13Interleukin-4Interleukin-4 PrecursorLactobacillusLifeLinkLymphocyte Stimulatory Factor 1MCGF-2Marrow Mast CellMast Cell Growth Factor-2MediatingMiceMice MammalsMonoclonal AntibodiesMurineMusNamesNuclear TranslocatorOralParasitic infectionPathogenesisPathogenicityPathologyPatientsPhenotypePlayPolyaromatic Hydrocarbon ReceptorsPopulationPredispositionPreventative strategyPrevention strategyPreventive strategyProductionProteinsPublic HealthRETNRNA ExpressionReactionReceptor ProteinRegulatory T-LymphocyteRiskRoleSerumSeverity of illnessSusceptibilityT-Cell Growth Factor 2TCDD ReceptorsTSLPTSLP geneThymic Stromal LymphopoietinTissue BasophilsTranscriptionTregWeaningadulthoodallergen responseallergic responseallergy responseantagonismantagonistcell typecellular differentiationcommensal bacteria in the gastrointestinal tractcommensal bacteria in the gutcommensal bacteria in the intestinecytokinedevelopmentaldisease severitydysbacteriosisdysbiosisdysbioticeffective therapyeffective treatmententeric commensalenteric microbial communityenteric microbiotafood Ingestionfood allergenfood consumptiongastrointestinal commensalgastrointestinal epitheliumgastrointestinal microbial floragut commensalgut communitygut dysbiosisgut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiotagut microbioticgut microflorahost responsehuman subjectimmune system responseimmune system toleranceimmune unresponsivenessimmunological paralysisimmunoresponseimprovedinfected with parasitesinsightintestinal commensalintestinal floraintestinal microbiotaintestinal microfloraintestinal tract microflorakidsmAbsmast cellmastocytemetabolism measurementmetabolomicsmetabonomicsmicrobialmicrobial consortiamicrobial floramicrobial imbalancemicrobiotamicrofloramonoclonal Absmouse modelmultispecies consortiamurine modelnamenamednamingnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachoral immunotherapyoral toleranceparasite infectionpredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerprogramsreceptorreceptor expressionregulatory T-cellsresistinresponsesegregationsocial roleyoungster
Description preview
ABSTRACT
The high prevalence of food allergy (FA) places many at risk of severe reactions to foods including anaphylaxis
(1). Our studies on human subjects with FA and in relevant mouse models have identified changes in regulatory
T (Treg) cell populations as playing a pivotal role in disease pathogenesis. Specifically, we have identified a…
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